(Q33769093)

29 July 2017

title

ENU mutagenesis identifies mice with morbid obesity and severe hyperinsulinemia caused by a novel mutation in leptin (English)

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29 July 2017

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Shih-Jen Tsai

12

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author name string

Chen-Jee Hong

1

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29 July 2017

Pei-Jane Tsai

2

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29 July 2017

Chih-Ya Cheng

3

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29 July 2017

Chuan-Kai Chou

4

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29 July 2017

Huei-Fen Jheng

5

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29 July 2017

You-Chung Chuang

6

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29 July 2017

Chia-Ning Yang

7

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29 July 2017

Ya-Tzu Lin

8

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29 July 2017

Chih-Wei Hsu

9

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29 July 2017

Irene H Cheng

10

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29 July 2017

Shiow-Yi Chen

11

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29 July 2017

Ying-Jay Liou

13

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29 July 2017

Yau-Sheng Tsai

14

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29 July 2017

language of work or name

English

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publication date

9 December 2010

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29 July 2017

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29 July 2017

volume

5

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29 July 2017

issue

12

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29 July 2017

page(s)

e15333

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Creative Commons Attribution 4.0 International

29 July 2017

copyright license

start time

9 December 2010

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Decreased PPAR gamma expression compromises perigonadal-specific fat deposition and insulin sensitivity

14 July 2018

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A new mouse model of metabolic syndrome and associated complications

14 July 2018

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Adipocytes as regulators of energy balance and glucose homeostasis

14 July 2018

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Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies

14 July 2018

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Leptin: structure, function and biology

14 July 2018

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Identification of the hydrophobic strand in the A-B loop of leptin as major binding site III: implications for large-scale preparation of potent recombinant human and ovine leptin antagonists.

14 July 2018

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Mapping of the leptin binding sites and design of a leptin antagonist

14 July 2018

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Adiponectin and its role in the obesity-induced insulin resistance and related complications.

14 July 2018

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Functional Analysis of Leptin Receptor Activation Using a Janus Kinase/Signal Transducer and Activator of Transcription Complementation Assay

14 July 2018

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A simple method for the isolation and purification of total lipides from animal tissues

14 July 2018

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Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex

14 July 2018

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The ins and outs of leptin receptor activation

14 July 2018

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The use of MassARRAY technology for high throughput genotyping

14 July 2018

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Subcloning, expression, purification, and characterization of recombinant human leptin-binding domain

14 July 2018

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Structure of an extracellular gp130 cytokine receptor signaling complex

14 July 2018

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Receptor recognition by gp130 cytokines

14 July 2018

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Leptin and the regulation of body weight in mammals

14 July 2018

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Genetic markers at the leptin (OB) locus are not significantly linked to hypertension in African Americans

14 July 2018

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Localization of leptin binding domain in the leptin receptor.

14 July 2018

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Congenital leptin deficiency is associated with severe early-onset obesity in humans

14 July 2018

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The molecular basis of the obese mutation in ob2J mice

14 July 2018

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Crystal structure of the obese protein leptin-E100

14 July 2018

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Mapping the protein universe

14 July 2018

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Positional cloning of the mouse obese gene and its human homologue

14 July 2018

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A leptin missense mutation associated with hypogonadism and morbid obesity.

14 July 2018

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Partial leptin deficiency and human adiposity.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015333

A novel homozygous missense mutation of the leptin gene (N103K) in an obese Egyptian patient.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015333

A human leptin mutant induces weight gain in normal mice

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015333

The obese phenotype-inducing N82K mutation in human leptin disrupts receptor-binding and biological activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015333

No evidence for involvement of the leptin gene in anorexia nervosa, bulimia nervosa, underweight or early onset extreme obesity: identification of two novel mutations in the coding sequence and a novel polymorphism in the leptin gene linked upstream

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015333

A simple method to determine fat cell size and number in four mammalian species

21 January 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000341

Identification of two novel missense mutations in the human OB gene

30 October 2018

1 reference

12 December 2020

The involvement of leptin in humans revealed by mutations in leptin and leptin receptor genes

1 reference

12 December 2020

A peptide leptin antagonist reduces food intake in rodents

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12 December 2020

Adipokine and insulin profiles distinguish diabetogenic and non-diabetogenic obesities in mice

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12 December 2020

Optimal N-ethyl-N-nitrosourea (ENU) doses for inbred mouse strains

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0015333

Identifiers

DOI

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29 July 2017

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29 July 2017

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