(Q33538523)

English

Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity

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1 reference

Europe PubMed Central

27 July 2017

1 reference

Europe PubMed Central

Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity (English)

1 reference

Europe PubMed Central

27 July 2017

Nico P Vermeulen

1 reference

ORCID Public Data File 2021

author name string

Wormhoudt LW

1

1 reference

Europe PubMed Central

27 July 2017

Commandeur JN

2

1 reference

Europe PubMed Central

27 July 2017

Vermeulen NP

3

1 reference

Europe PubMed Central

27 July 2017

language of work or name

0 references

publication date

1 January 1999

1 reference

Europe PubMed Central

27 July 2017

Critical Reviews in Toxicology

1 reference

Europe PubMed Central

27 July 2017

29

1 reference

Europe PubMed Central

27 July 2017

59-124

1 reference

Europe PubMed Central

27 July 2017

1

1 reference

Europe PubMed Central

27 July 2017

Interindividual variability in catalytic activity and immunoreactivity of three major human liver cytochrome P450 isozymes.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Interindividual variability in metabolic activation in humans in vivo.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Genotoxic risk for humans due to work place exposure to ethylene oxide: remarkable individual differences in susceptibility.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Interindividual differences in the concentration of 1-hydroxypyrene-glucuronide in urine and polycyclic aromatic hydrocarbon-DNA adducts in peripheral white blood-cells after charbroiled beef consumption

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Genetically determined adverse drug reactions involving metabolism

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Clinical consequences of polymorphic drug oxidation

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Genetic and environmental factors causing variation in drug response

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Influence of pharmacogenetics on drug disposition and response

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Is environmental carcinogenesis modulated by host polymorphism?

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Role of genetics and drug metabolism in human cancer risk

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Metabolic polymorphisms in carcinogen metabolising enzymes and cancer susceptibility

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Diagnosis of polymorphisms in carcinogen-activating and inactivating enzymes and cancer susceptibility--a review

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Genetic metabolic polymorphisms and the risk of cancer: a review of the literature

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

The role of carcinogen-metabolizing enzyme polymorphisms in cancer susceptibility

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Combined effect of CYP1A1 inducibility and GSTM1 polymorphism on histological type of lung cancer.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

High susceptibility to lung cancer analyzed in terms of combined genotypes of P450IA1 and Mu-class glutathione S-transferase genes

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Analysis of mercapturic acids as a tool in biotransformation, biomonitoring and toxicological studies

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Mercapturic acids, protein adducts, and DNA adducts as biomarkers of electrophilic chemicals

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Future directions in the use of DNA adducts as internal dosimeters for monitoring human exposure to environmental mutagens and carcinogens

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Biochemical and molecular epidemiology of human cancer: indicators of carcinogen exposure, DNA damage, and genetic predisposition

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Markers of exposure to carcinogens

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Distribution of Ethylene Oxide in Human Blood and its Implications for Biomonitoring

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Comparison of 7-medG formation in white blood cells, liver and target organs in rats treated with methylating carcinogens.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Effect of route of administration of environmental methylating agents on 7-methylguanine formation in white blood cells and internal organs: implications for molecular epidemiology.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Relevance of urinary DNA adducts as markers of carcinogen exposure

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Molecular basis of polymorphic drug metabolism

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Human drug-metabolizing enzyme polymorphisms: effects on risk of toxicity and cancer

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Molecular mechanisms of genetic polymorphisms of drug metabolism

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Nomenclature for N-acetyltransferases

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

N-acetyltransferase

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Acetylation pharmacogenetics. The slow acetylator phenotype is caused by decreased or absent arylamine N-acetyltransferase in human liver

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Structure and restriction fragment length polymorphism of genes for human liver arylamine N-acetyltransferases

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Biochemical individuality and its implications for drug and carcinogen metabolism: recent insights from acetyltransferase and cytochrome P4501A2 phenotyping and genotyping in humans

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Partial purification and properties of the isoniazid transacetylase in human liver. Its relationship to the acetylation of p-aminosalicylic acid

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Metabolic activation of aromatic and heterocyclic N-hydroxyarylamines by wild-type and mutant recombinant human NAT1 and NAT2 acetyltransferases.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

N-and O-acetylation of aromatic and heterocyclic amine carcinogens by human monomorphic and polymorphic acetyltransferases expressed in COS-1 cells

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

The role of the human acetylation polymorphism in the metabolic activation of the food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Identification of a novel allele at the human NAT1 acetyltransferase locus

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Nucleotide sequence of an intronless gene for a human arylamine N-acetyltransferase related to polymorphic drug acetylation

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Molecular mechanism of slow acetylation of drugs and carcinogens in humans

