(Q33894613)

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Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu₅).

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scholarly article

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Europe PubMed Central

29 July 2017

Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu₅). (English)

1 reference

Europe PubMed Central

29 July 2017

Craig W. Lindsley

23

object named as

Craig W Lindsley

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Europe PubMed Central

29 July 2017

P. Jeffrey Conn

22

object named as

P Jeffrey Conn

1 reference

Europe PubMed Central

29 July 2017

Colleen M. Niswender

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object named as

Colleen M Niswender

1 reference

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29 July 2017

Shaun R Stauffer

24

object named as

Shaun R Stauffer

1 reference

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29 July 2017

Hilde Lavreysen

9

object named as

Hilde Lavreysen

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29 July 2017

10

object named as

Claire Mackie

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29 July 2017

Susana Conde-Ceide

12

object named as

Susana Conde-Ceide

1 reference

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29 July 2017

José M Bartolomé-Nebreda

11

object named as

José M Bartolomé-Nebreda

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Europe PubMed Central

29 July 2017

Thomas Steckler

17

object named as

Thomas Steckler

1 reference

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29 July 2017

Meredith J Noetzel

5

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Meredith J Noetzel

1 reference

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29 July 2017

Mark Turlington

1

object named as

Mark Turlington

1 reference

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29 July 2017

4

object named as

Jason T Manka

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Europe PubMed Central

29 July 2017

2

object named as

Chrysa Malosh

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29 July 2017

21

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Carrie K Jones

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29 July 2017

author name string

Jon Jacobs

3

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29 July 2017

Paige N Vinson

6

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29 July 2017

Satyawan Jadhav

7

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29 July 2017

Elizabeth J Herman

8

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29 July 2017

M Luz Martín-Martín

13

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29 July 2017

Han Min Tong

14

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29 July 2017

Silvia López

15

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29 July 2017

Gregor J MacDonald

16

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29 July 2017

J Scott Daniels

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29 July 2017

C David Weaver

19

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29 July 2017

language of work or name

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publication date

25 June 2014

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29 July 2017

Journal of Medicinal Chemistry

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Europe PubMed Central

29 July 2017

57

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29 July 2017

13

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29 July 2017

5620-5637

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Europe PubMed Central

29 July 2017

Metabotropic glutamate receptor 5-positive allosteric modulators for the treatment of schizophrenia (2004-2012).

1 reference

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5 July 2018

Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096224

5 July 2018

Dihydrothiazolopyridone derivatives as a novel family of positive allosteric modulators of the metabotropic glutamate 5 (mGlu5) receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096224

5 July 2018

Biotransformation of a novel positive allosteric modulator of metabotropic glutamate receptor subtype 5 contributes to seizure-like adverse events in rats involving a receptor agonism-dependent mechanism

1 reference

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5 July 2018

A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096224

5 July 2018

Discovery of N-Aryl Piperazines as Selective mGlu(5) Potentiators with Efficacy in a Rodent Model Predictive of Anti-Psychotic Activity

1 reference

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5 July 2018

Discovery and SAR of a novel series of non-MPEP site mGlu₅ PAMs based on an aryl glycine sulfonamide scaffold

1 reference

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5 July 2018

Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity

1 reference

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5 July 2018

Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover

1 reference

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5 July 2018

In vitro characterisation of the novel positive allosteric modulators of the mGlu₅ receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat.

1 reference

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5 July 2018

Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096224

5 July 2018

Progress toward positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).

1 reference

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5 July 2018

Selective remediation of reversal learning deficits in the neurodevelopmental MAM model of schizophrenia by a novel mGlu5 positive allosteric modulator

1 reference

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5 July 2018

Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function.

1 reference

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5 July 2018

"Molecular switches" on mGluR allosteric ligands that modulate modes of pharmacology

1 reference

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5 July 2018

Preclinical profile of a novel metabotropic glutamate receptor 5 positive allosteric modulator

1 reference

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5 July 2018

Synthesis and SAR of centrally active mGlu5 positive allosteric modulators based on an aryl acetylenic bicyclic lactam scaffold

1 reference

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5 July 2018

Discovery of novel positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096224

5 July 2018

Discovery of molecular switches within the ADX-47273 mGlu5 PAM scaffold that modulate modes of pharmacology to afford potent mGlu5 NAMs, PAMs and partial antagonists

1 reference

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5 July 2018

4-aryl piperazine and piperidine amides as novel mGluR5 positive allosteric modulators

1 reference

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5 July 2018

Discovery of a Novel Chemical Class of mGlu(5) Allosteric Ligands with Distinct Modes of Pharmacology

1 reference

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5 July 2018

Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity

1 reference

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5 July 2018

Discovery of molecular switches that modulate modes of metabotropic glutamate receptor subtype 5 (mGlu5) pharmacology in vitro and in vivo within a series of functionalized, regioisomeric 2- and 5-(phenylethynyl)pyrimidines

1 reference

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5 July 2018

Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273

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5 July 2018

Atypical antipsychotic drugs and the risk of sudden cardiac death

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5 July 2018

Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia

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5 July 2018

ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activiti

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Direct interaction enables cross-talk between ionotropic and group I metabotropic glutamate receptors

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A novel assay of Gi/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the pharmacology of the group III metabotropic glutamate receptors

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5 July 2018

Dopamine hypothesis of schizophrenia: making sense of it all.

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5 July 2018

Challenges in the development of mGluR5 positive allosteric modulators: the discovery of CPPHA.

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5 July 2018

Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes

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Discovery of positive allosteric modulators of metabotropic glutamate receptor subtype 5 (mGluR5).

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Identification of separable cognitive factors in schizophrenia

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Virtual screening in lead discovery and optimization.

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of schizophrenia and spectrum disorders: pharmacotherapy, psychosocial treatments, and neurotransmitter interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/24914612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The thermodynamic basis for the use of lipophilic efficiency (LipE) in enthalpic optimizations

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM500259Z

1 reference

Europe PubMed Central

29 July 2017

1 reference

Europe PubMed Central

29 July 2017

1 reference

Europe PubMed Central

29 July 2017

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