(Q33849248)

29 July 2017

title

Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy (English)

1 reference

29 July 2017

10

Kwok-Kin Wong

1 reference

29 July 2017

7

Nabeel Bardeesy

0 references

author name string

Cristina M Contreras

1

1 reference

29 July 2017

Esra A Akbay

2

1 reference

29 July 2017

Teresa D Gallardo

3

1 reference

29 July 2017

J Marshall Haynie

4

1 reference

29 July 2017

Sreenath Sharma

5

1 reference

29 July 2017

Osamu Tagao

6

1 reference

29 July 2017

Nabeel Bardeesy

7

1 reference

29 July 2017

Masaya Takahashi

8

1 reference

29 July 2017

Jeff Settleman

9

1 reference

29 July 2017

Diego H Castrillon

11

1 reference

29 July 2017

publication date

8 February 2010

1 reference

Disease Models & Mechanisms

29 July 2017

published in

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29 July 2017

volume

3

1 reference

29 July 2017

issue

3-4

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29 July 2017

page(s)

181-193

1 reference

describes a project that uses

29 July 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2869492/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome

5 July 2018

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Somatic LKB1 mutations promote cervical cancer progression

5 July 2018

1 reference

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Targeting the mTOR signaling network for cancer therapy

5 July 2018

1 reference

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5 July 2018

1 reference

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5 July 2018

1 reference

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beta-catenin mediates glandular formation and dysregulation of beta-catenin induces hyperplasia formation in the murine uterus.

5 July 2018

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5 July 2018

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5 July 2018

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Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma

5 July 2018

1 reference

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5 July 2018

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5 July 2018

1 reference

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Lkb1 deficiency causes prostate neoplasia in the mouse

5 July 2018

1 reference

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5 July 2018

1 reference

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Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms

5 July 2018

1 reference

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5 July 2018

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LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis

5 July 2018

1 reference

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Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling

5 July 2018

1 reference

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Maximizing mouse cancer models

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2869492

LKB1 modulates lung cancer differentiation and metastasis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2869492

Genomewide discovery and classification of candidate ovarian fertility genes in the mouse

5 July 2018

1 reference

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5 July 2018

Endometrial stem cells

1 reference

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Generation of a germ cell-specific mouse transgenic Cre line, Vasa-Cre

5 July 2018

1 reference

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5 July 2018

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1 reference

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LKB1-dependent signaling pathways

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2869492

Crystallization of hepatocyte nuclear factor 1beta in complex with DNA.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2869492

High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2869492

Estrogen regulates the expression of the small proline-rich 2 gene family in the mouse uterus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2869492

Focus on endometrial and cervical cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2869492

Dragon ERE Finder version 2: A tool for accurate detection and analysis of estrogen response elements in vertebrate genomes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2869492

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2869492

Generalized lacZ expression with the ROSA26 Cre reporter strain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2869492

Mouse Sprr2 genes: a clustered family of genes showing differential expression in epithelial tissues

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2869492

Somatic alterations of the serine/threonine kinase LKB1 gene in squamous cell (SCC) and large cell (LCC) lung carcinoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2869492

Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2869492

Reduced progression of endometrial hyperplasia with oral mTOR inhibition in the Pten heterozygote murine model.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2869492

Ten-year results of a prospective study on the prognostic role of ploidy in endometrial carcinoma: dNA aneuploidy identifies high-risk cases among the so-called 'low-risk' patients with well and moderately differentiated tumors

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2869492

Gene expression pattern and hormonal regulation of small proline-rich protein 2 family members in the female mouse reproductive system during the estrous cycle and pregnancy.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2869492

Mouse Sprr locus: a tandem array of coordinately regulated genes

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2869492

Global gene profiling analysis of mouse uterus during the oestrous cycle

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20142330

12 December 2020

inferred from PubMed ID database lookup

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20142330

12 December 2020

inferred from PubMed ID database lookup

Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20142330

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1242/DMM.004440

1 reference

29 July 2017

1 reference

29 July 2017

1 reference