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Diverse point mutations in the human gene for polymorphic N-acetyltransferase

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Determination of human NAT2 acetylator genotype by restriction fragment-length polymorphism and allele-specific amplification

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Preliminary phenotypic map of chromosome 4p16 based on 4p deletions.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Genetic basis for a lower prevalence of deficient CYP2D6 oxidative drug metabolism phenotypes in black Americans

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Polymorphism of glutathione S-transferase M1 and lung cancer risk among African-Americans and Caucasians in Los Angeles County, California.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Ethnic differences in the prevalence of the homozygous deleted genotype of glutathione S-transferase theta

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Molecular genetics of human polymorphic N-acetyltransferase: enzymatic analysis of 15 recombinant wild-type, mutant, and chimeric NAT2 allozymes.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Acetylator phenotyping of tuberculosis patients using matrix isoniazid or sulphadimidine and its prognostic significance for treatment with several intermittent isoniazid-containing regimens

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Acetylator phenotype and adverse effects of sulphasalazine in healthy subjects

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Adverse reactions during salicylazosulfapyridine therapy and the relation with drug metabolism and acetylator phenotype

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Antinuclear antibodies during procainamide treatment and drug acetylation.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Effect of acetylator phenotype on the rate at which procainamide induces antinuclear antibodies and the lupus syndrome

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Further investigations of the role of acetylation in sulphonamide hypersensitivity reactions

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

N-acetyltransferases: pharmacogenetics and clinical consequences of polymorphic drug metabolism

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

The impact of interindividual variation in NAT2 activity on benzidine urinary metabolites and urothelial DNA adducts in exposed workers

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

N-Acetyltransferase phenotypes in the urinary bladder carcinogenesis of a low-risk population.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Acetylator phenotype, aminobiphenyl-hemoglobin adduct levels, and bladder cancer risk in white, black, and Asian men in Los Angeles, California

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Slow N-acetylation genotype is a susceptibility factor in occupational and smoking related bladder cancer.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Metabolic polymorphisms affecting activation of toxic and mutagenic arylamines

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Interplay between heterocyclic amines in cooked meat and metabolic phenotype in the etiology of colon cancer

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Lack of association between the polyadenylation polymorphism in the NAT1 (acetyltransferase 1) gene and colorectal adenomas.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

The human hepatic cytochromes P450 involved in drug metabolism

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Oxygen and xenobiotic reductase activities of cytochrome P450.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Metabolic activation of carcinogens

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

P450 genes: structure, evolution, and regulation

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Molecular genetics of the P-450 superfamily

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

P450 and Human Cancer

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Modeling the active sites of cytochrome P450s and glutathione S-transferases, two of the most important biotransformation enzymes

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Assignment of the human 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 gene to chromosome 15

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Msp-1 polymorphism detected with a cDNA probe for the P-450 I family on chromosome 15.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

PstI polymorphism at the human P1450 gene on chromosome 15

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Genetic Linkage of Lung Cancer-Associated MspI Polymorphisms with Amino Acid Replacement in the Heme Binding Region of the Human Cytochrome P450IA1 Gene1

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Relationship between genotype and function of the human CYP1A1 gene

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Polymorphisms in the human CYP1A1 gene as susceptibility factors for lung cancer: exon-7 mutation (4889 A to G), and a T to C mutation in the 3'-flanking region.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

A novel CYP1A1 gene polymorphism in African-Americans.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Distribution of composite CYP1A1 genotypes in Africans, African-Americans and Caucasians

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Functional significance of different human CYP1A1 genotypes

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

The relationship between aryl hydrocarbon hydroxylase and polymorphisms of the CYP1A1 gene

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Polycyclic aromatic hydrocarbon-DNA adducts and the CYP1A1 restriction fragment length polymorphism

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Aromatic DNA adducts, micronuclei and genetic polymorphism for CYP1A1 and GST1 in chimney sweeps.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Expression and alternative splicing of the cytochrome P-450 CYP2A7

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Biochemistry and molecular biology of the human CYP2C subfamily

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

A 2.4-megabase physical map spanning the CYP2C gene cluster on chromosome 10q24

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

cDNA and amino acid sequences of two members of the human P450IIC gene subfamily

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Nucleotide sequence of a human liver cytochrome P-450 related to the rat male specific form

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

A screening test for slow metabolisers of tolbutamide

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Phenytoin: pharmacogenetic polymorphism of 4'-hydroxylation

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Phenytoin disposition and toxicity: role of pharmacogenetic and interethnic factors

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Relationship between mephenytoin, phenytoin and tolbutamide hydroxylations in healthy African subjects.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Site-directed mutation studies of human liver cytochrome P-450 isoenzymes in the CYP2C subfamily

