(Q36495258)

14 August 2017

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title

Interleukin-6 and its receptor: from bench to bedside (English)

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14 August 2017

Stefan Rose-John

2

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author name string

Jürgen Scheller

series ordinal

1

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14 August 2017

publication date

31 May 2006

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Medical Microbiology and Immunology

14 August 2017

published in

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14 August 2017

volume

195

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14 August 2017

issue

4

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14 August 2017

page(s)

173-183

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Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells

14 August 2017

cites work

1 reference

12 December 2020

Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic stem cells

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12 December 2020

Delayed onset and reduced severity of collagen-induced arthritis in interleukin-6-deficient mice

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12 December 2020

The role of transsignalling via the agonistic soluble IL-6 receptor in human diseases

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12 December 2020

Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex

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12 December 2020

The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo.

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12 December 2020

Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation

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12 December 2020

IL-6 type cytokine receptor complexes: hexamer, tetramer or both?

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12 December 2020

Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130

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12 December 2020

The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6.

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12 December 2020

The IL-6/sIL-6R fusion protein hyper-IL-6 promotes neurite outgrowth and neuron survival in cultured enteric neurons.

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12 December 2020

A possible role for soluble IL-6 receptor in the pathogenesis of systemic onset juvenile chronic arthritis

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12 December 2020

Haemopoietic receptors and helical cytokines

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12 December 2020

Constitutive activation of STAT3 is associated with the acquisition of an interleukin 6-independent phenotype by murine plasmacytomas and hybridomas

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12 December 2020

Progressive and controlled development of mouse dendritic cells from Flt3+CD11b+ progenitors in vitro.

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12 December 2020

Interleukin-6 and the soluble interleukin-6 receptor induce stem cell factor and Flt-3L expression in vivo and in vitro

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12 December 2020

Involvement of IL-6, apart from its role in immunity, in mediating a chronic response during experimental arthritis

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12 December 2020

Concentrations and origins of soluble interleukin 6 receptor-alpha in serum and synovial fluid

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12 December 2020

Molecular biology and immunology of interleukin-6

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12 December 2020

Cellular tropism and viral interleukin-6 expression distinguish human herpesvirus 8 involvement in Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease

1 reference

12 December 2020

Dynamics of the gp130 cytokine complex: a model for assembly on the cellular membrane

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12 December 2020

Primary effusion lymphoma: a distinct clinicopathologic entity associated with the Kaposi's sarcoma-associated herpes virus.

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12 December 2020

Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells

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12 December 2020

Interleukin-6 and soluble interleukin-6 receptor: direct stimulation of gp130 and hematopoiesis

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12 December 2020

Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas

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12 December 2020

IL-6 signaling promotes tumor growth in colorectal cancer

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12 December 2020

Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

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12 December 2020

Soluble IL-6 Receptor Governs IL-6 Activity in Experimental Arthritis: Blockade of Arthritis Severity by Soluble Glycoprotein 130

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12 December 2020

Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV.

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12 December 2020

Extramedullary expansion of hematopoietic progenitor cells in interleukin (IL)-6-sIL-6R double transgenic mice

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12 December 2020

Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses

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12 December 2020

Constitutive activation of gp130 leads to neuroendocrine differentiation in vitro and in vivo

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12 December 2020

Interleukin 6 knock-out mice are resistant to antigen-induced experimental arthritis

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12 December 2020

Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial

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12 December 2020

Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells

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12 December 2020

Human herpesvirus type 8 interleukin-6 homologue is functionally active on human myeloma cells.

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12 December 2020

Soluble interleukin-6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism

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12 December 2020

Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis.

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12 December 2020

Interleukin 6 plays a key role in the development of antigen-induced arthritis

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12 December 2020

Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer

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12 December 2020

TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.

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12 December 2020

Interleukin 6 is required for the development of collagen-induced arthritis

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12 December 2020

Neural activities of IL-6-type cytokines often depend on soluble cytokine receptors

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12 December 2020

IL-6 receptor blockage inhibits the onset of autoimmune kidney disease in NZB/W F1 mice

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12 December 2020

Structure of an extracellular gp130 cytokine receptor signaling complex

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12 December 2020

Treatment of severe rheumatoid arthritis by anti-interleukin 6 monoclonal antibody

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12 December 2020

Blockade of interleukin 6 trans signaling suppresses T-cell resistanceagainst apoptosis in chronic intestinal inflammation: Evidence in Crohn diseaseand experimental colitis in vivo

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12 December 2020

The soluble interleukin-6 receptor is generated by shedding

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12 December 2020

Angiogenesis and hematopoiesis induced by Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6.

