(Q28238852)

English

Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway

scientific article (publication date: November 2007)

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scholarly article

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Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway (English)

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multiple drug resistance

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author name string

Jonathan M Maher

1

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Matthew Z Dieter

2

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Lauren M Aleksunes

3

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Angela L Slitt

4

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Grace Guo

5

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Yuji Tanaka

6

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George L Scheffer

7

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Jefferson Y Chan

8

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Jose E Manautou

9

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Ying Chen

10

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Timothy P Dalton

11

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Masayuki Yamamoto

12

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Curtis D Klaassen

13

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language of work or name

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publication date

November 2007

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46

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5

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1597-610

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Hepatic secretion of conjugated drugs and endogenous substances

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Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs

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Up-regulation of basolateral multidrug resistance protein 3 (Mrp3) in cholestatic rat liver.

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Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice

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Adaptive changes in hepatobiliary transporter expression in primary biliary cirrhosis.

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Expression of multidrug resistance protein/GS-X pump and gamma-glutamylcysteine synthetase genes is regulated by oxidative stress.

1 reference

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Multidrug resistance in cancer: role of ATP-dependent transporters

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Frequent coexpression of MRP/GS-X pump and gamma-glutamylcysteine synthetase mRNA in drug-resistant cells, untreated tumor cells, and normal mouse tissues

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Coordinate changes in expression of protective genes in drug-resistant cells

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MRP3, an organic anion transporter able to transport anti-cancer drugs

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Role of glutathione in the multidrug resistance protein 4 (MRP4/ABCC4)-mediated efflux of cAMP and resistance to purine analogues

1 reference

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MRP subfamily transporters and resistance to anticancer agents

1 reference

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Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane

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Coordinated induction of MRP/GS-X pump and gamma-glutamylcysteine synthetase by heavy metals in human leukemia cells

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Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous

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Hepatocyte-specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failure

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Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

1 reference

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21 January 2018

Regulation of gamma-glutamylcysteine synthetase subunit gene expression: insights into transcriptional control of antioxidant defenses

1 reference

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21 January 2018

Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver

1 reference

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21 January 2018

Role of Nrf2 in the regulation of the Mrp2 (ABCC2) gene

1 reference

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NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development

1 reference

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21 January 2018

Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.21831

21 January 2018

trans-Stilbene oxide induces expression of genes involved in metabolism and transport in mouse liver via CAR and Nrf2 transcription factors

1 reference

https://api.crossref.org/works/10.1002%2FHEP.21831

21 January 2018

Coordinated expression of multidrug resistance-associated proteins (Mrps) in mouse liver during toxicant-induced injury.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.21831

21 January 2018

Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence

1 reference

https://api.crossref.org/works/10.1002%2FHEP.21831

21 January 2018

Characterization of multidrug resistance-associated protein 2 in the hepatocellular disposition of 4-hydroxynonenal

1 reference

https://api.crossref.org/works/10.1002%2FHEP.21831

21 January 2018

Export pumps for glutathione S-conjugates

1 reference

https://api.crossref.org/works/10.1002%2FHEP.21831

21 January 2018

Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice

1 reference

https://api.crossref.org/works/10.1002%2FHEP.21831

21 January 2018

Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles

1 reference

https://api.crossref.org/works/10.1002%2FHEP.21831

21 January 2018

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

1 reference

https://api.crossref.org/works/10.1002%2FHEP.21831

21 January 2018

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

1 reference

https://api.crossref.org/works/10.1002%2FHEP.21831

21 January 2018

Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

1 reference

https://api.crossref.org/works/10.1002%2FHEP.21831

21 January 2018

Generation of a stable antioxidant response element-driven reporter gene cell line and its use to show redox-dependent activation of nrf2 by cancer chemotherapeutic agents.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.21831

21 January 2018

Nrf2 signaling in coordinated activation of antioxidant gene expression

1 reference

https://api.crossref.org/works/10.1002%2FHEP.21831

21 January 2018

Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene

1 reference

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Chemical and molecular regulation of enzymes that detoxify carcinogens

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Glucuronidation in humans. Pharmacogenetic and developmental aspects

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The Jun N-terminal kinase inhibitor SP600125 is a ligand and antagonist of the aryl hydrocarbon receptor

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Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network

1 reference

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Predictive base substitution rules that determine the binding and transcriptional specificity of Maf recognition elements

1 reference

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Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.21831

21 January 2018

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

1 reference

https://api.crossref.org/works/10.1002%2FHEP.21831

21 January 2018

Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.21831

21 January 2018

Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

1 reference

https://api.crossref.org/works/10.1002%2FHEP.21831

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Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein1 in mouse embryo fibroblasts

1 reference

https://api.crossref.org/works/10.1002%2FHEP.21831

21 January 2018

ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2.

1 reference

https://api.crossref.org/works/10.1002%2FHEP.21831

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Metabolism and function of glutathione: an overview

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Regulatory elements controlling the basal and drug-inducible expression of glutathione S-transferase Ya subunit gene

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https://api.crossref.org/works/10.1002%2FHEP.21831

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Hepatobiliary transport of glutathione and glutathione conjugate in rats with hereditary hyperbilirubinemia

1 reference

https://api.crossref.org/works/10.1002%2FHEP.21831

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Biochemical and molecular aspects of genetic disorders of bilirubin metabolism

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Induction of Phase I and Phase II Drug-Metabolizing Enzyme mRNA, Protein, and Activity by BHA, Ethoxyquin, and Oltipraz

1 reference

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1 reference

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