(Q33858449)

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ARHI (DIRAS3) induces autophagy in ovarian cancer cells by downregulating the epidermal growth factor receptor, inhibiting PI3K and Ras/MAP signaling and activating the FOXo3a-mediated induction of Rab7

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29 July 2017

ARHI (DIRAS3) induces autophagy in ovarian cancer cells by downregulating the epidermal growth factor receptor, inhibiting PI3K and Ras/MAP signaling and activating the FOXo3a-mediated induction of Rab7 (English)

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29 July 2017

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Margie N Sutton

3

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1 June 2020

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1 June 2020

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Z Lu

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1 June 2020

H Yang

2

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1 June 2020

M Yang

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1 June 2020

C H Clarke

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1 June 2020

W S-L Liao

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1 June 2020

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25 April 2014

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29 July 2017

Cell Death & Differentiation

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1 June 2020

21

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1 June 2020

8

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1 June 2020

1275-1289

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1 June 2020

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11 June 2022

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https://scigraph.springernature.com/pub.10.1038/cdd.2014.48

0 references

The PI3K/AKT/mTOR signaling pathway is overactivated in primary aldosteronism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

Inhibitory effect of ARHI on pancreatic cancer cells and NF-κB activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

Effect of ARHI on lung cancer cell proliferation, apoptosis and invasion in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

Class IA phosphatidylinositol 3-kinase p110α regulates phagosome maturation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

Effects of ARHI on cell cycle progression and apoptosis levels of breast cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

Inhibition of mTOR kinase by AZD8055 can antagonize chemotherapy-induced cell death through autophagy induction and down-regulation of p62/sequestosome 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

Met receptor: a moving target

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

The tumor-suppressor gene ARHI (DIRAS3) suppresses ovarian cancer cell migration through inhibition of the Stat3 and FAK/Rho signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

Decitabine and suberoylanilide hydroxamic acid (SAHA) inhibit growth of ovarian cancer cell lines and xenografts while inducing expression of imprinted tumor suppressor genes, apoptosis, G2/M arrest, and autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

Imprinted tumor suppressor gene ARHI induces apoptosis correlated with changes in DNA methylation in pancreatic cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

Deciphering the role of forkhead transcription factors in cancer therapy

1 reference

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5 July 2018

Study of the PDK1/AKT signaling pathway using selective PDK1 inhibitors, HCS, and enhanced biochemical assays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

Akt-FOXO3a signaling axis dysregulation in human oral squamous cell carcinoma and potent efficacy of FOXO3a-targeted gene therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

Effects of Longevinex (modified resveratrol) on cardioprotection and its mechanisms of action

1 reference

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5 July 2018

MicroRNAs 221/222 and genistein-mediated regulation of ARHI tumor suppressor gene in prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

Constitutively nuclear FOXO3a localization predicts poor survival and promotes Akt phosphorylation in breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

Autophagy in C. elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

FoxO transcription factors promote autophagy in cardiomyocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

Altered mechanosensitive properties of vagal afferent fibers innervating the stomach following gastric surgery in rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

Oncogenic HRAS mutations cause prolonged PI3K signaling in response to epidermal growth factor in fibroblasts of patients with Costello syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

The role of autophagy in mammalian development: cell makeover rather than cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

Survey of differentially methylated promoters in prostate cancer cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

Methylation discriminators in NSCLC identified by a microarray based approach

1 reference

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5 July 2018

Sulforhodamine B assay and chemosensitivity

1 reference

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5 July 2018

c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

Silencing of the maternally imprinted tumor suppressor ARHI contributes to follicular thyroid carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

Role for Rab7 in maturation of late autophagic vacuoles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

ARHI is a Ras-related small G-protein with a novel N-terminal extension that inhibits growth of ovarian and breast cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

Akt activation promotes degradation of tuberin and FOXO3a via the proteasome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

Human VPS34 is required for internal vesicle formation within multivesicular endosomes

1 reference

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5 July 2018

The FYVE domain of early endosome antigen 1 is required for both phosphatidylinositol 3-phosphate and Rab5 binding. Critical role of this dual interaction for endosomal localization

1 reference

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5 July 2018

NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

5 July 2018

Duplication of Glu37 in the switch I region of HRAS impairs effector/GAP binding and underlies Costello syndrome by promoting enhanced growth factor-dependent MAPK and AKT activation

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2014.48

21 January 2018

A novel endocytic recycling signal that distinguishes the membrane trafficking of naturally occurring opioid receptors

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2014.48

21 January 2018

Rab7 is required for the normal progression of the autophagic pathway in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2014.48

21 January 2018

Vertical inhibition of the PI3K/Akt/mTOR pathway for the treatment of osteoarthritis.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2014.48

21 January 2018

The expression and prognosis of FOXO3a and Skp2 in human ovarian cancer

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2014.48

21 January 2018

LOH at 1p31 (ARHI) and proliferation in lymph node-negative breast cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4085535

29 October 2018

Expression of the tumor suppressor gene ARHI in epithelial ovarian cancer is associated with increased expression of p21WAF1/CIP1 and prolonged progression-free survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/24769729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[A G-quadruplex ligand SYUIQ-5 induces autophagy by inhibiting the Akt-FOXO3a pathway in nasopharyngeal cancer cells]

1 reference

https://pubmed.ncbi.nlm.nih.gov/24769729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1038/CDD.2014.48

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24769729%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24769729%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24769729%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

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