(Q33933498)

English

Development and optimization of anti-HIV nucleoside analogs and prodrugs: A review of their cellular pharmacology, structure-activity relationships and pharmacokinetics

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scholarly article

1 reference

Europe PubMed Central

30 July 2017

Development and optimization of anti-HIV nucleoside analogs and prodrugs: A review of their cellular pharmacology, structure-activity relationships and pharmacokinetics (English)

1 reference

Europe PubMed Central

30 July 2017

1 reference

based on heuristic

inferred from title

pharmacokinetics

1 reference

based on heuristic

inferred from title

author name string

Tan X

1

1 reference

Europe PubMed Central

30 July 2017

Chu CK

2

1 reference

Europe PubMed Central

30 July 2017

Boudinot FD

3

1 reference

Europe PubMed Central

30 July 2017

language of work or name

0 references

publication date

1 October 1999

1 reference

Europe PubMed Central

30 July 2017

Advanced Drug Delivery Reviews

1 reference

Europe PubMed Central

30 July 2017

39

1 reference

Europe PubMed Central

30 July 2017

1-3

1 reference

Europe PubMed Central

30 July 2017

117-151

1 reference

Europe PubMed Central

30 July 2017

HIV inhibitors targeted at the reverse transcriptase

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The in vitro and in vivo anti-retrovirus activity, and intracellular metabolism of 3'-azido-2',3'-dideoxythymidine and 2',3'-dideoxycytidine are highly dependent on the cell species

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Comparative analysis of anti-human immunodeficiency virus type 1 activities of dideoxynucleoside analogs in resting and activated peripheral blood mononuclear cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

In vitro bone marrow toxicity of nucleoside analogs against human immunodeficiency virus

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

In vitro potency of inhibition by antiviral drugs of hematopoietic progenitor colony formation correlates with exposure at hemotoxic levels in human immunodeficiency virus-positive humans.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of 2',3'-dideoxynucleosides on proliferation and differentiation of human pluripotent progenitors in liquid culture and their effects on mitochondrial DNA synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Nucleoside and nucleobase transport in animal cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Membrane permeation mechanisms of 2',3'-dideoxynucleosides

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2',3'-dideoxynucleosides

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Anti-retrovirus activity of 3'-fluoro- and 3'-azido-substituted pyrimidine 2',3'-dideoxynucleoside analogues

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis and anti-HIV-1 activity of 2'-"up"-fluoro analogs of active anti-AIDS nucleosides 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (DDC)

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Fluorinated sugar analogues of potential anti-HIV-1 nucleosides

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

2'-azido-2',3'-dideoxypyrimidine nucleosides. Synthesis and antiviral activity against human immunodeficiency virus

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis and antiretrovirus properties of 5'-isocyano-5'-deoxythymidine, 5'-isocyano-2',5'-dideoxyuridine, 3'-azido-5'-isocyano-3',5'-dideoxythymidine, and 3'-azido-5'-isocyano-2',3',5'-trideoxyuridine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

5'-O-phosphonomethyl-2',3'-dideoxynucleosides: synthesis and anti-HIV activity

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis, in vitro biological stability, and anti-HIV activity of 5-halo-6-alkoxy(or azido)-5,6-dihydro-3'-azido-3'-deoxythymidine diastereomers as potential prodrugs to 3'-azido-3'-deoxythymidine (AZT).

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis and antiviral (HIV-1, HBV) activities of 5-halo-6-methoxy(or azido)-5,6-dihydro-3'-fluoro-3'-deoxythymidine diastereomers. Potential prodrugs to 3'-fluoro-3'-deoxythymidine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis of the 2-chloro analogues of 3'-deoxyadenosine, 2',3'-dideoxyadenosine, and 2',3'-didehydro-2',3'-dideoxyadenosine as potential antiviral agents

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

3'-Fluoro-2',3'-dideoxy-5-chlorouridine: most selective anti-HIV-1 agent among a series of new 2'- and 3'-fluorinated 2',3'-dideoxynucleoside analogues

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

5-Chloro-substituted derivatives of 2', 3'-didehydro-2',3'-dideoxyuridine, 3'-fluoro-2',3'-dideoxyuridine and 3'-azido-2',3'-dideoxyuridine as anti-HIV agents

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis and anti-HIV evaluation of 2',3'-dideoxyribo-5-chloropyrimidine analogues: reduced toxicity of 5-chlorinated 2',3'-dideoxynucleosides

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Lipophilic halogenated congeners of 2',3'-dideoxypurine nucleosides active against human immunodeficiency virus in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis and biological evaluation of 2',3'-dideoxy-L-pyrimidine nucleosides as potential antiviral agents against human immunodeficiency virus (HIV) and hepatitis B virus (HBV).

