(Q34661270)

3 August 2017

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title

Maximizing mouse cancer models (English)

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3 August 2017

2

David A Tuveson

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3 August 2017

Kristopher K Frese

1

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PubMed ID

17687385

3 August 2017

language of work or name

English

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publication date

1 September 2007

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3 August 2017

Nature Reviews Cancer

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3 August 2017

7

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3 August 2017

645-658

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3 August 2017

9

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https://scigraph.springernature.com/pub.10.1038/nrc2192

3 August 2017

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cites work

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Chromosome abnormalities in malignant hematologic disorders

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Genetic progression in the pancreatic ducts

21 January 2018

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Efficient sequential gene regulation via FLP-and Cre-recombinase using adenovirus vector in mammalian cells including mouse ES cells

21 January 2018

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Functional replacement of the mouse E2A gene with a human HEB cDNA.

21 January 2018

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Cytochrome P450 humanised mice

21 January 2018

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A 320-kilobase artificial chromosome encoding the human HLA DR3-DQ2 MHC haplotype confers HLA restriction in transgenic mice

21 January 2018

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21 January 2018

The Hallmarks of Cancer

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The nonobese diabetic/severe combined immunodeficient (NOD/SCID) mouse model of childhood acute lymphoblastic leukemia reveals intrinsic differences in biologic characteristics at diagnosis and relapse

31 March 2020

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An in vivo platform for translational drug development in pancreatic cancer

31 March 2020

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Disruption of Id1 reveals major differences in angiogenesis between transplanted and autochthonous tumors.

31 March 2020

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Genetically engineered models have advantages over xenografts for preclinical studies

31 March 2020

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Clonal growth of colorectal-carcinoma cell lines transplanted to nude mice

31 March 2020

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The use of molecular genetic markers to demonstrate the effect of organ environment on clonal dominance in a human renal-cell carcinoma grown in nude mice

31 March 2020

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A multigenic program mediating breast cancer metastasis to bone

31 March 2020

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Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials

31 March 2020

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In vitro and in vivo evaluation of US-NCI compounds in human tumor xenografts

31 March 2020

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Factors influencing laboratory animal spontaneous tumor profiles

31 March 2020

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Frequent p53 alterations but low incidence of ras mutations in UV-B-induced skin tumors of hairless mice

31 March 2020

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Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene

31 March 2020

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Mouse mammary tumor biology: a short history

31 March 2020

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Conditional mouse models of sporadic cancer

31 March 2020

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Technologically advanced cancer modeling in mice

31 March 2020

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Regulatory regions driving developmental and tissue-specific expression of the essential pancreatic gene pdx1.

31 March 2020

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31 March 2020

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Position-dependent variegation of globin transgene expression in mice

31 March 2020

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Stringent doxycycline dependent control of CRE recombinase in vivo

31 March 2020

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Inducible gene targeting in mice

31 March 2020

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Cancer. Addiction to oncogenes--the Achilles heal of cancer

31 March 2020

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Essential role for oncogenic Ras in tumour maintenance

31 March 2020

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Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes

31 March 2020

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Reversible tumorigenesis by MYC in hematopoietic lineages

31 March 2020

1 reference

Reversibility of acute B-cell leukaemia induced by BCR-ABL1.

31 March 2020

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Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis

31 March 2020

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Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis.

31 March 2020

1 reference

Developmental stage determines the effects of MYC in the mammary epithelium

31 March 2020

1 reference

Sensitivity to myc-induced apoptosis is retained in spontaneous and transplanted lymphomas of CD2-mycER mice

31 March 2020

1 reference

Modeling the therapeutic efficacy of p53 restoration in tumors

31 March 2020

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Restoration of p53 function leads to tumour regression in vivo

31 March 2020

1 reference

A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice

31 March 2020

1 reference

Induction of ovarian cancer by defined multiple genetic changes in a mouse model system

31 March 2020

1 reference

The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer

31 March 2020

1 reference

The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma

31 March 2020

1 reference

Development of an avian leukosis-sarcoma virus subgroup A pseudotyped lentiviral vector

31 March 2020

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MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer.

