(Q33941041)

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Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-β-dependent induction of pro-apoptotic Noxa.

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5 February 2020

Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-β-dependent induction of pro-apoptotic Noxa (English)

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5 February 2020

apoptotic process

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vaccinia virus

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Georg Gasteiger

4

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5 February 2020

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5 February 2020

Wolfgang Kastenmüller

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Wolfgang Kastenmüller

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5 February 2020

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Ingo Drexler

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5 February 2020

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Pedro Eitz Ferrer

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5 February 2020

Stephanie Potthoff

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5 February 2020

Susanne Kirschnek

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5 February 2020

Holger Ludwig

6

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5 February 2020

Stefan A Paschen

7

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5 February 2020

Andreas Villunger

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5 February 2020

Georg Häcker

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5 February 2020

publication date

16 June 2011

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5 February 2020

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5 February 2020

7

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5 February 2020

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5 February 2020

e1002083

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5 February 2020

copyright license

Creative Commons Attribution 4.0 International

16 June 2011

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April 2022 Public Data File from Crossref

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The BCL-2 family reunion

1 reference

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5 July 2018

Intracellular DNA recognition

1 reference

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5 July 2018

Vaccinia virus protein F1L is a caspase-9 inhibitor

1 reference

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5 July 2018

Proapoptotic signalling through Toll-like receptor-3 involves TRIF-dependent activation of caspase-8 and is under the control of inhibitor of apoptosis proteins in melanoma cells

1 reference

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5 July 2018

Vaccinia virus F1L interacts with Bak using highly divergent Bcl-2 homology domains and replaces the function of Mcl-1.

1 reference

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5 July 2018

Viral inhibitors reveal overlapping themes in regulation of cell death and innate immunity

1 reference

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5 July 2018

RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway

1 reference

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5 July 2018

Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells.

1 reference

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5 July 2018

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate

1 reference

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5 July 2018

Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome

1 reference

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5 July 2018

Endogenous Noxa Determines the Strong Proapoptotic Synergism of the BH3-Mimetic ABT-737 with Chemotherapeutic Agents in Human Melanoma Cells.

1 reference

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5 July 2018

Vaccinia-induced epidermal growth factor receptor-MEK signalling and the anti-apoptotic protein F1L synergize to suppress cell death during infection

1 reference

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5 July 2018

Vaccinia virus-mediated inhibition of type I interferon responses is a multifactorial process involving the soluble type I interferon receptor B18 and intracellular components

1 reference

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5 July 2018

Vaccinia Virus Proteins A52 and B14 Share a Bcl-2–Like Fold but Have Evolved to Inhibit NF-κB rather than Apoptosis

1 reference

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5 July 2018

Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116819

5 July 2018

Viral control of mitochondrial apoptosis

1 reference

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5 July 2018

MDA5/RIG-I and virus recognition.

1 reference

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5 July 2018

The BCL-2 protein family: opposing activities that mediate cell death

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5 July 2018

Cross-priming of cytotoxic T cells dictates antigen requisites for modified vaccinia virus Ankara vector vaccines.

1 reference

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5 July 2018

BimS-induced apoptosis requires mitochondrial localization but not interaction with anti-apoptotic Bcl-2 proteins

1 reference

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5 July 2018

Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak.

1 reference

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5 July 2018

A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak

1 reference

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5 July 2018

The vaccinia virus protein F1L interacts with Bim and inhibits activation of the pro-apoptotic protein Bax

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116819

5 July 2018

Differences and similarities in viral life cycle progression and host cell physiology after infection of human dendritic cells with modified vaccinia virus Ankara and vaccinia virus.

1 reference

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5 July 2018

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

1 reference

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5 July 2018

Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116819

5 July 2018

The multidomain proapoptotic molecules Bax and Bak are directly activated by heat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116819

5 July 2018

The vaccinia virus F1L protein interacts with the proapoptotic protein Bak and inhibits Bak activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116819

5 July 2018

The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.

1 reference

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5 July 2018

Inactivation of the viral interleukin 1beta receptor improves CD8+ T-cell memory responses elicited upon immunization with modified vaccinia virus Ankara

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116819

5 July 2018

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116819

5 July 2018

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

1 reference

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5 July 2018

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

1 reference

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5 July 2018

Construction and isolation of recombinant MVA.

1 reference

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5 July 2018

Vaccinia virus encodes a previously uncharacterized mitochondrial-associated inhibitor of apoptosis

1 reference

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5 July 2018

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

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5 July 2018

The biochemistry of apoptosis

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5 July 2018

Characterization of the vaccinia virus H3L envelope protein: topology and posttranslational membrane insertion via the C-terminal hydrophobic tail

1 reference

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5 July 2018

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

1 reference

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5 July 2018

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

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5 July 2018

Gene expression and cytopathic effect of vaccinia virus inactivated by psoralen and long-wave UV light

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5 July 2018

Prevention of apoptosis by a baculovirus gene during infection of insect cells

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5 July 2018

A poxvirus Bcl-2-like gene family involved in regulation of host immune response: sequence similarity and evolutionary history

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1002083

21 January 2018

Modified vaccinia virus Ankara protein F1L is a novel BH3-domain-binding protein and acts together with the early viral protein E3L to block virus-associated apoptosis

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1002083

21 January 2018

To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1002083

21 January 2018

Infection of human dendritic cells with recombinant vaccinia virus MVA reveals general persistence of viral early transcription but distinct maturation-dependent cytopathogenicity

1 reference

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21 January 2018

Double-stranded RNA-binding protein E3 controls translation of viral intermediate RNA, marking an essential step in the life cycle of modified vaccinia virus Ankara

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1002083

21 January 2018

Single-stranded RNA viruses inactivate the transcriptional activity of p53 but induce NOXA-dependent apoptosis via post-translational modifications of IRF-1, IRF-3 and CREB

1 reference

https://pubmed.ncbi.nlm.nih.gov/21698224

12 December 2020

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The role of IFN regulatory factor-3 in the cytotoxic activity of NS-9, a polyinosinic-polycytidylic acid/cationic liposome complex, against tumor cells

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12 December 2020

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10.1371/JOURNAL.PPAT.1002083

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5 February 2020

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Europe PubMed Central

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5 February 2020

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5 February 2020

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