(Q33876246)

29 July 2017

title

Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators (English)

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29 July 2017

14

Peter Wipf

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29 July 2017

Donna M Huryn

1

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Paul Nghiem

object named as

Paul Nghiem

11

0 references

Kay M. Brummond

3

object named as

Kay M Brummond

1 reference

29 July 2017

Jeffrey L Brodsky

2

1 reference

29 July 2017

Peter G Chambers

4

1 reference

29 July 2017

Benjamin Eyer

5

1 reference

29 July 2017

Alex W Ireland

6

1 reference

29 July 2017

Masaoki Kawasumi

7

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29 July 2017

Matthew G Laporte

8

1 reference

29 July 2017

Kayla Lloyd

9

1 reference

29 July 2017

Baptiste Manteau

10

1 reference

29 July 2017

Bettina Quade

12

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29 July 2017

Sandlin P Seguin

13

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29 July 2017

language of work or name

English

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publication date

18 April 2011

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Proceedings of the National Academy of Sciences of the United States of America

29 July 2017

published in

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29 July 2017

volume

108

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29 July 2017

issue

17

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29 July 2017

page(s)

6757-6762

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The HSP70 chaperone machinery: J proteins as drivers of functional specificity

29 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084104

Distinct biological network properties between the targets of natural products and disease genes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084104

Binding of a small molecule at a protein-protein interface regulates the chaperone activity of hsp70-hsp40.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084104

Current strategies for diversity-oriented synthesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084104

Targeting HSP70: the second potentially druggable heat shock protein and molecular chaperone?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084104

A medicinal chemist's guide to molecular interactions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084104

Heat shock protein 70 (hsp70) as an emerging drug target.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084104

Heat stress cognate 70 host protein as a potential drug target against drug resistance in hepatitis B virus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084104

Plasmodial heat shock proteins: targets for chemotherapy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084104

Pharmacological targeting of the Hsp70 chaperone

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084104

Identifying the proteins to which small-molecule probes and drugs bind in cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084104

Covalent modifiers: an orthogonal approach to drug design

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084104

Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084104

Post-translational import of protein into the endoplasmic reticulum of a trypanosome: an in vitro system for discovery of anti-trypanosomal chemical entities

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084104

Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084104

The role of polyomaviruses in human disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084104

Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084104

Anti-cancer therapeutic approaches based on intracellular and extracellular heat shock proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084104

Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084104

Hsp70 molecular chaperones: emerging roles in human disease and identification of small molecule modulators

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084104

Solution-phase synthesis of a tricyclic pyrrole-2-carboxamide discovery library applying a stetter-Paal-Knorr reaction sequence

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084104

Diversity-oriented synthesis: exploring the intersections between chemistry and biology

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084104

Small molecule modulators of endogenous and co-chaperone-stimulated Hsp70 ATPase activity.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084104

Pursuing the leadlikeness concept in pharmaceutical research.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084104

Targeting the checkpoint kinases: chemosensitization versus chemoprotection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084104

An efficient proteomics method to identify the cellular targets of protein kinase inhibitors.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084104

Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084104

Structural diversity of organic chemistry. A scaffold analysis of the CAS Registry.

5 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1015251108

A precursor-specific role for Hsp40/Hsc70 during tail-anchored protein integration at the endoplasmic reticulum

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1015251108

TBAF-catalyzed synthesis of 5-substituted 1H-tetrazoles under solventless conditions.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1015251108

ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation

21 January 2018

1 reference

12 December 2020

Rhodium(I)-catalyzed ene-allene carbocyclization strategy for the formation of azepines and oxepines

1 reference

12 December 2020

Allenes and transition metals: a diverging approach to heterocycles

1 reference

12 December 2020

Microwave-assisted intramolecular [2 + 2] Allenic cycloaddition reaction for the rapid assembly of bicyclo[4.2.0]octa-1,6-dienes and bicyclo[5.2.0]nona-1,7-dienes

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1015251108

1 reference

29 July 2017

0 references

1 reference

29 July 2017

1 reference