(Q33852350)

29 July 2017

title

Phenotypic screening of phylomer peptide libraries derived from genome fragments to identify and validate new targets and therapeutics (English)

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29 July 2017

Paul M Watt

1

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29 July 2017

publication date

1 May 2009

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Future Medicinal Chemistry

29 July 2017

published in

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29 July 2017

volume

1

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29 July 2017

issue

2

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29 July 2017

page(s)

257-265

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29 July 2017

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Drug discovery: a historical perspective

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How many drug targets are there?

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Advances in chemical genetics

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Chemical substructures that enrich for biological activity

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Molecular conformation and biological activity of central nervous system active drugs

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Chemogenomic identification of Ref-1/AP-1 as a therapeutic target for asthma

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Identification of potent Ras signaling inhibitors by pathway-selective phenotype-based screening

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Phenotype-first screening for the identification of novel drug targets

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High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications

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Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

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Small-molecule screening and profiling by using automated microscopy

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Target-oriented and diversity-oriented organic synthesis in drug discovery

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Towards the optimal screening collection: a synthesis strategy

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A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

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Genetic selection of peptide aptamers that recognize and inhibit cyclin-dependent kinase 2.

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Genetic selection for dissociative inhibitors of designated protein-protein interactions

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Dominant effector genetics in mammalian cells

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Cellular Localization and Antiproliferative Effect of Peptides Discovered from a Functional Screen of a Retrovirally Delivered Random Peptide Library

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Phage display of random peptide libraries: applications, limits, and potential

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Rapid discovery of protein interactions by cell-free protein technologies

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1 reference

21 January 2018

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A hierarchical approach to protein molecular evolution

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Novel folded protein domains generated by combinatorial shuffling of polypeptide segments

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More than the sum of their parts: on the evolution of proteins from peptides

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On the evolution of protein folds: are similar motifs in different protein folds the result of convergence, insertion, or relics of an ancient peptide world?

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Screening for peptide drugs from the natural repertoire of biodiverse protein folds

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Protein silencing with Phylomers: a new tool for target validation and generating lead biologicals targeting protein interactions

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Protein transduction technology

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Protein transduction: cell penetrating peptides and their therapeutic applications

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Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

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Engineering novel binding proteins from nonimmunoglobulin domains

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The tandem affinity purification (TAP) method: a general procedure of protein complex purification

21 January 2018

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A generic protein purification method for protein complex characterization and proteome exploration

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Comprehensive survey of combinatorial library synthesis: 1998.

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What If There Are Only 30,000 Human Genes?

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21 January 2018

Identifiers

DOI

10.4155/FMC.09.28

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29 July 2017

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