(Q33825111)

29 July 2017

title

p35 is required for CDK5 activation in cellular senescence (English)

1 reference

29 July 2017

1 reference

Daqin Mao

1

1 reference

29 July 2017

Philip W Hinds

series ordinal

2

1 reference

29 July 2017

language of work or name

English

0 references

publication date

24 February 2010

1 reference

Journal of Biological Chemistry

29 July 2017

published in

1 reference

29 July 2017

volume

285

1 reference

29 July 2017

issue

19

1 reference

29 July 2017

page(s)

14671-14680

1 reference

describes a project that uses

29 July 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2863219/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

Cellular senescence: when bad things happen to good cells

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

Extraneuronal roles of cyclin-dependent kinase 5.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

Oncogene-Induced Senescence: Putting the Brakes on Tumor Development

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

Phosphorylation of ezrin by cyclin-dependent kinase 5 induces the release of Rho GDP dissociation inhibitor to inhibit Rac1 activity in senescent cells

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

BRAFE600-associated senescence-like cell cycle arrest of human naevi

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

Tumour biology: senescence in premalignant tumours

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

p19Arf suppresses growth, progression, and metastasis of Hras-driven carcinomas through p53-dependent and -independent pathways

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

Up-regulation of Egr1 by 1,25-dihydroxyvitamin D3 contributes to increased expression of p35 activator of cyclin-dependent kinase 5 and consequent onset of the terminal phase of HL60 cell differentiation

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

L6 myoblast differentiation is modulated by Cdk5 via the PI3K-AKT-p70S6K signaling pathway

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

Cellular senescence requires CDK5 repression of Rac1 activity

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

Reversal of human cellular senescence: roles of the p53 and p16 pathways

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

Oncogenic ras and p53 cooperate to induce cellular senescence

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

Cell senescence and cancer

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

Cellular senescence as a tumor-suppressor mechanism

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

Requirement for p27(KIP1) in retinoblastoma protein-mediated senescence

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblasts

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

Cyclin dependent kinase 5, cdk5, is a positive regulator of myogenesis in mouse C2 cells

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

G1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

Microarray analysis of replicative senescence

4 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.066118

Oncogene-induced senescence as an initial barrier in lymphoma development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.066118

Increased ezrin expression and activation by CDK5 coincident with acquisition of the senescent phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.066118

Region-specific expression of cyclin-dependent kinase 5 (cdk5) and its activators, p35 and p39, in the developing and adult rat central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.066118

p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.066118

The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.066118

DNA damage is able to induce senescence in tumor cells in vitro and in vivo.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863219

Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a Senescence-like Arrest Mediated by p27Kip1

29 October 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.066118

A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

21 January 2018

1 reference

12 December 2020

A role for both RB and p53 in the regulation of human cellular senescence

1 reference

12 December 2020

p16 INK4a can initiate an autonomous senescence program

1 reference

12 December 2020

Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition

1 reference

12 December 2020

A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M109.066118

1 reference

29 July 2017

1 reference

29 July 2017

1 reference