(Q33910221)

30 July 2017

title

Cooperativity of oncogenic K-ras and downregulated p16/INK4A in human pancreatic tumorigenesis (English)

1 reference

30 July 2017

6

Huamin Wang

1 reference

30 July 2017

7

Jason B Fleming

1 reference

30 July 2017

Zhe Chang

1

1 reference

30 July 2017

Huaiqiang Ju

2

1 reference

30 July 2017

Jianhua Ling

3

1 reference

30 July 2017

Zhuonan Zhuang

4

1 reference

30 July 2017

Zhongkui Li

5

1 reference

30 July 2017

James W Freeman

8

1 reference

30 July 2017

Dihua Yu

9

1 reference

30 July 2017

Peng Huang

10

1 reference

30 July 2017

Paul J Chiao

11

1 reference

30 July 2017

language of work or name

English

0 references

publication date

16 July 2014

1 reference

30 July 2017

1 reference

30 July 2017

volume

9

1 reference

30 July 2017

issue

7

1 reference

30 July 2017

page(s)

e101452

1 reference

Creative Commons Attribution 4.0 International

30 July 2017

copyright license

start time

16 July 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Loss of canonical Smad4 signaling promotes KRAS driven malignant transformation of human pancreatic duct epithelial cells and metastasis

5 July 2018

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Oncogenic K-Ras and loss of Smad4 mediate invasion by activating an EGFR/NF-κB Axis that induces expression of MMP9 and uPA in human pancreas progenitor cells

5 July 2018

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Knockdown of RON receptor kinase delays but does not prevent tumor progression while enhancing HGF/MET signaling in pancreatic cancer cell lines

5 July 2018

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Deciphering the mechanisms of tumorigenesis in human pancreatic ductal epithelial cells

5 July 2018

1 reference

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EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100754

EGF receptor is required for KRAS-induced pancreatic tumorigenesis

5 July 2018

1 reference

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Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases

5 July 2018

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The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells

5 July 2018

1 reference

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5 July 2018

Cancer statistics, 2010

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Expression of oncogenic K-ras and loss of Smad4 cooperate to induce the expression of EGFR and to promote invasion of immortalized human pancreas ductal cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100754

Ras activity levels control the development of pancreatic diseases.

5 July 2018

1 reference

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5 July 2018

1 reference

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K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling

5 July 2018

1 reference

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The HBP1 transcriptional repressor participates in RAS-induced premature senescence

5 July 2018

1 reference

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Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse

5 July 2018

1 reference

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Creating oral squamous cancer cells: a cellular model of oral-esophageal carcinogenesis

5 July 2018

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In vitro modeling of human pancreatic duct epithelial cell transformation defines gene expression changes induced by K-ras oncogenic activation in pancreatic carcinogenesis

5 July 2018

1 reference

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Use of human tissue to assess the oncogenic activity of melanoma-associated mutations

5 July 2018

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The HBP1 transcriptional repressor and the p38 MAP kinase: unlikely partners in G1 regulation and tumor suppression.

5 July 2018

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5 July 2018

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Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

5 July 2018

1 reference

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The Transcriptional Repressor HBP1 Is a Target of the p38 Mitogen-Activated Protein Kinase Pathway in Cell Cycle Regulation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100754

Immortalization with telomerase of the Nestin-positive cells of the human pancreas

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100754

Modelling the molecular circuitry of cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100754

Enumeration of the simian virus 40 early region elements necessary for human cell transformation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100754

Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100754

Creation of human tumour cells with defined genetic elements

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100754

Comparative phenotypic studies of duct epithelial cell lines derived from normal human pancreas and pancreatic carcinoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100754

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100754

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100754

Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100754

Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100754

Establishment of propagable epithelial cell lines from normal adult rat pancreas

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4100754

Keratinocyte Growth Factor/Fibroblast Growth Factor-7-regulated Cell Migration and Invasion through Activation of NF-κB Transcription Factors

5 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0101452

CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0101452

The tumor-suppressive functions of the human INK4A locus

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0101452

Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25029561

12 December 2020

inferred from PubMed ID database lookup

Hypermethylation of multiple genes in pancreatic adenocarcinoma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25029561

12 December 2020

inferred from PubMed ID database lookup

Opinion: Comparative biology of mouse versus human cells: modelling human cancer in mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25029561

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1371/JOURNAL.PONE.0101452

1 reference

release_iadhutoatfcarf7oze7ddhlu2i

30 July 2017

0 references

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/iadhutoatfcarf7oze7ddhlu2i

24 November 2022

mapped directly with Wikidata item

PMC publication ID

4100754

1 reference

30 July 2017

1 reference