(Q33940458)

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The Gab1 docking protein links the b cell antigen receptor to the phosphatidylinositol 3-kinase/Akt signaling pathway and to the SHP2 tyrosine phosphatase.

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6 November 2019

The Gab1 docking protein links the b cell antigen receptor to the phosphatidylinositol 3-kinase/Akt signaling pathway and to the SHP2 tyrosine phosphatase (English)

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11278704%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

Michael R. Gold

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6 November 2019

author name string

Ingham RJ

1

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6 November 2019

Santos L

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6 November 2019

Dang-Lawson M

3

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6 November 2019

Holgado-Madruga M

4

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6 November 2019

Dudek P

5

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6 November 2019

Maroun CR

6

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6 November 2019

Wong AJ

7

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6 November 2019

Matsuuchi L

8

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6 November 2019

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22 January 2001

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6 November 2019

Journal of Biological Chemistry

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6 November 2019

276

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6 November 2019

12257-12265

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6 November 2019

15

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6 November 2019

The complexity of signaling pathways activated by the BCR.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Molecular mechanisms in B cell antigen receptor signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Positive versus negative signaling by lymphocyte antigen receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Signal transduction from the B cell antigen-receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

SH2 domains recognize specific phosphopeptide sequences

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Initiation and processing of signals from the B cell antigen receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Regulation of B cell function by linker proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Adapter proteins in lymphocyte antigen-receptor signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Signal-dependent membrane targeting by pleckstrin homology (PH) domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

The dynamics of protein kinase B regulation during B cell antigen receptor engagement

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Akt activation by growth factors is a multiple-step process: the role of the PH domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

SHIP modulates immune receptor responses by regulating membrane association of Btk.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Oct-1 protein promotes functional transcription complex assembly on the mouse mammary tumor virus promoter

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

The Gab1 protein is a docking site for multiple proteins involved in signaling by the B cell antigen receptor.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

The IRS-signalling system during insulin and cytokine action

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Determination of Gab1 (Grb2-associated binder-1) interaction with insulin receptor-signaling molecules

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Production of high-titer helper-free retroviruses by transient transfection

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Rapid and efficient retrovirus-mediated gene transfer into B cell lines

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Constitutive and basal secretion from the endocrine cell line, AtT-20

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

The membrane IgM-associated proteins MB-1 and Ig-beta are sufficient to promote surface expression of a partially functional B-cell antigen receptor in a nonlymphoid cell line

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Engagement of Gab1 and Gab2 in erythropoietin signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

B cell antigen receptor-induced activation of Akt promotes B cell survival and is dependent on Syk kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

The phosphotyrosine phosphatase SHP-2 participates in a multimeric signaling complex and regulates T cell receptor (TCR) coupling to the Ras/mitogen-activated protein kinase (MAPK) pathway in Jurkat T cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

The COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Regulation of RasGRP via a phorbol ester-responsive C1 domain.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1 - Crk signaling complex formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

A conserved inositol phospholipid binding site within the pleckstrin homology domain of the Gab1 docking protein is required for epithelial morphogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Requirement of SHP2 binding to Grb2-associated binder-1 for mitogen-activated protein kinase activation in response to lysophosphatidic acid and epidermal growth factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010590200

21 January 2018

Identifiers

10.1074/JBC.M010590200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11278704%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11278704%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

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