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Design and synthesis of 2',3'-dideoxy-2',3'-didehydro-beta-L-cytidine (beta-L-d4C) and 2',3'-dideoxy 2',3'-didehydro-beta-L-5-fluorocytidine (beta-L-Fd4C), two exceptionally potent inhibitors of human hepatitis B virus (HBV) and potent inhibitors of

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis and anti-HIV activity of isonucleosides

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of human immunodeficiency virus (HIV-1/HTLV-IIIBa-L) replication in fresh and cultured human peripheral blood monocytes/macrophages by azidothymidine and related 2',3'-dideoxynucleosides

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

3'-Azido-3'-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

3'-azido-3'-deoxythymidine (AZT) monophosphate: an inhibitor of exonucleolytic repair of AZT-terminated DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of mammalian DNA polymerase-associated 3' to 5' exonuclease activity by 5'-monophosphates of 3'-azido-3'-deoxythymidine and 3'-amino-3'-deoxythymidine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

3'-Azidothymidine (zidovudine) inhibits glycosylation and dramatically alters glycosphingolipid synthesis in whole cells at clinically relevant concentrations

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Enhanced in vitro inhibition of HIV-1 replication by 3'-fluoro-3'-deoxythymidine compared to several other nucleoside analogs

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of HIV-associated reverse transcriptase by sugar-modified derivatives of thymidine 5'-triphosphate in comparison to cellular DNA polymerases alpha and beta

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation, anti-HIV activity and cytotoxicity of 3'-fluorothymidine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Comparison of in vitro biological properties and mouse toxicities of three thymidine analogs active against human immunodeficiency virus

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Comparisons of anti-human immunodeficiency virus activities, cellular transport, and plasma and intracellular pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-azido-3'-deoxythymidine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Potent and selective in vitro activity of 3'-deoxythymidin-2'-ene (3'-deoxy-2',3'-didehydrothymidine) against human immunodeficiency virus

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Both 2',3'-dideoxythymidine and its 2',3'-unsaturated derivative (2',3'-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibitory effect of 2',3'-didehydro-2',3'-dideoxynucleosides on infectivity, cytopathic effects, and replication of human immunodeficiency virus

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Cellular pharmacology of 2',3'-dideoxy-2',3'-didehydrothymidine, a nucleoside analog active against human immunodeficiency virus

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine. A highly potent and selective anti-HIV agent

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Clinical pharmacokinetics of zidovudine. An overview of current data

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Zidovudine. An update of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Plasma and cerebrospinal fluid pharmacokinetics of 3'-azido-3'-deoxythymidine: a novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Clinical pharmacokinetics of 3'-azido-3'-deoxythymidine (zidovudine) and catabolites with formation of a toxic catabolite, 3'-amino-3'-deoxythymidine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-deoxy-2',3'-didehydrothymidine in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-deoxy-2',3'-didehydrothymidine in rhesus monkeys

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Stavudine: a review of its pharmacodynamic and pharmacokinetic properties and clinical potential in HIV infection

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Clinical pharmacokinetics of stavudine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmacokinetics of stavudine in patients with AIDS or AIDS-related complex

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

2',3'-didehydro-3'-deoxythymidine (d4T) in patients with AIDS or AIDS-related complex: a phase I trial

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of 3'-azido-2',3'-dideoxyuridine and preferential inhibition of human and simian immunodeficiency virus reverse transcriptases by its 5'-triphosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Insights into HIV chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

5-Chloro-2',3'-dideoxy-3'-fluorouridine (935U83), a selective anti-human immunodeficiency virus agent with an improved metabolic and toxicological profile

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

3'-Azido-2',3'-dideoxyuridine (AzddU): comparative pharmacokinetics with 3'-azido-3'-deoxythymidine (AZT) in monkeys

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Initial studies on the cellular pharmacology of 2',3-dideoxycytidine, an inhibitor of HTLV-III infectivity.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Ultrastructural changes associated with reduced mitochondrial DNA and impaired mitochondrial function in the presence of 2'3'-dideoxycytidine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Antiviral activity of 2',3'-dideoxy-beta-L-5-fluorocytidine (beta-L-FddC) and 2',3'-dideoxy-beta-L-cytidine (beta-L-ddC) against hepatitis B virus and human immunodeficiency virus type 1 in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Anti-human immunodeficiency virus activities of the beta-L enantiomer of 2',3'-dideoxycytidine and its 5-fluoro derivative in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of human immunodeficiency virus type 1 reverse transcriptase by the 5'-triphosphate beta enantiomers of cytidine analogs

