(Q34620177)

3 August 2017

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title

Pharmaceutical use of mouse models humanized for the xenobiotic receptor (English)

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3 August 2017

2

Ronald M Evans

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author name string

Wen Xie

series ordinal

1

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3 August 2017

publication date

1 May 2002

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3 August 2017

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3 August 2017

volume

7

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3 August 2017

issue

9

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3 August 2017

page(s)

509-515

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Human cytochromes P450: problems and prospects

3 August 2017

cites work

1 reference

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St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

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Indinavir concentrations and St John's wort.

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Acute heart transplant rejection due to Saint John's wort

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Herb-drug interactions

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The RXR heterodimers and orphan receptors

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Orphan nuclear receptors--new ligands and new possibilities.

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Nuclear receptors and lipid physiology: opening the X-files

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7 January 2021

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

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7 January 2021

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

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Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

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The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

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7 January 2021

Orphan nuclear receptors: the exotics of xenobiotics.

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P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.

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7 January 2021

Molecular mechanisms of cytochrome P-450 induction by xenobiotics: An expanded role for nuclear hormone receptors.

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BXR, an embryonic orphan nuclear receptor activated by a novel class of endogenous benzoate metabolites.

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Humanized xenobiotic response in mice expressing nuclear receptor SXR.

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The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

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7 January 2021

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

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7 January 2021

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

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7 January 2021

Update on rifampin drug interactions. II.

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Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction

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7 January 2021

Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes

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7 January 2021

Peptide mimetic HIV protease inhibitors are ligands for the orphan receptor SXR.

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7 January 2021

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

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7 January 2021

Proposed role of drug-metabolizing enzymes: regulation of steady state levels of the ligands that effect growth, homeostasis, differentiation, and neuroendocrine functions

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7 January 2021

Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

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7 January 2021

Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta

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7 January 2021

Characterization of phenobarbital-inducible mouse Cyp2b10 gene transcription in primary hepatocytes.

1 reference

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7 January 2021

Activation by diverse xenochemicals of the 51-base pair phenobarbital-responsive enhancer module in the CYP2B10 gene

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7 January 2021

Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

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7 January 2021

The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR

1 reference

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7 January 2021

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

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7 January 2021

Phenobarbital response elements of cytochrome P450 genes and nuclear receptors

1 reference

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7 January 2021

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

1 reference

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7 January 2021

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

1 reference

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7 January 2021

10.1016/S1359-6446(02)02251-1

Identifiers

DOI

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3 August 2017

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