(Q33881988)

29 July 2017

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title

Importance of protein dynamics during enzymatic C-H bond cleavage catalysis (English)

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29 July 2017

Judith P Klinman

1

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29 July 2017

language of work or name

English

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publication date

12 February 2013

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29 July 2017

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29 July 2017

volume

52

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29 July 2017

issue

12

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29 July 2017

page(s)

2068-2077

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Hydrogen tunneling links protein dynamics to enzyme catalysis

29 July 2017

cites work

1 reference

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5 July 2018

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Crystal structure of 12-lipoxygenase catalytic-domain-inhibitor complex identifies a substrate-binding channel for catalysis

5 July 2018

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Active site hydrophobic residues impact hydrogen tunneling differently in a thermophilic alcohol dehydrogenase at optimal versus nonoptimal temperatures

5 July 2018

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5 July 2018

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Taking Ockham's razor to enzyme dynamics and catalysis

5 July 2018

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Effects of the donor-acceptor distance and dynamics on hydride tunneling in the dihydrofolate reductase catalyzed reaction

5 July 2018

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Protein dynamics and enzymatic chemical barrier passage

5 July 2018

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Impaired protein conformational landscapes as revealed in anomalous Arrhenius prefactors

5 July 2018

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Investigating inner-sphere reorganization via secondary kinetic isotope effects in the C-H cleavage reaction catalyzed by soybean lipoxygenase: tunneling in the substrate backbone as well as the transferred hydrogen

5 July 2018

1 reference

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Seeing the forest for the trees: fluorescence studies of single enzymes in the context of ensemble experiments

5 July 2018

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Impact of distal mutation on hydrogen transfer interface and substrate conformation in soybean lipoxygenase

5 July 2018

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The role of conformational entropy in molecular recognition by calmodulin

5 July 2018

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An integrated model for enzyme catalysis emerges from studies of hydrogen tunneling

5 July 2018

1 reference

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Hidden alternative structures of proline isomerase essential for catalysis

5 July 2018

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Rational modulation of conformational fluctuations in adenylate kinase reveals a local unfolding mechanism for allostery and functional adaptation in proteins

5 July 2018

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A 21st century revisionist's view at a turning point in enzymology

5 July 2018

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Chemical achievement and hope for the future.

5 July 2018

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Conformational relaxation following hydride transfer plays a limiting role in dihydrofolate reductase catalysis

5 July 2018

1 reference

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Hydrogen-exchange mass spectrometry reveals activation-induced changes in the conformational mobility of p38alpha MAP kinase

5 July 2018

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Kemp elimination catalysts by computational enzyme design

5 July 2018

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De novo computational design of retro-aldol enzymes

5 July 2018

1 reference

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Free-energy landscape of enzyme catalysis

5 July 2018

1 reference

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Enzyme structure and dynamics affect hydrogen tunneling: The impact of a remote side chain (I553) in soybean lipoxygenase-1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091948

Intrinsic motions along an enzymatic reaction trajectory

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091948

Intrinsic disorder as a mechanism to optimize allosteric coupling in proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091948

Multidimensional tunneling, recrossing, and the transmission coefficient for enzymatic reactions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091948

Relating protein motion to catalysis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091948

Intrinsic dynamics of an enzyme underlies catalysis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091948

Thermal-activated protein mobility and its correlation with catalysis in thermophilic alcohol dehydrogenase

5 July 2018

1 reference

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The near attack conformation approach to the study of the chorismate to prephenate reaction

5 July 2018

1 reference

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Environmentally coupled hydrogen tunneling. Linking catalysis to dynamics

5 July 2018

1 reference

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Temperature-dependent isotope effects in soybean lipoxygenase-1: correlating hydrogen tunneling with protein dynamics.

5 July 2018

1 reference

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Critical analysis of antibody catalysis.

5 July 2018

1 reference

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Nature of hydrogen transfer in soybean lipoxygenase 1: separation of primary and secondary isotope effects

5 July 2018

1 reference

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Single-molecule enzymatic dynamics

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091948

Manganese lipoxygenase. Discovery of a bis-allylic hydroperoxide as product and intermediate in a lipoxygenase reaction.

5 July 2018

1 reference

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A link between protein structure and enzyme catalyzed hydrogen tunneling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091948

The expression of isotope effects on enzyme-catalyzed reactions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091948

Entropic Contributions to Rate Accelerations in Enzymic and Intramolecular Reactions and the Chelate Effect

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091948

Hydrogen tunneling in enzyme reactions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091948

Quantum variational transition state theory for hydrogen tunneling in enzyme catalysis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091948

Hydrogen tunneling steps in cyclooxygenase-2 catalysis.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091948

Biochemistry. An ensemble view of allostery.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091948

Evidence for protein radical-mediated nuclear tunneling in fatty acid alpha-oxygenase

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091948

Hydrogen tunneling in an enzyme active site: a quantum wavepacket dynamical perspective

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091948

Oxygen isotope effects on electron transfer to O2 probed using chemically modified flavins bound to glucose oxidase

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091948

Enzyme dynamics and hydrogen tunnelling in a thermophilic alcohol dehydrogenase.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091948

Lipoxygenase reaction mechanism: demonstration that hydrogen abstraction from substrate precedes dioxygen binding during catalytic turnover.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091948

Nature of Rate-Limiting Steps in the Soybean Lipoxygenase-1 Reaction

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091948

Kinetic and chemical mechanisms of yeast formate dehydrogenase.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091948

Novel insights into cyclooxygenases, linoleate diol synthases, and lipoxygenases from deuterium kinetic isotope effects and oxidation of substrate analogs

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23373460

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/BI301504M

1 reference

29 July 2017

1 reference

29 July 2017

1 reference