(Q42445553)

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Oncogenic HRAS mutations cause prolonged PI3K signaling in response to epidermal growth factor in fibroblasts of patients with Costello syndrome

scientific article published on March 2009

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

31 October 2017

Oncogenic HRAS mutations cause prolonged PI3K signaling in response to epidermal growth factor in fibroblasts of patients with Costello syndrome (English)

1 reference

Europe PubMed Central

PubMed publication ID

31 October 2017

Kerstin Kutsche

3

object named as

Kerstin Kutsche

1 reference

Europe PubMed Central

PubMed publication ID

31 October 2017

author name string

Georg Rosenberger

1

1 reference

Europe PubMed Central

PubMed publication ID

31 October 2017

Stefanie Meien

2

1 reference

Europe PubMed Central

PubMed publication ID

31 October 2017

publication date

1 March 2009

1 reference

Europe PubMed Central

PubMed publication ID

31 October 2017

1 reference

Europe PubMed Central

PubMed publication ID

31 October 2017

30

1 reference

Europe PubMed Central

PubMed publication ID

31 October 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

31 October 2017

352-362

1 reference

Europe PubMed Central

PubMed publication ID

31 October 2017

Epidermal growth factor regulates the exchange rate of guanine nucleotides on p21ras in fibroblasts

1 reference

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21 January 2018

HRAS mutations in Costello syndrome: detection of constitutional activating mutations in codon 12 and 13 and loss of wild-type allele in malignancy.

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21 January 2018

Dominant inhibitory mutations in the Mg(2+)-binding site of RasH prevent its activation by GTP

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21 January 2018

Tumor predisposition in Costello syndrome

1 reference

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21 January 2018

HRAS mutation analysis in Costello syndrome: genotype and phenotype correlation.

1 reference

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21 January 2018

Myocardial storage of chondroitin sulfate-containing moieties in Costello syndrome patients with severe hypertrophic cardiomyopathy.

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21 January 2018

Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis

1 reference

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21 January 2018

Germline mutations in HRAS proto-oncogene cause Costello syndrome

1 reference

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7 January 2021

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The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice

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The phosphoinositide 3-kinase pathway

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7 January 2021

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Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice

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Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras.

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7 January 2021

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Mutation analysis in Costello syndrome: functional and structural characterization of the HRAS p.Lys117Arg mutation

1 reference

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7 January 2021

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Biological and biochemical properties of human rasH genes mutated at codon 61.

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7 January 2021

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The importance of being K-Ras

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Protein kinase B/Akt at a glance

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The many roads that lead to Ras.

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7 January 2021

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SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases

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Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation

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Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras

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7 January 2021

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Role of glutamine-61 in the hydrolysis of GTP by p21H-ras: an experimental and theoretical study.

1 reference

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7 January 2021

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Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules

1 reference

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7 January 2021

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Oncogenic Ras in tumour progression and metastasis

1 reference

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7 January 2021

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Growth factor-dependent activation of the Ras-Raf-MEK-MAPK pathway in the human pancreatic carcinoma cell line PANC-1 carrying activated K-ras: implications for cell proliferation and cell migration

1 reference

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7 January 2021

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Repression of mitogen-activated protein kinases ERK1/ERK2 activity by a protein tyrosine phosphatase in rat fibroblasts transformed by upstream oncoproteins

1 reference

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7 January 2021

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Five additional Costello syndrome patients with rhabdomyosarcoma: proposal for a tumor screening protocol

1 reference

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7 January 2021

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Guanine nucleotide exchange factors operate by a simple allosteric competitive mechanism

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20855

7 January 2021

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Raf-1 kinase is required for cardiac hypertrophy and cardiomyocyte survival in response to pressure overload

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20855

7 January 2021

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Costello syndrome: an overview

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20855

7 January 2021

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Decreased elastin deposition and high proliferation of fibroblasts from Costello syndrome are related to functional deficiency in the 67-kD elastin-binding protein

1 reference

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7 January 2021

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Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice.

1 reference

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7 January 2021

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Lack of constitutive activation of MAP kinase pathway in human acute myeloid leukemia cells with N-Ras mutation

1 reference

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7 January 2021

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Molecular characterization of Patched-associated rhabdomyosarcoma.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20855

7 January 2021

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Genotype-phenotype correlation in Costello syndrome: HRAS mutation analysis in 43 cases.

1 reference

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7 January 2021

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Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules

1 reference

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7 January 2021

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Transformation potential of Ras isoforms correlates with activation of phosphatidylinositol 3-kinase but not ERK.

1 reference

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7 January 2021

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Further delineation of cardiac abnormalities in Costello syndrome

1 reference

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7 January 2021

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AKT/PKB signaling: navigating downstream

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7 January 2021

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Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart

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7 January 2021

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Comparative biochemical properties of normal and activated human ras p21 protein

1 reference

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7 January 2021

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Formation of a Transition-State Analog of the Ras GTPase Reaction by Ras GDP, Tetrafluoroaluminate, and GTPase-Activating Proteins

1 reference

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7 January 2021

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Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome

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7 January 2021

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Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy

1 reference

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7 January 2021

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Germline gain-of-function mutations in RAF1 cause Noonan syndrome

1 reference

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7 January 2021

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The cardiofaciocutaneous syndrome

1 reference

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7 January 2021

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Phosphatidylinositol-3-OH kinase as a direct target of Ras

1 reference

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7 January 2021

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Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

1 reference

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7 January 2021

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Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome

1 reference

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7 January 2021

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The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

1 reference

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7 January 2021

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GTPase activating proteins: structural and functional insights 18 years after discovery

1 reference

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7 January 2021

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Hyperactive Ras in developmental disorders and cancer

1 reference

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7 January 2021

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Mutation and phenotypic spectrum in patients with cardio-facio-cutaneous and Costello syndrome.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.20855

7 January 2021

based on heuristic

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Biological properties of human c-Ha-ras1 genes mutated at codon 12.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The conserved phosphoinositide 3-kinase pathway determines heart size in mice

1 reference

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7 January 2021

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Akt/protein kinase B promotes organ growth in transgenic mice

1 reference

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7 January 2021

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Opposing effects of mutant ras oncoprotein on human fibroblast and epithelial cell proliferation: implications for models of human tumorigenesis

1 reference

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7 January 2021

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Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor

1 reference

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7 January 2021

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The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity.

1 reference

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7 January 2021

based on heuristic

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Prognostic significance of activated AKT expression in soft-tissue sarcoma.

1 reference

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7 January 2021

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Myopathy caused by HRAS germline mutations: implications for disturbed myogenic differentiation in the presence of constitutive HRas activation

1 reference

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7 January 2021

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Recurring HRAS mutation G12S in Dutch patients with Costello syndrome.

1 reference

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7 January 2021

based on heuristic

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The guanine nucleotide-binding switch in three dimensions

1 reference

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7 January 2021

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Calmodulin binds to K-Ras, but not to H- or N-Ras, and modulates its downstream signaling

1 reference

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7 January 2021

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Levels of PTEN protein modulate Akt phosphorylation on serine 473, but not on threonine 308, in IGF-II-overexpressing rhabdomyosarcomas cells

1 reference

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7 January 2021

based on heuristic

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The RAF proteins take centre stage

1 reference

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7 January 2021

based on heuristic

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Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase

1 reference

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7 January 2021

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Diversity, parental germline origin, and phenotypic spectrum of de novoHRASmissense changes in Costello syndrome

1 reference

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7 January 2021

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Identifiers

10.1002/HUMU.20855

1 reference

Europe PubMed Central

PubMed publication ID

31 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 October 2017

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