(Q33888964)

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Key amino acid residues involved in multi-point binding interactions between brazzein, a sweet protein, and the T1R2-T1R3 human sweet receptor

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Europe PubMed Central

PubMed publication ID

29 July 2017

Key amino acid residues involved in multi-point binding interactions between brazzein, a sweet protein, and the T1R2-T1R3 human sweet receptor (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

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John L Markley

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Europe PubMed Central

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29 July 2017

Fariba M Assadi-Porter

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Fariba M Assadi-Porter

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Europe PubMed Central

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29 July 2017

author name string

Emeline L Maillet

2

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Europe PubMed Central

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29 July 2017

James T Radek

3

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Europe PubMed Central

PubMed publication ID

29 July 2017

Jeniffer Quijada

4

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Europe PubMed Central

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29 July 2017

Marianna Max

6

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Europe PubMed Central

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29 July 2017

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publication date

17 March 2010

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Europe PubMed Central

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29 July 2017

Journal of Molecular Biology

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Europe PubMed Central

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29 July 2017

398

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Europe PubMed Central

PubMed publication ID

29 July 2017

4

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Europe PubMed Central

PubMed publication ID

29 July 2017

584-599

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Interactions between the human sweet-sensing T1R2-T1R3 receptor and sweeteners detected by saturation transfer difference NMR spectroscopy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Efficient and rapid protein expression and purification of small high disulfide containing sweet protein brazzein in E. coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Curculin exhibits sweet-tasting and taste-modifying activities through its distinct molecular surfaces

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Activation of a dimeric metabotropic glutamate receptor by intersubunit rearrangement.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Taste-modifying sweet protein, neoculin, is received at human T1R3 amino terminal domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Structures of the extracellular regions of the group II/III metabotropic glutamate receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Interactions of the sweet protein brazzein with the sweet taste receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

The heterodimeric sweet taste receptor has multiple potential ligand binding sites.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Neoculin, a taste-modifying protein, is recognized by human sweet taste receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Natural sweet macromolecules: how sweet proteins work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Crystal structure of neoculin: insights into its sweetness and taste-modifying activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Brazzein, a small, sweet protein: effects of mutations on its structure, dynamics and functional properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Molecular mechanisms of sweet receptor function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Activation mechanism of the heterodimeric GABA(B) receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Different functional roles of T1R subunits in the heteromeric taste receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

The cysteine-rich region of T1R3 determines responses to intensely sweet proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Closed state of both binding domains of homodimeric mGlu receptors is required for full activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Interaction of sweet proteins with their receptor. A conformational study of peptides corresponding to loops of brazzein, monellin and thaumatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Functional interaction between T2R taste receptors and G-protein alpha subunits expressed in taste receptor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Structure of the metabotropic glutamate receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Critical regions for the sweetness of brazzein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

The mechanism of interaction of sweet proteins with the T1R2-T1R3 receptor: evidence from the solution structure of G16A-MNEI

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Structural views of the ligand-binding cores of a metabotropic glutamate receptor complexed with an antagonist and both glutamate and Gd3+.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Sweetness and enzymatic activity of lysozyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Mammalian sweet taste receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Crystal structure of rhodopsin: A G protein-coupled receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Sweetness determinant sites of brazzein, a small, heat-stable, sweet-tasting protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Efficient production of recombinant brazzein, a small, heat-stable, sweet-tasting protein of plant origin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Solution structure of the thermostable sweet-tasting protein brazzein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Synthesis and characterization of the sweet protein brazzein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Evaluating the 'Labeled Magnitude Scale' for measuring sensations of taste and smell

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Structures of heat-stable and unstable homologues of the sweet protein mabinlin. The difference in the heat stability is due to replacement of a single amino acid residue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Brazzein, a new high-potency thermostable sweet protein from Pentadiplandra brazzeana B

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Purification of monellin, the sweet principle of Dioscoreophyllum cumminsii.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Measurement of protein by spectrophotometry at 205 nm.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Determination of disulfide array and subunit structure of taste-modifying protein, miraculin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Structural determination of the active site of a sweet protein. A 1H NMR investigation of pMNEI.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

5 July 2018

Correlation of the Sweetness of Variants of the Protein Brazzein with Patterns of Hydrogen Bonds Detected by NMR Spectroscopy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

29 October 2018

Why are sweet proteins sweet? Interaction of brazzein, monellin and thaumatin with the T1R2-T1R3 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

29 October 2018

The Importance of Electrostatic Potential in The Interaction of Sweet Proteins with the Sweet Taste Receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879441

29 October 2018

Monkey electrophysiological and human psychophysical responses to mutants of the sweet protein brazzein: delineating brazzein sweetness

1 reference

https://pubmed.ncbi.nlm.nih.gov/20302879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

13C NMR chemical shifts can predict disulfide bond formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20302879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

From small sweeteners to sweet proteins: anatomy of the binding sites of the human T1R2_T1R3 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/20302879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Riboflavin-binding protein exhibits selective sweet suppression toward protein sweeteners

1 reference

https://pubmed.ncbi.nlm.nih.gov/20302879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct contributions of T1R2 and T1R3 taste receptor subunits to the detection of sweet stimuli

1 reference

https://pubmed.ncbi.nlm.nih.gov/20302879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and characterization of the sweet principle from Dioscoreophyllum cumminsii (stapf) Diels

1 reference

https://pubmed.ncbi.nlm.nih.gov/20302879

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.JMB.2010.03.017

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

ResearchGate publication ID

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