(Q33831775)

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Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5).

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Europe PubMed Central

29 July 2017

Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5). (English)

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Europe PubMed Central

29 July 2017

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object named as

Andres M Lozano

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Europe PubMed Central

29 July 2017

5

object named as

Bradley T Hyman

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Europe PubMed Central

29 July 2017

author name string

Lorraine V Kalia

1

1 reference

Europe PubMed Central

29 July 2017

Suneil K Kalia

2

1 reference

Europe PubMed Central

29 July 2017

Hien Chau

3

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Europe PubMed Central

29 July 2017

Pamela J McLean

6

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Europe PubMed Central

29 July 2017

language of work or name

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publication date

16 February 2011

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Europe PubMed Central

29 July 2017

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Europe PubMed Central

29 July 2017

6

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Europe PubMed Central

29 July 2017

2

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Europe PubMed Central

29 July 2017

e14695

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Europe PubMed Central

29 July 2017

copyright license

Creative Commons Attribution 4.0 International

16 February 2011

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April 2022 Public Data File from Crossref

copyright status

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Molecular chaperones as rational drug targets for Parkinson's disease therapeutics

1 reference

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The C-terminal BAG domain of BAG5 induces conformational changes of the Hsp70 nucleotide-binding domain for ADP-ATP exchange

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Regulation of translesion synthesis DNA polymerase eta by monoubiquitination

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Yeast unfolds the road map toward alpha-synuclein-induced cell death

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Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

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Genome-wide association study reveals genetic risk underlying Parkinson's disease

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Regulation of LRRK2 stability by the E3 ubiquitin ligase CHIP

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Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

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The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule.

1 reference

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CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

1 reference

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Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2

1 reference

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Structural insights on physiological functions and pathological effects of alpha-synuclein.

1 reference

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CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins

1 reference

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CHIP targets toxic alpha-Synuclein oligomers for degradation

1 reference

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Formation of toxic oligomeric alpha-synuclein species in living cells

1 reference

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Regulation of Pax3 by proteasomal degradation of monoubiquitinated protein in skeletal muscle progenitors

1 reference

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CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3040167

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BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3040167

4 July 2018

Regulation of the cytoplasmic quality control protein degradation pathway by BAG2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3040167

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The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3040167

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Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

1 reference

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BAG5 inhibits parkin and enhances dopaminergic neuron degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3040167

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Ubiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3040167

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CHIP: a link between the chaperone and proteasome systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3040167

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Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3040167

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N-terminal ubiquitination: more protein substrates join in.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3040167

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Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity

1 reference

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Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.

1 reference

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Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease

1 reference

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1 reference

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ErbB2 degradation mediated by the co-chaperone protein CHIP

1 reference

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CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

1 reference

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1 reference

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1 reference

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Identification of ubiquitin ligases required for skeletal muscle atrophy

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1 reference

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CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3040167

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Protein regulation by monoubiquitin

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions

1 reference

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Alpha-synuclein in Lewy bodies

1 reference

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1 reference

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CHIP overexpression reduces mutant androgen receptor protein and ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0014695

21 January 2018

Ubiquitylation of BAG-1 suggests a novel regulatory mechanism during the sorting of chaperone substrates to the proteasome

1 reference

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Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0014695

21 January 2018

Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0014695

21 January 2018

Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0014695

21 January 2018

Ubiquitination of alpha-synuclein by Siah-1 promotes alpha-synuclein aggregation and apoptotic cell death.

1 reference

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1 reference

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29 October 2018

A highly sensitive protein-protein interaction assay based on Gaussia luciferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/21358815

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1371/JOURNAL.PONE.0014695

1 reference

Europe PubMed Central

29 July 2017

2011PLoSO...614695K

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1 reference

Europe PubMed Central

29 July 2017

1 reference

Europe PubMed Central

29 July 2017

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