(Q33942241)

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Heterologous expression of xenobiotic mammalian-metabolizing enzymes in mutagenicity tester bacteria: an update and practical considerations

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scholarly article

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Europe PubMed Central

PubMed publication ID

30 July 2017

1 reference

Europe PubMed Central

Heterologous expression of xenobiotic mammalian-metabolizing enzymes in mutagenicity tester bacteria: an update and practical considerations (English)

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Nico P Vermeulen

1 reference

ORCID Public Data File 2021

author name string

Kranendonk M

1

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Laires A

2

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Rueff J

3

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Estabrook WR

4

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Vermeulen NP

5

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

language of work or name

0 references

publication date

1 May 2000

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Critical Reviews in Toxicology

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

30

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

287-306

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Metabolic activation of carcinogens

1 reference

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21 January 2018

Searches for ultimate chemical carcinogens and their reactions with cellular macromolecules.

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21 January 2018

Recombinant DNA approaches for the development of metabolic systems used in in vitro toxicology

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21 January 2018

Development and validation of alternative metabolic systems for mutagenicity testing in short-term assays

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21 January 2018

DNA-expressed human cytochrome P450s: a new age of molecular toxicology and human risk assessment

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21 January 2018

New applications of bacterial systems to problems in toxicology.

1 reference

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21 January 2018

Cytochromes P450 expression systems

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21 January 2018

Development and behavior in bacteria

1 reference

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21 January 2018

Genetic analysis of lipopolysaccharide core biosynthesis by Escherichia coli K-12: insertion mutagenesis of the rfa locus

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Role of the rfaG and rfaP genes in determining the lipopolysaccharide core structure and cell surface properties of Escherichia coli K-12

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The enhanced mutagenic potential of the MucAB proteins correlates with the highly efficient processing of the MucA protein

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Induction of -2 frameshift mutations within alternating GC sequences by carcinogens that bind to the C8 position of guanine residues: development of a specific mutation assay.

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Oxidative mutagens specific for A-T base pairs induce forward mutations to L-arabinose resistance in Salmonella typhimurium.

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Revised methods for the Salmonella mutagenicity test

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The SOS Chromotest, a colorimetric bacterial assay for genotoxins: procedures

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Evaluation of the new system (umu-test) for the detection of environmental mutagens and carcinogens

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Expression of human cytochrome P450 1A2 in Escherichia coli: a system for biotransformation and genotoxicity studies of chemical carcinogens.

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Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity

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Sulfotransferase-mediated activation of mutagens studied using heterologous expression systems.

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Comparisons of catalytic selectivity of cytochrome P450 subfamily enzymes from different species

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Genetically engineered cells stably expressing cytochrome P450 and their application to mutagen assays

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Drug metabolism by Escherichia coli expressing human cytochromes P450.

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Procarcinogen activation by cytochrome P450 3A4 and 3A5 expressed in Escherichia coli and by human liver microsomes.

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Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes

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A new Salmonella typhimurium NM5004 strain expressing rat glutathione S-transferase 5-5: use in detection of genotoxicity of dihaloalkanes using an SOS/umu test system.

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21 January 2018

Activation and inactivation of carcinogenic dihaloalkanes and other compounds by glutathione S-transferase 5-5 in Salmonella typhimurium tester strain NM5004.

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Enhancement of Bacterial Mutagenicity of Bifunctional Alkylating Agents by Expression of Mammalian Glutathione S-Transferase

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21 January 2018

Human glutathione S-transferase-expressing Salmonella typhimurium tester strains to study the activation/detoxification of mutagenic compounds: studies with halogenated compounds, aromatic amines and aflatoxin B1.

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Increased mutagenicity of 1,2-dibromo-3-chloropropane and tris(2,3-dibromopropyl)phosphate in Salmonella TA100 expressing human glutathione S-transferases

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N-acetyltransferase

1 reference

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Metabolic activation of N-hydroxylated metabolites of carcinogenic and mutagenic arylamines and arylamides by esterification

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New tester strains of Salmonella typhimurium highly sensitive to mutagenic nitroarenes

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NADPH-flavodoxin reductase and flavodoxin from Escherichia coli: characteristics as a soluble microsomal P450 reductase.

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21 January 2018

Isolation and prevalidation of an Escherichia coli tester strain for the use in mechanistic and metabolic studies of genotoxins.

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21 January 2018

MX100, a new Escherichia coli tester strain for use in genotoxicity studies.

1 reference

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Sulfonation in chemical carcinogenesis--history and present status

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Sulfation of carcinogenic aromatic hydroxylamines and hydroxamic acids by rat and human sulfotransferases: substrate specificity, developmental aspects and sex differences.

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21 January 2018

Sulfation of aromatic hydroxamic acids and hydroxylamines by multiple forms of human liver sulfotransferases.

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Discontinuity of homology of Escherichia coli and Salmonella typhimurium DNA in the lac region

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Maximizing expression of eukaryotic cytochrome P450s in Escherichia coli

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A general strategy for the expression of recombinant human cytochrome P450s in Escherichia coli using bacterial signal peptides: expression of CYP3A4, CYP2A6, and CYP2E1.

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Mutagenic DNA repair in enterobacteria

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Routes to active proteins from transformed microorganisms

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Complementation of a pKM101 derivative that decreases resistance to UV killing but increases susceptibility to mutagenesis.

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Regulation of ribosomal RNA promoters with a synthetic lac operator

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A review of the metabolism of xenobiotics by microorganisms with relation to short-term test systems for environmental carcinogens

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A sensitive method for the detection of mutagenic nitroarenes: construction of nitroreductase-overproducing derivatives of Salmonella typhimurium strains TA98 and TA100.

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Characterization of enzyme activities and cofactors involved in bioactivation and bioinactivation of chemical carcinogens in the tester strains Escherichia coli K12 MX100 and Salmonella typhimurium LT2 TA100.

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The role of acetylation in the mutagenicity of the antitumor agent, batracylin.

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Regulation of heme biosynthesis in Escherichia coli.

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Prochiral sulfoxidation as a probe for multiple forms of the microsomal flavin-containing monooxygenase: studies with rabbit FMO1, FMO2, FMO3, and FMO5 expressed in Escherichia coli.

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Characterization of flavin-containing monooxygenase 5 (FMO5) cloned from human and guinea pig: evidence that the unique catalytic properties of FMO5 are not confined to the rabbit ortholog

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Expression of rat liver NAD(P)H:quinone-acceptor oxidoreductase in Escherichia coli and mutagenesis in vitro at Arg-177

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Catalytic properties of NAD(P)H:quinone oxidoreductase-2 (NQO2), a dihydronicotinamide riboside dependent oxidoreductase

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Expression and role of the human liver UDP-glucuronosyltransferase UGT1*6 analyzed by specific antibodies raised against a hybrid protein produced in Escherichia coli.

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The Environmental Genome Project: functional analysis of polymorphisms

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Selection and characterization of human cytochrome P450 1A2 mutants with altered catalytic properties

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Molecular biological methods for characterizing drug-metabolizing enzymes in hepatic and extrahepatic tissues

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Identifiers

10.1080/10408440091159211

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

ResearchGate publication ID

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