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

L- and D-enantiomers of 2',3'-dideoxycytidine 5'-triphosphate analogs as substrates for human DNA polymerases. Implications for the mechanism of toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Favorable interaction of beta-L(-) nucleoside analogues with clinically approved anti-HIV nucleoside analogues for the treatment of human immunodeficiency virus

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Zalcitabine. Clinical pharmacokinetics and efficacy.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Zalcitabine. An update of its pharmacodynamic and pharmacokinetic properties and clinical efficacy in the management of HIV infection

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmacokinetics of 2',3'-dideoxycytidine in patients with AIDS and related disorders.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Phase I studies of 2',3'-dideoxycytidine in severe human immunodeficiency virus infection as a single agent and alternating with zidovudine (AZT).

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Initial studies on the cellular pharmacology of 2',3'-dideoxyinosine, an inhibitor of HIV infectivity

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Metabolism of 2',3'-dideoxyinosine (ddI) in human blood

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Acid-stable 2'-fluoro purine dideoxynucleosides as active agents against HIV

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Antiviral, metabolic, and pharmacokinetic properties of the isomeric dideoxynucleoside 4(S)-(6-amino-9H-purin-9-yl)tetrahydro-2(S)-furanmethanol

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmacokinetics of 2',3'-dideoxyadenosine and 2',3'-dideoxyinosine in patients with severe human immunodeficiency virus infection

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Didanosine. An update on its antiviral activity, pharmacokinetic properties and therapeutic efficacy in the management of HIV disease

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Food-induced reduction in bioavailability of didanosine.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmacokinetics of didanosine in patients with acquired immunodeficiency syndrome or acquired immunodeficiency syndrome-related complex.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Overview of phase I trials of 2',3'-dideoxyinosine (ddI) conducted on adult patients

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The National Cancer Institute phase I study of 2',3'-dideoxyinosine administration in adults with AIDS or AIDS-related complex: analysis of activity and toxicity profiles

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of brain tissue localized purine metabolizing enzymes in the central nervous system delivery of anti-HIV agents 2'-beta-fluoro-2',3'-dideoxyinosine and 2'-beta-fluoro-2',3'-dideoxyadenosine in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Enhanced brain delivery of an anti-HIV nucleoside 2'-F-ara-ddI by xanthine oxidase mediated biotransformation

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

In vitro and in vivo evaluation of 6-azido-2',3'-dideoxy-2'-fluoro-beta-D-arabinofuranosylpurine and N6-methyl-2',3'-dideoxy-2'-fluoro-beta-D-arabinofuranosyladenine as prodrugs of the anti-HIV nucleosides 2'-F-ara-ddA and 2'-F-ara-ddI.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Central nervous system targeting of 2',3'-dideoxyinosine via adenosine deaminase-activated 6-halo-dideoxypurine prodrugs

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Activities of the four optical isomers of 2',3'-dideoxy-3'-thiacytidine (BCH-189) against human immunodeficiency virus type 1 in human lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Selective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Anti-human immunodeficiency virus type 1 activity and in vitro toxicity of 2'-deoxy-3'-thiacytidine (BCH-189), a novel heterocyclic nucleoside analog

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The separated enantiomers of 2'-deoxy-3'-thiacytidine (BCH 189) both inhibit human immunodeficiency virus replication in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

(-)-2'-deoxy-3'-thiacytidine is a potent, highly selective inhibitor of human immunodeficiency virus type 1 and type 2 replication in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Cellular metabolism of (−) enantiomeric 2′-deoxy-3′-thiacytidine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The intracellular phosphorylation of (-)-2'-deoxy-3'-thiacytidine (3TC) and the incorporation of 3TC 5'-monophosphate into DNA by HIV-1 reverse transcriptase and human DNA polymerase gamma

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Lamivudine (3TC) phosphorylation and drug interactions in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Lamivudine. A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in the management of HIV infection

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Evaluation of safety and efficacy of 3TC (lamivudine) in patients with asymptomatic or mildly symptomatic human immunodeficiency virus infection: a phase I/II study

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

A phase I/II study of 2'-deoxy-3'-thiacytidine (lamivudine) in patients with advanced human immunodeficiency virus infection

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmacokinetics and metabolism of racemic 2',3'-dideoxy-5-fluoro-3'-thiacytidine in rhesus monkeys

