(Q33883721)

29 July 2017

title

The small molecule, LLL12, inhibits STAT3 phosphorylation and induces apoptosis in medulloblastoma and glioblastoma cells (English)

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29 July 2017

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Sarah Ball

1

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29 July 2017

Chenglong Li

series ordinal

2

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29 July 2017

Pui-Kai Li

series ordinal

3

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29 July 2017

Jiayuh Lin

series ordinal

4

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29 July 2017

language of work or name

English

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publication date

19 April 2011

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29 July 2017

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29 July 2017

volume

6

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29 July 2017

issue

4

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29 July 2017

page(s)

e18820

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Creative Commons Attribution 4.0 International

29 July 2017

copyright license

start time

19 April 2011

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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5 July 2018

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A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079737

STATs in cancer inflammation and immunity: a leading role for STAT3

5 July 2018

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Pediatric brain tumors: current treatment strategies and future therapeutic approaches

5 July 2018

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Novel drug delivery strategies in neuro-oncology

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079737

Malignant gliomas in adults

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079737

Glioblastoma multiforme: evidence-based approach to therapy

5 July 2018

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Design, synthesis, and studies of small molecule STAT3 inhibitors

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079737

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

5 July 2018

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Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079737

SD-1029 inhibits signal transducer and activator of transcription 3 nuclear translocation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079737

Stattic: a small-molecule inhibitor of STAT3 activation and dimerization

5 July 2018

1 reference

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The role of constitutively active signal transducer and activator of transcription 3 in ovarian tumorigenesis and prognosis

5 July 2018

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A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo

5 July 2018

1 reference

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Interleukin-6 and its receptor: from bench to bedside

5 July 2018

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IL-6 signaling via the STAT3/SOCS3 pathway: functional analysis of the conserved STAT3 N-domain

5 July 2018

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c-myc overexpression causes anaplasia in medulloblastoma

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079737

Knockdown of STAT3 expression by RNA interference inhibits the induction of breast tumors in immunocompetent mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079737

A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079737

Stat3 regulates genes common to both wound healing and cancer

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079737

Medulloblastoma: signalling a change in treatment

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079737

The STATs of cancer--new molecular targets come of age

5 July 2018

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Principles of interleukin (IL)-6-type cytokine signalling and its regulation

5 July 2018

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Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079737

Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079737

The JAK2 inhibitor AG490 predominantly abrogates the growth of human B-precursor leukemic cells with 11q23 translocation or Philadelphia chromosome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079737

Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079737

Roles of STAT3 defined by tissue-specific gene targeting

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079737

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079737

5 July 2018

The Hallmarks of Cancer

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079737

Expression of leukemia-inhibitory factor as an autocrinal growth factor in human medulloblastomas

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079737

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079737

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079737

Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079737

Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079737

Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079737

Glioblastoma multiforme in children

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3079737

Survivin is a negative prognostic marker in medulloblastoma.

5 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018820

Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018820

Investigation of the binding determinants of phosphopeptides targeted to the SRC homology 2 domain of the signal transducer and activator of transcription 3. Development of a high-affinity peptide inhibitor

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018820

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/21526200

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0018820

1 reference

29 July 2017

0 references

1 reference

29 July 2017

1 reference