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Genetic analysis of cytoprotective functions supported by graded expression of Keap1
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2876677
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20404090%20AND%20SRC:MED&resulttype=core&format=json
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31 January 2020
title
Genetic analysis of cytoprotective functions supported by graded expression of Keap1
(English)
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PMC publication ID
2876677
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31 January 2020
author
Takafumi Suzuki
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3
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2876677
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31 January 2020
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Keiko Taguchi
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1
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2876677
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31 January 2020
Jonathan M Maher
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2
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2876677
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31 January 2020
Yukie Kawatani
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4
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2876677
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31 January 2020
Hozumi Motohashi
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5
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PMC publication ID
2876677
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31 January 2020
Masayuki Yamamoto
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6
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PMC publication ID
2876677
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20404090%20AND%20SRC:MED&resulttype=core&format=json
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31 January 2020
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English
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publication date
19 April 2010
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Europe PubMed Central
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2876677
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31 January 2020
published in
Molecular and Cellular Biology
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PMC publication ID
2876677
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31 January 2020
volume
30
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2876677
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20404090%20AND%20SRC:MED&resulttype=core&format=json
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31 January 2020
issue
12
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PMC publication ID
2876677
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20404090%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 January 2020
page(s)
3016-3026
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Europe PubMed Central
PMC publication ID
2876677
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20404090%20AND%20SRC:MED&resulttype=core&format=json
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31 January 2020
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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
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KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta
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28 July 2018
Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response
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28 July 2018
The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds
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28 July 2018
Nrf2 regulates the alternative first exons of CD36 in macrophages through specific antioxidant response elements
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28 July 2018
Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth.
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28 July 2018
Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity
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28 July 2018
NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis
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28 July 2018
Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway
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PubMed Central
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28 July 2018
Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide
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28 July 2018
Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism
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28 July 2018
Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer
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28 July 2018
Interferon-gamma plays protective roles in sodium arsenite-induced renal injury by up-regulating intrarenal multidrug resistance-associated protein 1 expression.
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PubMed Central
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28 July 2018
Nrf transcription factors in keratinocytes are essential for skin tumor prevention but not for wound healing
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677
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28 July 2018
Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer
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28 July 2018
trans-Stilbene oxide induces expression of genes involved in metabolism and transport in mouse liver via CAR and Nrf2 transcription factors
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PubMed Central
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28 July 2018
Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677
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28 July 2018
Nrf2-Keap1 defines a physiologically important stress response mechanism
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677
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28 July 2018
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677
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28 July 2018
Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein1 in mouse embryo fibroblasts
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677
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28 July 2018
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677
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28 July 2018
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677
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28 July 2018
An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677
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28 July 2018
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677
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28 July 2018
High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677
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28 July 2018
Regulation of glutathione synthesis.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677
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28 July 2018
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677
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28 July 2018
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677
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28 July 2018
Tissue-specific knockout of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677
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28 July 2018
NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677
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28 July 2018
Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677
retrieved
29 October 2018
Sites of alkylation of human Keap1 by natural chemoprevention agents
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677
retrieved
29 October 2018
Subcellular localization and cytoplasmic complex status of endogenous Keap1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677
retrieved
29 October 2018
L-Buthionine (S,R) sulfoximine depletes hepatic glutathione but protects against ethanol-induced liver injury.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677
retrieved
29 October 2018
Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677
retrieved
29 October 2018
Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677
retrieved
29 October 2018
Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysema
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677
retrieved
29 October 2018
Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677
retrieved
29 October 2018
Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677
retrieved
29 October 2018
Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677
retrieved
29 October 2018
Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677
retrieved
29 October 2018
Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677
retrieved
29 October 2018
Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677
retrieved
29 October 2018
Probing keratinocyte and differentiation specificity of the human K5 promoter in vitro and in transgenic mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2876677
retrieved
29 October 2018
Identifiers
DOI
10.1128/MCB.01591-09
1 reference
stated in
Europe PubMed Central
PMC publication ID
2876677
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20404090%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 January 2020
PMC publication ID
2876677
1 reference
stated in
Europe PubMed Central
PMC publication ID
2876677
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20404090%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 January 2020
PubMed publication ID
20404090
1 reference
stated in
Europe PubMed Central
PMC publication ID
2876677
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20404090%20AND%20SRC:MED&resulttype=core&format=json
retrieved
31 January 2020
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