(Q33868796)

29 July 2017

title

Route to three-dimensional fragments using diversity-oriented synthesis (English)

1 reference

29 July 2017

Alvin W Hung

1

1 reference

29 July 2017

Alex Ramek

2

1 reference

29 July 2017

Yikai Wang

3

1 reference

29 July 2017

Taner Kaya

4

1 reference

29 July 2017

J Anthony Wilson

5

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29 July 2017

Paul A Clemons

6

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29 July 2017

Damian W Young

7

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29 July 2017

language of work or name

English

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publication date

11 April 2011

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Proceedings of the National Academy of Sciences of the United States of America

29 July 2017

published in

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29 July 2017

volume

108

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29 July 2017

issue

17

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29 July 2017

page(s)

6799-6804

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The rise of fragment-based drug discovery

29 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084099

An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084099

Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084099

Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084099

Drugging challenging targets using fragment-based approaches

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084099

Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084099

From fragment to clinical candidate--a historical perspective.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084099

Towards the optimal screening collection: a synthesis strategy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084099

Fragment-based approaches to enzyme inhibition

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084099

A decade of fragment-based drug design: strategic advances and lessons learned

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084099

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084099

Drugs for bad bugs: confronting the challenges of antibacterial discovery

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084099

Small molecules: the missing link in the central dogma

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084099

Fragment-based lead discovery: leads by design

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084099

Self-selection in olefin cross-metathesis: the effect of remote functionality

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084099

ZINC--a free database of commercially available compounds for virtual screening

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084099

Exploring biology with small organic molecules

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084099

A planning strategy for diversity-oriented synthesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084099

A ‘Rule of Three’ for fragment-based lead discovery?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084099

Molecular shape diversity of combinatorial libraries: a prerequisite for broad bioactivity.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084099

High-throughput crystallography for lead discovery in drug design.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084099

Target-oriented and diversity-oriented organic synthesis in drug discovery

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084099

Recent developments in fragment-based drug discovery

28 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1015271108

A small molecule that binds Hedgehog and blocks its signaling in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1015271108

Oxyma: an efficient additive for peptide synthesis to replace the benzotriazole-based HOBt and HOAt with a lower risk of explosion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1015271108

Synthesis of sultam scaffolds via intramolecular oxa-Michael and diastereoselective Baylis-Hillman reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1015271108

Decomposition of a key intermediate in ruthenium-catalyzed olefin metathesis reactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1015271108

Escape from flatland: increasing saturation as an approach to improving clinical success

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1015271108

The impact of aromatic ring count on compound developability--are too many aromatic rings a liability in drug design?

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1015271108

Drug discovery: A question of library design

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1015271108

Molecular diversity by design

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1015271108

Rational Molecular Design and EPC Synthesis of a Type VI beta-Turn Inducing Peptide Mimetic This work was supported by the BMBF and the Fonds der Chemischen Industrie. EPC=enantiomerically pure compound

21 January 2018

1 reference

12 December 2020

Synthesis of Cyclic Proline-Containing Peptides via Ring-Closing Metathesis

1 reference

12 December 2020

An Oligomer-Based Approach to Skeletal Diversity in Small-Molecule Synthesis

1 reference

12 December 2020

Synthesis of macrocyclic analogues of the neuroprotective agent glycyl-l-prolyl-l-glutamic acid (GPE)

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1015271108

1 reference

29 July 2017

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29 July 2017

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