(Q33801629)

English

IL-4 signaling drives a unique arginase+/IL-1β+ microglia phenotype and recruits macrophages to the inflammatory CNS: consequences of age-related deficits in IL-4Rα after traumatic spinal cord injury

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scholarly article

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Europe PubMed Central

PubMed publication ID

29 July 2017

IL-4 signaling drives a unique arginase+/IL-1β+ microglia phenotype and recruits macrophages to the inflammatory CNS: consequences of age-related deficits in IL-4Rα after traumatic spinal cord injury (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

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author name string

Ashley M Fenn

1

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Jodie C E Hall

2

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

John C Gensel

3

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Phillip G Popovich

4

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Jonathan P Godbout

5

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Europe PubMed Central

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29 July 2017

language of work or name

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publication date

1 June 2014

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Europe PubMed Central

PubMed publication ID

29 July 2017

Journal of Neuroscience

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Europe PubMed Central

PubMed publication ID

29 July 2017

34

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Europe PubMed Central

PubMed publication ID

29 July 2017

26

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

8904-8917

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4069360/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

TGFβ produced by IL-10 redirected astrocytes attenuates microglial activation

1 reference

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Toll-like receptor 2-mediated alternative activation of microglia is protective after spinal cord injury.

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4 July 2018

Immune activation promotes depression 1 month after diffuse brain injury: a role for primed microglia

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4 July 2018

GM-CSF promotes the immunosuppressive activity of glioma-infiltrating myeloid cells through interleukin-4 receptor-α.

1 reference

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4 July 2018

Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior

1 reference

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4 July 2018

Aging enhances classical activation but mitigates alternative activation in the central nervous system

1 reference

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4 July 2018

Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states

1 reference

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4 July 2018

Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice.

1 reference

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Blockade of interleukin-6 signaling inhibits the classic pathway and promotes an alternative pathway of macrophage activation after spinal cord injury in mice

1 reference

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4 July 2018

Lipopolysaccharide-induced interleukin (IL)-4 receptor-α expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice

1 reference

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Deficient CX3CR1 signaling promotes recovery after mouse spinal cord injury by limiting the recruitment and activation of Ly6Clo/iNOS+ macrophages

1 reference

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4 July 2018

Repertoire of microglial and macrophage responses after spinal cord injury

1 reference

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4 July 2018

β-Adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat

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4 July 2018

LPS-induced CCL2 expression and macrophage influx into the murine central nervous system is polyamine-dependent

1 reference

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4 July 2018

Endogenous expression of interleukin-4 regulates macrophage activation and confines cavity formation after traumatic spinal cord injury

1 reference

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4 July 2018

Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord

1 reference

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4 July 2018

Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice

1 reference

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4 July 2018

Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis

1 reference

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4 July 2018

Macrophages promote axon regeneration with concurrent neurotoxicity

1 reference

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4 July 2018

Exploring the full spectrum of macrophage activation

1 reference

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4 July 2018

Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1beta and anti-inflammatory IL-10 cytokines

1 reference

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4 July 2018

Exacerbated glial response in the aged mouse hippocampus following controlled cortical impact injury

1 reference

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4 July 2018

Voluntary running attenuates age-related deficits following SCI.

1 reference

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4 July 2018

Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice

1 reference

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Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide

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4 July 2018

IL-4 attenuates the neuroinflammation induced by amyloid-beta in vivo and in vitro

1 reference

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4 July 2018

Microglia derived from aging mice exhibit an altered inflammatory profile.

1 reference

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4 July 2018

Comparative analysis of lesion development and intraspinal inflammation in four strains of mice following spinal contusion injury

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4 July 2018

Functional recovery in traumatic spinal cord injury after transplantation of multineurotrophin-expressing glial-restricted precursor cells

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4 July 2018

Contribution of macrophages to enhanced regenerative capacity of dorsal root ganglia sensory neurons by conditioning injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4069360

30 October 2018

Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4069360

30 October 2018

Ly6C+ Ly6G- Myeloid-derived suppressor cells play a critical role in the resolution of acute inflammation and the subsequent tissue repair process after spinal cord injury.

1 reference

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30 October 2018

Transcriptional profiling of the injured sciatic nerve of mice carrying the Wld(S) mutant gene: identification of genes involved in neuroprotection, neuroinflammation, and nerve regeneration

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IL4 gene delivery to the CNS recruits regulatory T cells and induces clinical recovery in mouse models of multiple sclerosis.

1 reference

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30 October 2018

Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains.

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30 October 2018

Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells.

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IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing mice

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30 October 2018

A nationwide epidemiological study of spinal cord injury in geriatric patients in Taiwan.

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Protective effects of an anti-inflammatory cytokine, interleukin-4, on motoneuron toxicity induced by activated microglia

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Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/24966389

12 December 2020

based on heuristic

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Mortality rates in geriatric patients with spinal cord injuries

1 reference

https://pubmed.ncbi.nlm.nih.gov/24966389

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detrimental effects of aging on outcome from traumatic brain injury: a behavioral, magnetic resonance imaging, and histological study in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24966389

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based on heuristic

inferred from PubMed ID database lookup

Traumatic spinal cord injury produced by controlled contusion in mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/24966389

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based on heuristic

inferred from PubMed ID database lookup

Interleukin-4-inhibited mRNA expression in mixed rat glial and in isolated microglial cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/24966389

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based on heuristic

inferred from PubMed ID database lookup

Rats and mice exhibit distinct inflammatory reactions after spinal cord injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/24966389

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Locomotor recovery and mechanical hyperalgesia following spinal cord injury depend on age at time of injury in rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/24966389

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based on heuristic

inferred from PubMed ID database lookup

Cellular inflammatory response after spinal cord injury in Sprague-Dawley and Lewis rats

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.1146-14.2014

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

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