(Q28260664)

Initial sequencing and analysis of the human genome

21 April 2017

1 reference

High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications

21 April 2017

1 reference

The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2

21 April 2017

1 reference

Novel functions of the phosphatidylinositol metabolic pathway discovered by a chemical genomics screen with wortmannin

21 April 2017

1 reference

A planning strategy for diversity-oriented synthesis

21 April 2017

1 reference

Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol

21 April 2017

1 reference

The protein tyrosine kinase family of the human genome

21 April 2017

1 reference

Gene expression profiles derived from fine needle aspiration correlate with response to systemic chemotherapy in breast cancer

21 April 2017

1 reference

Identification of mitogen-activated protein kinase kinase as a chemoresistant pathway in MCF-7 cells by using gene expression microarray

21 April 2017

1 reference

Systematic variation in gene expression patterns in human cancer cell lines

21 April 2017

1 reference

Hit and lead generation: beyond high-throughput screening

21 April 2017

1 reference

From Knowing to Controlling: A Path from Genomics to Drugs Using Small Molecule Probes

21 April 2017

1 reference

Gene ontology: tool for the unification of biology

21 April 2017

1 reference

TTD: Therapeutic Target Database

21 April 2017

1 reference

Chemogenomic approaches to drug discovery

21 April 2017

1 reference

21 April 2017

1 reference

Basic local alignment search tool

21 April 2017

1 reference

Cancer. Addiction to oncogenes--the Achilles heal of cancer

21 April 2017

1 reference

A gene expression database for the molecular pharmacology of cancer

21 April 2017

1 reference

Targeted therapies for the treatment of cancer

21 April 2017

1 reference

Miniaturized HTS technologies - uHTS.

21 January 2018

1 reference

Chemical genetics: ligand-based discovery of gene function

21 January 2018

1 reference

Frontiers in chemical genetics

21 January 2018

1 reference

Designing screens: how to make your hits a hit.

21 January 2018

1 reference

Emerging trends in high-throughput screening

21 January 2018

1 reference

Identification of potent Ras signaling inhibitors by pathway-selective phenotype-based screening

21 January 2018

1 reference

High-density miniaturized thermal shift assays as a general strategy for drug discovery

21 January 2018

1 reference

Analysis and screening of combinatorial libraries using mass spectrometry

21 January 2018

1 reference

A chemical genomics approach toward understanding the global functions of the target of rapamycin protein (TOR).

21 January 2018

1 reference

Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin.

21 January 2018

1 reference

Structure-based screening of low-affinity compounds

21 January 2018

1 reference

Chemogenomics: bridging a drug discovery gap.

21 January 2018

1 reference

Library design practices for success in lead generation with small molecule libraries

21 January 2018

1 reference

Biological Mechanism Profiling Using an Annotated Compound Library

21 January 2018

1 reference

Chemogenomics with peptide secondary structure mimetics

21 January 2018

1 reference

Modern methods to produce natural-product libraries

21 January 2018

1 reference

Chemogenomic profiling: identifying the functional interactions of small molecules in yeast

21 January 2018

1 reference

Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2.

21 January 2018

1 reference

Depudecin induces morphological reversion of transformed fibroblasts via the inhibition of histone deacetylase

21 January 2018

1 reference

Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report

21 January 2018

1 reference

A phase I trial of depsipeptide (FR901228) in patients with advanced cancer.

21 January 2018

1 reference

Chemogenomic identification of Ref-1/AP-1 as a therapeutic target for asthma

21 January 2018

1 reference

Chemical genomics in the global study of protein functions

21 January 2018

1 reference

The multistep nature of cancer

21 January 2018

1 reference

Gene expression and amplification in breast carcinoma cells with intrinsic and acquired doxorubicin resistance

21 January 2018

1 reference

Chemosensitivity prediction by transcriptional profiling

21 January 2018

1 reference

An information-intensive approach to the molecular pharmacology of cancer.

21 January 2018

1 reference

Mining functional relationships in feature subspaces from gene expression profiles and drug activity profiles

21 January 2018

1 reference

Discovering functional relationships between RNA expression and chemotherapeutic susceptibility using relevance networks

21 January 2018

1 reference

Pharmacogenomic analysis: correlating molecular substructure classes with microarray gene expression data

21 January 2018

1 reference

Correlation between protein and mRNA abundance in yeast

21 January 2018

1 reference

Analysis of a large structure/biological activity data set using recursive partitioning

21 January 2018

1 reference

Analysis of large screening data sets via adaptively grown phylogenetic-like trees.

21 January 2018

1 reference

Extraction of pharmacophore information from high-throughput screens

21 January 2018

1 reference

Visual and computational analysis of structure--activity relationships in high-throughput screening data.

21 January 2018

1 reference

Maximum common subgraph isomorphism algorithms for the matching of chemical structures

21 January 2018

1 reference

LeadScope: software for exploring large sets of screening data

21 January 2018

1 reference

Combinatorial informatics in the post-genomics ERA.

21 January 2018

1 reference

Ontologies for proteomics: towards a systematic definition of structure and function that scales to the genome level

21 January 2018

1 reference

An ontology for biological function based on molecular interactions

21 January 2018

1 reference

Developing tools and standards in molecular informatics. Interview by Susan Aldridge.