31 March 2020

1 reference

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

31 March 2020

1 reference

Mouse models of tumor development in neurofibromatosis type 1

31 March 2020

1 reference

Requirement for a functional Rb-1 gene in murine development

31 March 2020

1 reference

Effects of an Rb mutation in the mouse

31 March 2020

1 reference

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

31 March 2020

1 reference

Targeted oncogene activation by site-specific recombination in transgenic mice

31 March 2020

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A knock-in mouse model of gastrointestinal stromal tumor harboring kit K641E.

31 March 2020

1 reference

Invasive melanoma in Cdk4-targeted mice

31 March 2020

1 reference

Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

31 March 2020

1 reference

Germline KRAS mutations cause Noonan syndrome

31 March 2020

1 reference

Analysis of C-MYC function in normal cells via conditional gene-targeted mutation

31 March 2020

1 reference

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

31 March 2020

1 reference

Cre-mediated chromosome loss in mice.

31 March 2020

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The impact of translocations and gene fusions on cancer causation

31 March 2020

1 reference

Cre-loxP chromosome engineering of a targeted deletion in the mouse corresponding to the 3p21.3 region of homozygous loss in human tumours

31 March 2020

1 reference

Targeted inversion of a polar silencer within the HoxD complex re-allocates domains of enhancer sharing.

31 March 2020

1 reference

A genetic screen identifies novel non-compatible loxP sites.

31 March 2020

1 reference

Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer

31 March 2020

1 reference

Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

31 March 2020

1 reference

Precancerous lesions upon sporadic activation of beta-catenin in mice.

31 March 2020

1 reference

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

31 March 2020

1 reference

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

31 March 2020

1 reference

Reversible gene knockdown in mice using a tight, inducible shRNA expression system

31 March 2020

1 reference

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

31 March 2020

1 reference

Impaired microRNA processing enhances cellular transformation and tumorigenesis

31 March 2020

1 reference

Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse

31 March 2020

1 reference

Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system.

31 March 2020

1 reference

Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult Mice

31 March 2020

1 reference

Phase II and pharmacodynamic study of the farnesyltransferase inhibitor R115777 as initial therapy in patients with metastatic pancreatic adenocarcinoma

31 March 2020

1 reference

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

31 March 2020

1 reference

Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor

31 March 2020

1 reference

Akt-regulated pathways in prostate cancer

31 March 2020

1 reference

Essential role for nuclear PTEN in maintaining chromosomal integrity

31 March 2020

1 reference

Wildtype Kras2 can inhibit lung carcinogenesis in mice

31 March 2020

1 reference

Evaluation of Approaches to Generation of Tissue-specific Knock-in Mice

31 March 2020

1 reference

The invertor knock-in conditional chromosomal translocation mimic

31 March 2020

1 reference

A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors

31 March 2020

1 reference

Unidirectional Cre-mediated genetic inversion in mice using the mutant loxP pair lox66/lox71.

31 March 2020

1 reference

Cre recombinase-mediated inversion using lox66 and lox71: method to introduce conditional point mutations into the CREB-binding protein

31 March 2020

1 reference

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

31 March 2020

1 reference

p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM.

31 March 2020

1 reference

Efficient delivery of Cre-recombinase to neurons in vivo and stable transduction of neurons using adeno-associated and lentiviral vectors

31 March 2020

1 reference

A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent

31 March 2020

1 reference

Elimination of background recombination: somatic induction of Cre by combined transcriptional regulation and hormone binding affinity.

31 March 2020

1 reference

Opinion: the origin of the cancer stem cell: current controversies and new insights

31 March 2020

1 reference

Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression

31 March 2020

1 reference

Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas

31 March 2020

1 reference

Opinion: Comparative biology of mouse versus human cells: modelling human cancer in mice

31 March 2020

1 reference

Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors

31 March 2020

1 reference

A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor.

