(Q33835308)

29 July 2017

title

Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillation (English)

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29 July 2017

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9

Xander H T Wehrens

1 reference

29 July 2017

Jun Wang

1

1 reference

29 July 2017

Yan Bai

2

1 reference

29 July 2017

Na Li

3

1 reference

29 July 2017

Wenduo Ye

4

1 reference

29 July 2017

Min Zhang

5

1 reference

29 July 2017

Stephanie B Greene

6

1 reference

29 July 2017

Ye Tao

7

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29 July 2017

Yiping Chen

8

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29 July 2017

James F Martin

10

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29 July 2017

language of work or name

English

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publication date

10 June 2014

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Proceedings of the National Academy of Sciences of the United States of America

29 July 2017

published in

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29 July 2017

volume

111

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29 July 2017

issue

25

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29 July 2017

page(s)

9181-9186

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Inhibition of miR-25 improves cardiac contractility in the failing heart.

29 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

Atrial Fibrillation associated chromosome 4q25 variants are not associated with PITX2c expression in human adult left atrial appendages

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

Pitx2, an atrial fibrillation predisposition gene, directly regulates ion transport and intercalated disc genes

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

MicroRNA-17-92, a direct Ap-2α transcriptional target, modulates T-box factor activity in orofacial clefting

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

mir-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

MicroRNA-26 governs profibrillatory inward-rectifier potassium current changes in atrial fibrillation

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

MicroRNA29: a mechanistic contributor and potential biomarker in atrial fibrillation

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

Cardiovascular dysregulation of miR-17-92 causes a lethal hypertrophic cardiomyopathy and arrhythmogenesis

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

The expression levels of plasma micoRNAs in atrial fibrillation patients

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

Transient receptor potential canonical-3 channel-dependent fibroblast regulation in atrial fibrillation

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

Role for MicroRNA-21 in atrial profibrillatory fibrotic remodeling associated with experimental postinfarction heart failure.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

Role of miR-21 in the pathogenesis of atrial fibrosis

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

Epistatic rescue of Nkx2.5 adult cardiac conduction disease phenotypes by prospero-related homeobox protein 1 and HDAC3.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

The microRNA-17-92 family of microRNA clusters in development and disease

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

Role of RyR2 phosphorylation at S2814 during heart failure progression

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial fibrillation in FKBP12.6 knockout mice

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

Large-scale discovery of enhancers from human heart tissue

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

Electrophysiological mapping of embryonic mouse hearts: mechanisms for developmental pacemaker switch and internodal conduction pathway

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

Therapeutic inhibition of miR-208a improves cardiac function and survival during heart failure

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

MicroRNA-328 contributes to adverse electrical remodeling in atrial fibrillation

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

Shox2 mediates Tbx5 activity by regulating Bmp4 in the pacemaker region of the developing heart

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

Genome-wide association study of PR interval

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

Long-term outcomes in individuals with prolonged PR interval or first-degree atrioventricular block

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

MicroRNAs: target recognition and regulatory functions

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

miRiad roles for the miR-17-92 cluster in development and disease

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

Variants conferring risk of atrial fibrillation on chromosome 4q25.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

New insights into pacemaker activity: promoting understanding of sick sinus syndrome

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

Targeted mutation reveals essential functions of the homeodomain transcription factor Shox2 in sinoatrial and pacemaking development

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

Developmental and adult phenotyping directly from mutant embryonic stem cells

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

Pitx2c patterns anterior myocardium and aortic arch vessels and is required for local cell movement into atrioventricular cushions

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078868

Conduction patterns in the cardiac veins: electrophysiologic characteristics of the connections between left atrial and coronary sinus musculature

4 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405411111

Catheter ablation of paroxysmal atrial fibrillation initiated by non-pulmonary vein ectopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405411111

Chromosome 4q25 variants and atrial fibrillation recurrence after catheter ablation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405411111

Prediction of sinus node dysfunction in patients with long-standing persistent atrial fibrillation using the atrial fibrillatory cycle length.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405411111

Early mesodermal cues assign avian cardiac pacemaker fate potential in a tertiary heart field

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405411111

The role of Shox2 in SAN development and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405411111

T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405411111

MicroRNA expression signature in atrial fibrillation with mitral stenosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405411111

PITX2c Is Expressed in the Adult Left Atrium, and Reducing Pitx2c Expression Promotes Atrial Fibrillation Inducibility and Complex Changes in Gene Expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1405411111

21 January 2018

Identifiers

DOI

10.1073/PNAS.1405411111

1 reference

29 July 2017

0 references

1 reference

29 July 2017

1 reference