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Asymmetric synthesis of 1,3-dioxolane-pyrimidine nucleosides and their anti-HIV activity

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

L-beta-(2S,4S)- and L-alpha-(2S,4R)-dioxolanyl nucleosides as potential anti-HIV agents: asymmetric synthesis and structure-activity relationships

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

1,3-dioxolanylpurine nucleosides (2R,4R) and (2R,4S) with selective anti-HIV-1 activity in human lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Pure nucleoside enantiomers of beta-2',3'-dideoxycytidine analogs are selective inhibitors of hepatitis B virus in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmacokinetics of (-)-beta-D-2-aminopurine dioxolane and (-)-beta-D-2-amino-6-chloropurine dioxolane and their antiviral metabolite (-)-beta-D-dioxolane guanine in rhesus monkeys

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Biotransformation and pharmacokinetics of prodrug 9-(beta-D-1,3-dioxolan-4-yl)-2-aminopurine and its antiviral metabolite 9-(beta-D-1,3-dioxolan-4-yl)guanine in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Studies on the biochemical basis for the antiviral activities of some nucleoside analogs

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Potent and selective activity of a new carbocyclic nucleoside analog (carbovir: NSC 614846) against human immunodeficiency virus in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis and anti-HIV activity of carbocyclic 2',3'-didehydro-2',3'-dideoxy 2,6-disubstituted purine nucleosides

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Metabolism of the carbocyclic nucleoside analogue carbovir, an inhibitor of human immunodeficiency virus, in human lymphoid cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Comparison of the effect of Carbovir, AZT, and dideoxynucleoside triphosphates on the activity of human immunodeficiency virus reverse transcriptase and selected human polymerases

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Activities of (-)-carbovir and 3'-azido-3'-deoxythymidine against human immunodeficiency virus in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Metabolism of carbovir, a potent inhibitor of human immunodeficiency virus type 1, and its effects on cellular metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Lack of mitochondrial toxicity in CEM cells treated with carbovir

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Unique intracellular activation of the potent anti-human immunodeficiency virus agent 1592U89

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmacokinetics and bioavailability of carbovir, a carbocyclic nucleoside active against human immunodeficiency virus, in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Comparative brain exposure to (-)-carbovir after (-)-carbovir or (-)-6-aminocarbovir intravenous infusion in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

9-[(2RS)-3-fluoro-2-phosphonylmethoxypropyl] derivatives of purines: a class of highly selective antiretroviral agents in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Activity of the (R)-enantiomers of 9-(2-phosphonylmethoxypropyl)-adenine and 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine against human immunodeficiency virus in different human cell systems

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Potent and selective inhibition of human immunodeficiency virus type 1 (HIV-1) by 5-ethyl-6-phenylthiouracil derivatives through their interaction with the HIV-1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Activity of acyclic 6-(phenylselenenyl)pyrimidine nucleosides against human immunodeficiency viruses in primary lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Specific anti-HIV-1 "acyclonucleosides" which cannot be phosphorylated: synthesis of some deoxy analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis and antiviral activity of deoxy analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Susceptibility of human immunodeficiency virus type 1 replication in vitro to acyclic adenosine analogs and synergy of the analogs with 3'-azido-3'-deoxythymidine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Cellular uptake of phosphonylmethoxyalkylpurine derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of 9-(2-phosphonomethoxyethyl)adenine and 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine by AMP(dAMP) kinase from L1210 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Activity of acyclic nucleoside phosphonate analogues against human immunodeficiency virus in monocyte/macrophages and peripheral blood lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

9-(2-Phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Prodrugs of 2',3'-didehydro-3'-deoxythymidine (D4T): synthesis, antiviral activity, and rapid pharmacokinetic evaluation

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Cytidine diphosphate diglyceride analogs of antiretroviral dideoxynucleosides: evidence for release of dideoxynucleoside-monophosphates by phospholipid biosynthetic enzymes in rat liver subcellular fractions

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Lipid conjugates of antiretroviral agents: release of antiretroviral nucleoside monophosphates by a nucleoside diphosphate diglyceride hydrolase activity from rat liver mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Greatly enhanced inhibition of human immunodeficiency virus type 1 replication in CEM and HT4-6C cells by 3'-deoxythymidine diphosphate dimyristoylglycerol, a lipid prodrug of 3'-deoxythymidine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphatidylazidothymidine and phosphatidyl-ddC: assessment of uptake in mouse lymphoid tissues and antiviral activities in human immunodeficiency virus-infected cells and in Rauscher leukemia virus-infected mice

