(Q33939052)

30 July 2017

Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole (English)

1 reference

30 July 2017

1 reference

Jan Wildenhain

4

0 references

Gerard D. Wright

object named as

Gerard D Wright

11

0 references

Michaela Spitzer

object named as

Michaela Spitzer

1

0 references

author name string

Emma Griffiths

2

1 reference

30 July 2017

Kim M Blakely

3

1 reference

30 July 2017

Linda Ejim

5

1 reference

30 July 2017

Laura Rossi

6

1 reference

30 July 2017

Gianfranco De Pascale

7

1 reference

30 July 2017

Jasna Curak

8

1 reference

30 July 2017

Eric Brown

9

1 reference

30 July 2017

Mike Tyers

10

1 reference

30 July 2017

21 June 2011

1 reference

Molecular Systems Biology

30 July 2017

1 reference

30 July 2017

7

1 reference

30 July 2017

499

1 reference

Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action

30 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Azole drugs are imported by facilitated diffusion in Candida albicans and other pathogenic fungi

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Evolutionary divergence in the fungal response to fluconazole revealed by soft clustering

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Use of Antifungal Combination Therapy: Agents, Order, and Timing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

The antidepressant sertraline targets intracellular vesiculogenic membranes in yeast

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Protein dynamics in drug combinations: a linear superposition of individual-drug responses

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Mechanism of the synergistic effect of amiodarone and fluconazole in Candida albicans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Polymyxin B, in combination with fluconazole, exerts a potent fungicidal effect

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Genetic Basis of Antifungal Drug Resistance

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulence

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

The genetic landscape of a cell

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Chemogenomic profiling predicts antifungal synergies.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

A putative P-type ATPase, Apt1, is involved in stress tolerance and virulence in Cryptococcus neoformans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Invasive fungal infections: the challenge continues

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Candidemia on presentation to the hospital: development and validation of a risk score

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Proteomic analysis reveals a synergistic mechanism of fluconazole and berberine against fluconazole-resistant Candida albicans: endogenous ROS augmentation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Echinocandins: the newest class of antifungals

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Invasive fungal infections in the paediatric and neonatal population: diagnostics and management issues.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Synergistic drug combinations tend to improve therapeutically relevant selectivity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Efflux-mediated antifungal drug resistance.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Precise gene-dose alleles for chemical genetics

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Algorithmic guided screening of drug combinations of arbitrary size for activity against cancer cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Network pharmacology: the next paradigm in drug discovery

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Combination chemical genetics

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Models from experiments: combinatorial drug perturbations of cancer cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Off-target effects of psychoactive drugs revealed by genome-wide assays in yeast

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

The chemical genomic portrait of yeast: uncovering a phenotype for all genes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Systematic validation and atomic force microscopy of non-covalent short oligonucleotide barcode microarrays

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

The BioGRID Interaction Database: 2008 update

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

High-throughput screening for fatty acid uptake inhibitors in humanized yeast identifies atypical antipsychotic drugs that cause dyslipidemias

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Sex and virulence of human pathogenic fungi

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Chemical combination effects predict connectivity in biological systems

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

GOlorize: a Cytoscape plug-in for network visualization with Gene Ontology-based layout and coloring

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

The host acts as a genetic bottleneck during serial infections: an insect-fungal model system

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Galleria mellonella as a model system to study Cryptococcus neoformans pathogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Systematic interpretation of genetic interactions using protein networks

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Multicomponent therapeutics for networked systems

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

From large networks to small molecules

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Recent trends in the epidemiology of invasive mycoses

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Systematic discovery of multicomponent therapeutics

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Systematic genetic analysis with ordered arrays of yeast deletion mutants

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Developmental system drift and flexibility in evolutionary trajectories

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Genomic profiling of drug sensitivities via induced haploinsufficiency.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Nikkomycin Z is a specific inhibitor of Saccharomyces cerevisiae chitin synthase isozyme Chs3 in vitro and in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Biological membranes as bilayer couples. A molecular mechanism of drug-erythrocyte interactions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Characterization of enzymatic synthesis of sphingolipid long-chain bases in Saccharomyces cerevisiae: mutant strains exhibiting long-chain-base auxotrophy are deficient in serine palmitoyltransferase activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159983

Multiple weak hits confuse complex systems: a transcriptional regulatory network as an example.

5 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FMSB.2011.31

Invasive mold infections in allogeneic bone marrow transplant recipients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMSB.2011.31

Systems biology and combination therapy in the quest for clinical efficacy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMSB.2011.31

Emerging targets for the development of novel antifungal therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMSB.2011.31

A robustness-based approach to systems-oriented drug design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMSB.2011.31

Cloning and characterization of the lanosterol 14alpha-demethylase (ERG11) gene in Cryptococcus neoformans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMSB.2011.31

Functional classification of drugs by properties of their pairwise interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMSB.2011.31

Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMSB.2011.31

Genetic basis of individual differences in the response to small-molecule drugs in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMSB.2011.31

Identification of a novel inhibitor specific to the fungal chitin synthase. Inhibition of chitin synthase 1 arrests the cell growth, but inhibition of chitin synthase 1 and 2 is lethal in the pathogenic fungus Candida albicans

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21694716

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Trends in the postmortem epidemiology of invasive fungal infections at a university hospital

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21694716

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Synergy, antagonism, and what the chequerboard puts between them

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21694716

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/MSB.2011.31

1 reference

30 July 2017

1 reference

30 July 2017

1 reference