(Q33852942)

29 July 2017

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title

Virtual screening of intestinal drug permeability (English)

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29 July 2017

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Stenberg P

1

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29 July 2017

Luthman K

series ordinal

2

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29 July 2017

Artursson P

series ordinal

3

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29 July 2017

language of work or name

English

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publication date

1 March 2000

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Journal of Controlled Release

29 July 2017

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29 July 2017

65

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29 July 2017

231-243

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29 July 2017

1-2

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

29 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Prodrugs revisited: the "ad hoc" approach as a complement to ligand design

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Automated absorption assessment using Caco-2 cells cultured on both sides of polycarbonate membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Use of Caco-2 cells and LC/MS/MS to screen a peptide combinatorial library for permeable structures

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

In vitro permeability through caco-2 cells is not quantitatively predictive of in vivo absorption for peptide-like drugs absorbed via the dipeptide transporter system

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Evaluation of dynamic polar molecular surface area as predictor of drug absorption: comparison with other computational and experimental predictors

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

A practitioner's perspective of the role of quantitative structure-activity analysis in medicinal chemistry

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Convective solvent flow across the skin during iontophoresis

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

The relationship between rat intestinal permeability and hydrophilic probe size.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Functional and molecular characteristics of Na(+)-dependent nucleoside transporters.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Carrier-mediated intestinal transport of drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

pH-dependent and carrier-mediated transport of salicylic acid across Caco-2 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Transport of celiprolol across human intestinal epithelial (Caco-2) cells: mediation of secretion by multiple transporters including P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Carrier-mediated intestinal absorption of valacyclovir, the L-valyl ester prodrug of acyclovir: 1. Interactions with peptides, organic anions and organic cations in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Characterization of the regional intestinal kinetics of drug efflux in rat and human intestine and in Caco-2 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Possible involvement of multiple P-glycoprotein-mediated efflux systems in the transport of verapamil and other organic cations across rat intestine

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Jejunal absorption and metabolism of R/S-verapamil in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

P-Glycoprotein (P-gp) mediated efflux in Caco-2 cell monolayers: the influence of culturing conditions and drug exposure on P-gp expression levels.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Unexpected effect of verapamil on oral bioavailability of the beta-blocker talinolol in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Oral cyclacillin interacts with the absorption of oral ampicillin, amoxycillin, and bacampicillin.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

The effect of L-leucine on the absorption of levodopa, studied by regional jejunal perfusion in man.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Long-term intraduodenal infusion of a water based levodopa-carbidopa dispersion in very advanced Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Contribution of solvent drag through intercellular junctions to absorption of nutrients by the small intestine of the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Does fluid flow across the intestinal mucosa affect quantitative oral drug absorption? Is it time for a reevaluation?

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Modulation of the tight junctions of the Caco-2 cell monolayers by H2-antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Estimation of the relative contribution of the transcellular and paracellular pathway to the transport of passively absorbed drugs in the Caco-2 cell culture model

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Intestinal absorption barriers and transport mechanisms, including secretory transport, for a cyclic peptide, fibrinogen antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Conditionally immortalized intestinal epithelial cells: novel approach for study of differentiated enterocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Correlating partitioning and caco-2 cell permeability of structurally diverse small molecular weight compounds.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Transport of the antibacterial agent oxazolidin-2-one and derivatives across intestinal (Caco-2) and renal (MDCK) epithelial cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Correlation of drug absorption with molecular surface properties

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Calculation of hydrophobic constant (log P) from .pi. and f constants

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Lipophilicity in molecular modeling

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Comparative evaluation of the predictive power of calculation procedures for molecular lipophilicity

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

The nature of the hydrophobic binding of small peptides at the bilayer interface: implications for the insertion of transbilayer helices

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

A computer perspective of membranes: molecular dynamics studies of lipid bilayer systems

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Prediction of membrane permeability to peptides from calculated dynamic molecular surface properties

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Hydrogen bonding potential as a determinant of the in vitro and in situ blood-brain barrier permeability of peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Development of a stable freeze-dried formulation of recombinant human interleukin-1 receptor antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

QSAR analysis of membrane permeability to organic compounds.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Polar molecular surface properties predict the intestinal absorption of drugs in humans.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Descriptors for amino acids using MolSurf parametrization

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Theoretical calculation and prediction of Caco-2 cell permeability using MolSurf parametrization and PLS statistics

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Theoretical calculation and prediction of intestinal absorption of drugs in humans using MolSurf parametrization and PLS statistics

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Prediction of the intestinal absorption of endothelin receptor antagonists using three theoretical methods of increasing complexity

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Accessible surface areas as a measure of the thermodynamic parameters of hydration of peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Predicting drug absorption from molecular surface properties based on molecular dynamics simulations

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Prediction of intestinal drug absorption properties by three-dimensional solubility parameters

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

Prediction of human intestinal absorption of drug compounds from molecular structure.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-3659%2899%2900239-4

7 January 2021

10.1016/S0168-3659(99)00239-4

Identifiers

DOI

1 reference

29 July 2017

1 reference