31 March 2020

1 reference

Recombinase-mediated cassette exchange to rapidly and efficiently generate mice with human cardiac sodium channels.

31 March 2020

1 reference

Manipulating the mouse genome to engineer precise functional syntenic replacements with human sequence.

31 March 2020

1 reference

Hypervariable ultra-long telomeres in mice

31 March 2020

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Telomeres shorten during ageing of human fibroblasts

31 March 2020

1 reference

Developmental and tissue-specific regulation of mouse telomerase and telomere length

31 March 2020

1 reference

Essential role of mouse telomerase in highly proliferative organs

31 March 2020

1 reference

Regulation of murine telomere length by Rtel: an essential gene encoding a helicase-like protein

31 March 2020

1 reference

Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction

31 March 2020

1 reference

Study of P450 function using gene knockout and transgenic mice

31 March 2020

1 reference

Pharmaceutical use of mouse models humanized for the xenobiotic receptor

31 March 2020

1 reference

The CYP2D6 humanized mouse: effect of the human CYP2D6 transgene and HNF4alpha on the disposition of debrisoquine in the mouse.

31 March 2020

1 reference

Expression of the Human CYP3A4 Gene in the Small Intestine of Transgenic Mice: In Vitro Metabolism and Pharmacokinetics of Midazolam

31 March 2020

1 reference

Cytochrome P450 and xenobiotic receptor humanized mice

31 March 2020

1 reference

Cancer immunosurveillance, immunoediting and inflammation: independent or interdependent processes?

31 March 2020

1 reference

Paradoxical roles of the immune system during cancer development

31 March 2020

1 reference

Humanized mice in translational biomedical research

31 March 2020

1 reference

Reactivation of a major histocompatibility complex class II gene in mouse plasmacytoma cells and mouse T cells

31 March 2020

1 reference

Of mice and men: species variations of Toll-like receptor expression

31 March 2020

1 reference

Functional subsets of mouse natural killer cells

31 March 2020

1 reference

Humanized transgenic mice expressing HLA DR4-DQ3 haplotype: reconstitution of phenotype and HLA-restricted T-cell responses.

31 March 2020

1 reference

Mice lacking all conventional MHC class II genes

31 March 2020

1 reference

The third chains of living organisms--a trail of glycobiology that started from the third floor of building 4 in NIH.

31 March 2020

1 reference

Species-specific variation in glycosylation of IgG: evidence for the species-specific sialylation and branch-specific galactosylation and importance for engineering recombinant glycoprotein therapeutics

31 March 2020

1 reference

CA27.29: a valuable marker for breast cancer management. A confirmatory multicentric study on 603 cases

31 March 2020

1 reference

Serum half-life of CA 125 during early chemotherapy as an independent prognostic variable for patients with advanced epithelial ovarian cancer: results of a multicentric Italian study

31 March 2020

1 reference

Expression of a human alpha-1,3/4-fucosyltransferase in the pit cell lineage of FVB/N mouse stomach results in production of Leb-containing glycoconjugates: a potential transgenic mouse model for studying Helicobacter pylori infection

31 March 2020

1 reference

Helicobacter pylori and gastric cancer: a new paradigm for inflammation-associated epithelial cancers.

31 March 2020

1 reference

Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation

31 March 2020

1 reference

Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress

31 March 2020

1 reference

Chronic pancreatitis, pancreatic adenocarcinoma and the black box in-between

31 March 2020

1 reference

MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis

31 March 2020

1 reference

De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent

31 March 2020

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Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

31 March 2020

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Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas

31 March 2020

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Genomic instability within tumor stroma and clinicopathological characteristics of sporadic primary invasive breast carcinoma

31 March 2020

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Distinct epigenetic changes in the stromal cells of breast cancers

31 March 2020

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Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis.

31 March 2020

1 reference

Advances in imaging mouse tumour models in vivo

31 March 2020

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The use of targeted mouse models for preclinical testing of novel cancer therapeutics.

31 March 2020

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The mighty mouse: genetically engineered mouse models in cancer drug development

31 March 2020

1 reference

The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies

31 March 2020

1 reference

Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors

31 March 2020

1 reference

Retinoic acid and arsenic synergize to eradicate leukemic cells in a mouse model of acute promyelocytic leukemia

31 March 2020

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Therapy of acute promyelocytic leukemia

31 March 2020

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The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors

31 March 2020

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p48 subunit of mouse PTF1 binds to RBP-Jkappa/CBF-1, the intracellular mediator of Notch signalling, and is expressed in the neural tube of early stage embryos

31 March 2020

1 reference

Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer

31 March 2020

1 reference

Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells

31 March 2020

1 reference

Delivery of the Cre recombinase by a self-deleting lentiviral vector: efficient gene targeting in vivo

31 March 2020

1 reference

Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids

31 March 2020

1 reference

High-efficiency FLP and PhiC31 site-specific recombination in mammalian cells.

31 March 2020

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High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP

31 March 2020

1 reference

A direct comparison of two nonviral gene therapy vectors for somatic integration: in vivo evaluation of the bacteriophage integrase phiC31 and the Sleeping Beauty transposase

31 March 2020

1 reference

Mouse reporter strain for noninvasive bioluminescent imaging of cells that have undergone Cre-mediated recombination.

31 March 2020

1 reference

Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model

31 March 2020

1 reference

Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production

31 March 2020

1 reference

In vivo imaging of NF-kappa B activity

31 March 2020

1 reference

Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model

31 March 2020

1 reference

Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo

31 March 2020

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Mutation in the mismatch repair gene Msh6 causes cancer susceptibility

31 March 2020

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Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

31 March 2020

1 reference

Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis.

31 March 2020

1 reference

Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

31 March 2020

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Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

31 March 2020

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Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

31 March 2020

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Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis.

31 March 2020

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Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer

31 March 2020

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Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas

31 March 2020

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Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

31 March 2020

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Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer

31 March 2020

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Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways.

31 March 2020

1 reference

Synergistic function of Smad4 and PTEN in suppressing forestomach squamous cell carcinoma in the mouse.

31 March 2020

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A mouse model of human oral-esophageal cancer

31 March 2020

1 reference

Hyperactivation of Ha-ras oncogene, but not Ink4a/Arf deficiency, triggers bladder tumorigenesis

31 March 2020

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Apc deficiency predisposes to renal carcinoma in the mouse

31 March 2020

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Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation.

31 March 2020

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Dose-dependent effects of platelet-derived growth factor-B on glial tumorigenesis

31 March 2020

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Carcinogenesis in mouse stomach by simultaneous activation of the Wnt signaling and prostaglandin E2 pathway.

31 March 2020

1 reference

An Xpd mouse model for the combined xeroderma pigmentosum/Cockayne syndrome exhibiting both cancer predisposition and segmental progeria

31 March 2020

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De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine.

31 March 2020

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Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

31 March 2020

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A transgenic mouse model for the ductal carcinoma in situ (DCIS) of the mammary gland

31 March 2020

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Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

31 March 2020

1 reference

Conditional expression of human 15-lipoxygenase-1 in mouse prostate induces prostatic intraepithelial neoplasia: the FLiMP mouse model.

31 March 2020

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Conditional loss of Nkx3.1 in adult mice induces prostatic intraepithelial neoplasia

31 March 2020

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Dual functions of E2F-1 in a transgenic mouse model of liver carcinogenesis

31 March 2020

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Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor

31 March 2020

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Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects

31 March 2020

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Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice.

31 March 2020

1 reference

Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion

31 March 2020

1 reference

TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRC2192

1 reference

PubMed ID

17687385

Dimensions Publication ID

3 August 2017

0 references

1 reference

PubMed ID

17687385