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12 December 2020

Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma

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12 December 2020

Kaposi's sarcoma-associated herpesvirus infection of bone marrow dendritic cells from multiple myeloma patients

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12 December 2020

Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease

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12 December 2020

Stat proteins and oncogenesis

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12 December 2020

Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration

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12 December 2020

Hyper-IL-6 gene therapy reverses fulminant hepatic failure.

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12 December 2020

Sympathetic neurons can produce and respond to interleukin 6

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12 December 2020

Complex of soluble human IL-6-receptor/IL-6 up-regulates expression of acute-phase proteins

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12 December 2020

Interleukin-6 modulates production of T lymphocyte–derived cytokines in antigen-induced arthritis and drives inflammation-induced osteoclastogenesis

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12 December 2020

Kaposi's sarcoma-associated herpesvirus and multiple myeloma: lack of criteria for causality

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12 December 2020

Design of effective immunotherapy for human autoimmunity

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12 December 2020

Interleukin-6 trans-signalling in chronic inflammation and cancer

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12 December 2020

IL-6 and Its Soluble Receptor Orchestrate a Temporal Switch in the Pattern of Leukocyte Recruitment Seen during Acute Inflammation

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12 December 2020

Transcriptional profiling identifies Id2 function in dendritic cell development

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12 December 2020

HHV-8 is present in multiple myeloma patients

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12 December 2020

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

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12 December 2020

Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: a randomized, double-blind, placebo-controlled, dose-escalation trial

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12 December 2020

Role of interleukin-6 and soluble IL-6 receptor in region-specific induction of astrocytic differentiation and neurotrophin expression

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12 December 2020

The effect of gp130 stimulation on glutamate-induced excitotoxicity in primary hippocampal neurons

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12 December 2020

Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)

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12 December 2020

Liver regeneration induced by a designer human IL-6/sIL-6R fusion protein reverses severe hepatocellular injury.

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12 December 2020

Endogenous interleukin-6, but not tumor necrosis factor alpha, contributes to the development of toll-like receptor 4/myeloid differentiation factor 88-mediated acute arthritis in mice.

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12 December 2020

Towards determining the differentiation program of antigen-presenting dendritic cells by transcriptional profiling

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12 December 2020

The family of the IL-6-type cytokines: specificity and promiscuity of the receptor complexes

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12 December 2020

Maintenance of pluripotency in human embryonic stem cells is STAT3 independent

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12 December 2020

IL-6 Receptor Independent Stimulation of Human gp130 by Viral IL-6

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12 December 2020

Human herpesvirus 8 encodes a homolog of interleukin-6.

1 reference

12 December 2020

Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease

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12 December 2020

A Kaposi's sarcoma-associated herpesvirus-encoded cytokine homolog (vIL-6) activates signaling through the shared gp130 receptor subunit

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12 December 2020

Pathological role of IL-6 in the experimental allergic bronchial asthma in mice

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12 December 2020

IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation.

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12 December 2020

Soluble receptors for cytokines and growth factors: generation and biological function

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12 December 2020

Interleukin-6 and the acute phase response

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12 December 2020

A form of circulating interleukin-6 receptor component soluble gp130 as a potential interleukin-6 inhibitor in inflammatory bowel disease

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12 December 2020

Hepatocellular hyperplasia, plasmacytoma formation, and extramedullary hematopoiesis in interleukin (IL)-6/soluble IL-6 receptor double-transgenic mice

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12 December 2020

Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with a humanized anti-IL-6 receptor antibody

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12 December 2020

Involvement of the acute phase protein alpha 1-acid glycoprotein in nonspecific resistance to a lethal gram-negative infection

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12 December 2020

Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis

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12 December 2020

A bioactive designer cytokine for human hematopoietic progenitor cell expansion

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12 December 2020

CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK.

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12 December 2020

IL6 signalling through IL6 receptor and receptor-associated signal transducer, gp130

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12 December 2020

A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease

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12 December 2020

Serum levels of interleukin-6 type cytokines and soluble interleukin-6 receptor in patients with rheumatoid arthritis

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12 December 2020

Viral IL-6-induced cell proliferation and immune evasion of interferon activity

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12 December 2020

Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor

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12 December 2020

Studies on the structure and regulation of the human hepatic interleukin-6 receptor

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12 December 2020

SOCS3 negatively regulates IL-6 signaling in vivo

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12 December 2020

Molecular mechanisms of cytokine receptor activation

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12 December 2020

Protein kinase C activity is rate limiting for shedding of the interleukin-6 receptor.

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12 December 2020

10.1007/S00430-006-0019-9

Identifiers

DOI

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release_crbztnn7xve5rhhohowqsg7n2a

14 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/crbztnn7xve5rhhohowqsg7n2a

24 November 2022

mapped directly with Wikidata item

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