21 January 2018

1 reference

ADME-AP: a database of ADME associated proteins.

21 January 2018

1 reference

Internet resources for proteins associated with drug therapeutic effects, adverse reactions and ADME.

21 January 2018

1 reference

In silico identification of novel therapeutic targets

21 January 2018

1 reference

21 January 2018

1 reference

Reporter gene assays and their applications to bioassays of natural products.

21 January 2018

1 reference

Automated analysis of patterns in fluorescence-microscope images

21 January 2018

1 reference

Integration of virtual and high-throughput screening

21 January 2018

1 reference

Molecular descriptors in chemoinformatics, computational combinatorial chemistry, and virtual screening

21 January 2018

1 reference

High-throughput docking for lead generation

21 January 2018

1 reference

Discovery of diverse thyroid hormone receptor antagonists by high-throughput docking

21 January 2018

1 reference

Discovery of a potent and selective protein kinase CK2 inhibitor by high-throughput docking

21 January 2018

1 reference

Virtual screening and fast automated docking methods.

21 January 2018

1 reference

Design, docking, and evaluation of multiple libraries against multiple targets

21 January 2018

1 reference

Can an in silico drug-target search method be used to probe potential mechanisms of medicinal plant ingredients?

21 January 2018

1 reference

Utilising structural knowledge in drug design strategies: applications using Relibase.

21 January 2018

1 reference

An ontology for pharmaceutical ligands and its application for in silico screening and library design

21 January 2018

1 reference

FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics

21 January 2018

1 reference

Screening in a cell-based assay for inhibitors of microglial nitric oxide production reveals calmodulin-regulated protein kinases as potential drug discovery targets

21 January 2018

1 reference

High-throughput screening for the identification of small-molecule inhibitors of retinoblastoma protein phosphorylation in cells

21 January 2018

1 reference

Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based on functional genomics knowledge

21 January 2018

1 reference

Discovery of Inhibitors that Elucidate the Role of UCH-L1 Activity in the H1299 Lung Cancer Cell Line

21 January 2018

1 reference

Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in Friend leukemic cells.

21 January 2018

1 reference

Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation

21 January 2018

1 reference

A small-molecule inhibitor of the ribonucleolytic activity of human angiogenin that possesses antitumor activity.

21 January 2018

1 reference

Virtual screening to enrich hit lists from high-throughput screening: a case study on small-molecule inhibitors of angiogenin.

21 January 2018

1 reference

Molecular modes of action of artesunate in tumor cell lines.

21 January 2018

1 reference

Radicicol Binds and Inhibits Mammalian ATP Citrate Lyase

21 January 2018

1 reference

Protein sequence analysis in silico: application of structure-based bioinformatics to genomic initiatives

21 January 2018

1 reference

Genomic sciences and the medicine of tomorrow

21 January 2018

1 reference

Application of high-throughput, molecular-targeted screening to anticancer drug discovery

31 March 2020

1 reference

SpeedScreen: label-free liquid chromatography-mass spectrometry-based high-throughput screening for the discovery of orphan protein ligands

31 March 2020

1 reference

Drug target validation and identification of secondary drug target effects using DNA microarrays

31 March 2020

1 reference

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

31 March 2020

1 reference

Chemical genomics-based target identification and validation of anti-angiogenic agents

31 March 2020

1 reference

Chemical genomics strategy for the discovery of new anticancer agents

31 March 2020

1 reference

Action of FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum no. 968, on Ha-ras transformed NIH3T3 cells

31 March 2020

1 reference

Phase I study of oral CI-994 in combination with gemcitabine in treatment of patients with advanced cancer

31 March 2020

1 reference

Molecular targets in cancer drug discovery: cell-based profiling

31 March 2020

1 reference

Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines

31 March 2020

1 reference

Identification of genes associated with sensitivity to 5-fluorouracil and cisplatin in hepatoma cells

31 March 2020

1 reference

Binary QSAR: a new method for the determination of quantitative structure activity relationships.

31 March 2020

1 reference

Application of nearest-neighbor and cluster analyses in pharmaceutical lead discovery

31 March 2020

1 reference

Ontology-based knowledge representation for bioinformatics

31 March 2020

1 reference

Protein structure similarity as guiding principle for combinatorial library design.

31 March 2020

1 reference

Drug Adverse Reaction Target Database (DART) : proteins related to adverse drug reactions

31 March 2020

1 reference

Towards a pharmacological genetics

31 March 2020

1 reference

Improved tools for biological sequence comparison

31 March 2020

1 reference

Transforming the genome to drug discovery

31 March 2020

1 reference

Structure-activity relationship homology (SARAH): a conceptual framework for drug discovery in the genomic era

31 March 2020

1 reference

Ligand-protein docking: cancer research at the interface between biology and chemistry

31 March 2020

1 reference

Identification of small-molecule inhibitors of human angiogenin and characterization of their binding interactions guided by computational docking

31 March 2020

1 reference

FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro

31 March 2020

1 reference

Creating knowledge from high-throughput screening data.

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRG1317

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

2366113

1047054246

0 references

2366113

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference