(Q33880616)

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High affinity small protein inhibitors of human chymotrypsin C (CTRC) selected by phage display reveal unusual preference for P4' acidic residues

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scholarly article

1 reference

Europe PubMed Central

29 July 2017

High affinity small protein inhibitors of human chymotrypsin C (CTRC) selected by phage display reveal unusual preference for P4' acidic residues (English)

1 reference

Europe PubMed Central

29 July 2017

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Dávid Szakács

object named as

Dávid Szakács

3

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Evette S. Radisky

object named as

Evette S Radisky

6

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Miklós Sahin-Tóth

object named as

Miklós Sahin-Tóth

7

0 references

object named as

Gábor Pál

8

0 references

Katalin Adrienna Kékesi

object named as

Katalin A Kékesi

5

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author name string

András Szabó

1

1 reference

Europe PubMed Central

29 July 2017

Dávid Héja

2

1 reference

Europe PubMed Central

29 July 2017

Katalin Zboray

4

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Europe PubMed Central

29 July 2017

language of work or name

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publication date

22 April 2011

1 reference

Europe PubMed Central

29 July 2017

Journal of Biological Chemistry

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Europe PubMed Central

29 July 2017

286

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Europe PubMed Central

29 July 2017

25

1 reference

Europe PubMed Central

29 July 2017

22535-22545

1 reference

Europe PubMed Central

29 July 2017

Chymotrypsin C is a co-activator of human pancreatic procarboxypeptidases A1 and A2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Phage display as a powerful tool to engineer protease inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Structure of Locusta migratoria protease inhibitor 3 (LMPI-3) in complex with Fusarium oxysporum trypsin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Analysis of protein processing by N-terminal proteomics reveals novel species-specific substrate determinants of granzyme B orthologs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Pacifastin-related peptides: structural and functional characteristics of a family of serine peptidase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

The RosettaDock server for local protein-protein docking

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Chymotrypsin C (caldecrin) promotes degradation of human cationic trypsin: identity with Rinderknecht's enzyme Y

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

When the surface tells what lies beneath: combinatorial phage-display mutagenesis reveals complex networks of surface-core interactions in the pacifastin protease inhibitor family.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Comprehensive and quantitative mapping of energy landscapes for protein-protein interactions by rapid combinatorial scanning

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Chymotrypsin C (caldecrin) stimulates autoactivation of human cationic trypsinogen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Enzyme:substrate hydrogen bond shortening during the acylation phase of serine protease catalysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Alternative views of functional protein binding epitopes obtained by combinatorial shotgun scanning mutagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Extended intermolecular interactions in a serine protease-canonical inhibitor complex account for strong and highly specific inhibition.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

WebLogo: A Sequence Logo Generator

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Same fold with different mobility: backbone dynamics of small protease inhibitors from the desert locust, Schistocerca gregaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Bacterial production and purification of SGPI-1 and SGPI-2, two peptidic serine protease inhibitors from the desert locust, Schistocerca gregaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

The functional binding epitope of a high affinity variant of human growth hormone mapped by shotgun alanine-scanning mutagenesis: insights into the mechanisms responsible for improved affinity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Exploring protein-protein interactions with phage display

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

A clogged gutter mechanism for protease inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Structural and functional properties of a novel serine protease inhibiting peptide family in arthropods

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Comparative structure analysis of proteinase inhibitors from the desert locust, Schistocerca gregaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Remarkable phylum selectivity of a Schistocerca gregaria trypsin inhibitor: the possible role of enzyme-inhibitor flexibility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Complexation of two proteic insect inhibitors to the active site of chymotrypsin suggests decoupled roles for binding and selectivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Phage display for selection of novel binding peptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Rapid mapping of protein functional epitopes by combinatorial alanine scanning

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Low molecular weight serine protease inhibitors from insects are proteins with highly conserved sequences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Proteinase inhibitors from desert locust, Schistocerca gregaria: engineering of both P(1) and P(1)' residues converts a potent chymotrypsin inhibitor to a potent trypsin inhibitor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

S' subsite mapping of serine proteases based on fluorescence resonance energy transfer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Purification and characterization of a group of five novel peptide serine protease inhibitors from ovaries of the desert locust, Schistocerca gregaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Stable monomeric form of an originally dimeric serine proteinase inhibitor, ecotin, was constructed via site directed mutagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Solution structure of PMP-C: a new fold in the group of small serine proteinase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Mapping the S' subsites of serine proteases using acyl transfer to mixtures of peptide nucleophiles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Amino acid sequences of ovomucoid third domains from 27 additional species of birds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Role of the S' subsites in serine protease catalysis. Active-site mapping of rat chymotrypsin, rat trypsin, alpha-lytic protease, and cercarial protease from Schistosoma mansoni.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Alteration of the specificity of ecotin, an E. coli serine proteinase inhibitor, by site directed mutagenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

The molecular structure of the complex of Ascaris chymotrypsin/elastase inhibitor with porcine elastase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

The three-dimensional structure of the native ternary complex of bovine pancreatic procarboxypeptidase A with proproteinase E and chymotrypsinogen C

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Thermodynamics and kinetics of single residue replacements in avian ovomucoid third domains: effect on inhibitor interactions with serine proteinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Rapid and efficient site-specific mutagenesis without phenotypic selection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Natural protein proteinase inhibitors and their interaction with proteinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

5 July 2018

Affinity purification of recombinant trypsinogen using immobilized ecotin.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.235754

21 January 2018

Solution structure of PMP-D2, a 35-residue peptide isolated from the insect Locusta migratoria.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.235754

21 January 2018

Stabilization of proteins by glycosylation examined by NMR analysis of a fucosylated proteinase inhibitor.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.235754

21 January 2018

Local binding with globally distributed changes in a small protease inhibitor upon enzyme binding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.235754

21 January 2018

Importance of the P4' residue in human granzyme B inhibitors and substrates revealed by scanning mutagenesis of the proteinase inhibitor 9 reactive center loop

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.235754

21 January 2018

Energetics of protein-protein interactions: analysis of the barnase-barstar interface by single mutations and double mutant cycles.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121398

29 October 2018

On subunit II of bovine procarboxypeptidase A. Enzymatic specificity after tryptic activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21515688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Converting trypsin to chymotrypsin: structural determinants of S1' specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21515688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CHYMOTRYPSIN C. I. ISOLATION OF THE ZYMOGEN AND THE ACTIVE ENZYME: PRELIMINARY STRUCTURE AND SPECIFICITY STUDIES

1 reference

https://pubmed.ncbi.nlm.nih.gov/21515688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CHYMOTRYPSIN C. II. ENZYMATIC SPECIFICITY TOWARD SEVERAL POLYPEPTIDES

1 reference

https://pubmed.ncbi.nlm.nih.gov/21515688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p-Nitrophenyl-p'-guanidinobenzoate HCl: a new active site titrant for trypsin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21515688

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.235754

1 reference

Europe PubMed Central

29 July 2017

1 reference

Europe PubMed Central

29 July 2017

1 reference

Europe PubMed Central

29 July 2017

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