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Lymphatic targeting of anti-HIV nucleosides: distribution of 2',3'-dideoxyinosine after intravenous and oral administration of dipalmitoylphosphatidyl prodrug in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

AIDS dementia: synthesis and properties of a derivative of 3'-azido-3'-deoxythymidine (AZT) that may become 'locked' in the central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

A pro-drug of zidovudine with enhanced efficacy against human immunodeficiency virus

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Brain targeting of anti-HIV nucleosides: synthesis and in vitro and in vivo studies of dihydropyridine derivatives of 3'-azido-2',3'-dideoxyuridine and 3'-azido-3'-deoxythymidine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

A dihydropyridine carrier system for sustained delivery of 2',3'-dideoxynucleosides to the brain

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis and pharmacokinetics of a dihydropyridine chemical delivery system for the antiimmunodeficiency virus agent dideoxycytidine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis, oral bioavailability determination, and in vitro evaluation of prodrugs of the antiviral agent 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA).

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Metabolism and in vitro antiretroviral activities of bis(pivaloyloxymethyl) prodrugs of acyclic nucleoside phosphonates

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis and anti-HIV evaluation of some phosphoramidate derivatives of AZT: studies on the effect of chain elongation on biological activity

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis and anti-HIV activity of some haloalkyl phosphoramidate derivatives of 3'-azido-3'-deoxythymidine (AZT): potent activity of the trichloroethyl methoxyalaninyl compound

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Aryl phosphate derivatives of AZT retain activity against HIV1 in cell lines which are resistant to the action of AZT

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphoramidate derivatives of d4T as inhibitors of HIV: the effect of amino acid variation.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Intracellular delivery of bioactive AZT nucleotides by aryl phosphate derivatives of AZT.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Anti-HIV and anti-HBV activity and resistance profile of 2',3'-dideoxy-3'-thiacytidine (3TC) and its arylphosphoramidate derivative CF 1109.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphoramidate derivatives of d4T with improved anti-HIV efficacy retain full activity in thymidine kinase-deficient cells

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphoramidate derivatives of 2′,3′-didehydro-2′,3′-dideoxyadenosine [d4A] have markedly improved anti-HIV potency and selectivity

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Conversion of 2',3'-dideoxyadenosine (ddA) and 2',3'-didehydro-2',3'-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Intracellular delivery of nucleoside monophosphates through a reductase-mediated activation process

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Equal inhibition of the replication of human immunodeficiency virus in human T-cell culture by ddA bis(SATE)phosphotriester and 3'-azido-2',3'-dideoxythymidine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Decomposition pathways and in vitro HIV inhibitory effects of isoddA pronucleotides: toward a rational approach for intracellular delivery of nucleoside 5'-monophosphates

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Mononucleoside phosphotriester derivatives with S-acyl-2-thioethyl bioreversible phosphate-protecting groups: intracellular delivery of 3'-azido-2',3'-dideoxythymidine 5'-monophosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Anti-human immunodeficiency virus type 1 activities of dideoxynucleoside phosphotriester derivatives in primary monocytes/macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis, in vitro antiviral evaluation, and stability studies of bis(S-acyl-2-thioethyl) ester derivatives of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) as potential PMEA prodrugs with improved oral bioavailability

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanism of anti-HIV action of masked alaninyl d4T-MP derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Aryl phosphoramidate derivatives of d4T have improved anti-HIV efficacy in tissue culture and may act by the generation of a novel intracellular metabolite.

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Oral bioavailability of the antiretroviral agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) from three formulations of the prodrug bis(pivaloyloxymethyl)-PMEA in fasted male cynomolgus monkeys

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

In vivo Antiretroviral Efficacy of Oral bis(POM)-PMEA, the bis(Pivaloyloxymethyl)prodrug of 9-(2-Phosphonylmethoxyethyl) adenine (PMEA)

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Nucleotide dimers suppress HIV expression in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Activities of 3'-azido-3'-deoxythymidine nucleotide dimers in primary lymphocytes infected with human immunodeficiency virus type 1

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Targeting of antiviral drugs to T4-lymphocytes. Anti-HIV activity of neoglycoprotein-AZTMP conjugates in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Lipophilic glycosyl phosphotriester derivatives of AZT: synthesis, NMR transmembrane transport study, and antiviral activity

1 reference

https://api.crossref.org/works/10.1016%2FS0169-409X%2899%2900023-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0169-409X(99)00023-X

1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

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