(Q37658298)

21 August 2017

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title

Yeast unfolds the road map toward alpha-synuclein-induced cell death (English)

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21 August 2017

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V Franssens

1

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21 August 2017

E Boelen

2

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21 August 2017

J Anandhakumar

3

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21 August 2017

T Vanhelmont

4

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21 August 2017

S Büttner

5

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21 August 2017

J Winderickx

6

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21 August 2017

publication date

18 December 2009

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Cell Death & Differentiation

21 August 2017

published in

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21 August 2017

volume

17

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21 August 2017

issue

5

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21 August 2017

page(s)

746-753

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https://scigraph.springernature.com/pub.10.1038/cdd.2009.203

21 August 2017

exact match

0 references

cites work

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Role of molecular chaperones in neurodegenerative disorders

21 January 2018

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Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome

21 January 2018

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The role of antioxidants and antioxidant-related enzymes in protective responses to environmentally induced oxidative stress

21 January 2018

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Proteasomal dysfunction: a common feature of neurodegenerative diseases? Implications for the environmental origins of neurodegeneration

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2009.203

Oxidative stress and neurodegeneration: where are we now?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Endoplasmic reticulum stress response and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Regulation of autophagy in yeast Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Complex cellular responses to reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

An HRD/DER-independent ER quality control mechanism involves Rsp5p-dependent ubiquitination and ER-Golgi transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Protein quality control in neurodegeneration: walking the tight rope between health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Free radicals in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Proteasome synthesis and assembly are required for survival during stationary phase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Physiological and pathological properties of alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Molecular basis of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Chaperone-like activity of synucleins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

The role of alpha-synuclein in brain lipid metabolism: a downstream impact on brain inflammatory response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease alpha-synuclein fibrillogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Genetics of Parkinson's disease and parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Lewy-body formation is an aggresome-related process: a hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

alpha-synuclein promotes mitochondrial deficit and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Localization of alpha-synuclein to mitochondria within midbrain of mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Proteasomal inhibition by alpha-synuclein filaments and oligomers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Cell death pathways in Parkinson's disease: role of mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Alpha-synuclein targets the plasma membrane via the secretory pathway and induces toxicity in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Characterization of alpha-synuclein aggregation and synergistic toxicity with protein tau in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Alpha-synuclein-induced aggregation of cytoplasmic vesicles in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Lipid rafts mediate the synaptic localization of alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Phosphorylation, lipid raft interaction and traffic of alpha-synuclein in a yeast model for Parkinson

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Relationships between the sequence of alpha-synuclein and its membrane affinity, fibrillization propensity, and yeast toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

The first N-terminal amino acids of alpha-synuclein are essential for alpha-helical structure formation in vitro and membrane binding in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Impairment of microtubule system increases alpha-synuclein aggregation and toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Yeast cells provide insight into alpha-synuclein biology and pathobiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

alpha-Synuclein budding yeast model: toxicity enhanced by impaired proteasome and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

alpha-Synuclein fission yeast model: concentration-dependent aggregation without plasma membrane localization or toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Alpha-synuclein aggregation and Ser-129 phosphorylation-dependent cell death in oligodendroglial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Replication stress, defective S-phase checkpoint and increased death in Plk2-deficient human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Novel suppressors of alpha-synuclein toxicity identified using yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Mechanisms of Suppression of {alpha}-Synuclein Neurotoxicity by Geldanamycin in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Geldanamycin induces heat shock protein 70 and protects against MPTP-induced dopaminergic neurotoxicity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Glycogen synthase phosphatase interacts with heat shock factor to activate CUP1 gene transcription in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Alpha-synuclein alters proteasome function, protein synthesis, and stationary phase viability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

YGR198w (YPP1) targets A30P alpha-synuclein to the vacuole for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

A yeast-based model of alpha-synucleinopathy identifies compounds with therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Human alpha-synuclein over-expression increases intracellular reactive oxygen species levels and susceptibility to dopamine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Accumulation of misfolded protein through nitrosative stress linked to neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Caspase-dependent and caspase-independent cell death pathways in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

A non-death role of the yeast metacaspase: Yca1p alters cell cycle dynamics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Functional mitochondria are required for alpha-synuclein toxicity in aging yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

Evidence that alpha-synuclein does not inhibit phospholipase D

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

The chronological life span of Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

7 January 2021

Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

7 January 2021

Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

7 January 2021

Heat shock proteins reduce alpha-synuclein aggregation induced by MPP+ in SK-N-SH cells

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.203

7 January 2021

Identifiers

DOI

10.1038/CDD.2009.203

1 reference

21 August 2017

1 reference