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Allelic variants of human cytochrome P450 2C9: baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Genetic analysis of the cytochrome P-45OIIC18 (CYP2C18) gene and a novel member of the CYP2C subfamily.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Genetic polymorphism of S-mephenytoin hydroxylation

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Stereoselectivity of the arene epoxide pathway of mephenytoin hydroxylation in man.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

S-mephenytoin 4-hydroxylase is inherited as an autosomal-recessive trait in Japanese families

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Mephenytoin hydroxylation polymorphism: characterization of the enzymatic deficiency in liver microsomes of poor metabolizers phenotyped in vivo

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

High frequencies of CYP2C19 mutations and poor metabolism of proguanil in Vanuatu.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Importance of genetic factors in the regulation of diazepam metabolism: relationship to S-mephenytoin, but not debrisoquin, hydroxylation phenotype.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Factors influencing the metabolism of diazepam

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Steady-state plasma concentrations of imipramine and desipramine in relation to S-mephenytoin 4'-hydroxylation status in Japanese depressive patients

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Polymorphic metabolism of mephenytoin in man: pharmacokinetic interaction with a co-regulated substrate, mephobarbital

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Ethnic and genetic determinants of omeprazole disposition and effect.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

The activation of the biguanide antimalarial proguanil co-segregates with the mephenytoin oxidation polymorphism--a panel study

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Chloroguanide metabolism in relation to the efficacy in malaria prophylaxis and the S-mephenytoin oxidation in Tanzanians.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Phenotyping and genotyping of S-mephenytoin hydroxylase (cytochrome P450 2C19) in a Shona population of Zimbabwe

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

The role of S-mephenytoin 4'-hydroxylase in imipramine metabolism by human liver microsomes: a two-enzyme kinetic analysis of N-demethylation and 2-hydroxylation

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Genetically determined drug-metabolizing activity and desipramine-associated cardiotoxicity: a case report

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Diazepam metabolism in native Chinese poor and extensive hydroxylators of S-mephenytoin: interethnic differences in comparison with white subjects.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Why are diazepam metabolism and polymorphic S-mephenytoin hydroxylation associated with each other in white and Korean populations but not in Chinese populations?

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Proguanil metabolism is determined by the mephenytoin oxidation polymorphism in Vietnamese living in Denmark

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Proguanil polymorphism does not affect the antimalarial activity of proguanil combined with atovaquone in vitro.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Genetically determined oxidation capacity and the disposition of debrisoquine

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Defective N-oxidation of sparteine in man: A new pharmacogenetic defect

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

A family study of genetic and environmental factors determining polymorphic hydroxylation of debrisoquin

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

"It's the genes, stupid". Molecular bases and clinical consequences of genetic cytochrome P450 2D6 polymorphism

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Geographical/interracial differences in polymorphic drug oxidation. Current state of knowledge of cytochromes P450 (CYP) 2D6 and 2C19

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

The metabolism of aprindine in relation to the sparteine/debrisoquine polymorphism

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Discovery of altered pharmacokinetics of CGP 15 210 G in poor hydroxylators of debrisoquine during early drug development

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Steady-state plasma levels of clomipramine and its metabolites: impact of the sparteine/debrisoquine oxidation polymorphism. Danish University Antidepressant Group.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

The debrisoquine hydroxylation test predicts steady-state plasma levels of desipramine

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

The influence of the sparteine/debrisoquine genetic polymorphism on the disposition of dexfenfluramine

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

The influence of CYP2D6 polymorphism and quinidine on the disposition and antitussive effect of dextromethorphan in humans.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Is there a genetic factor in flecainide toxicity?

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

The disposition of fluoxetine but not sertraline is altered in poor metabolizers of debrisoquin

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Interindividual and interspecies variation in the metabolism of the hallucinogen 4-methoxyamphetamine

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Differential stereoselective metabolism of metoprolol in extensive and poor debrisoquin metabolizers

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Plasma concentrations of nortriptyline and its 10-hydroxy metabolite in depressed patients--relationship to the debrisoquine hydroxylation metabolic ratio

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Steady-state plasma levels of nortriptyline and its 10-hydroxy metabolite: relationship to the CYP2D6 genotype.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

The role of cytochrome P4502D6 in the metabolism of paroxetine by human liver microsomes

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Studies on the metabolism of perhexiline in man.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Impaired oxidation of debrisoquine in patients with perhexiline neuropathy

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Impaired oxidation of debrisoquine in patients with perhexiline liver injury

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

The CYP2D6 genotype predicts the oral clearance of the neuroleptic agents perphenazine and zuclopenthixol.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Genetic polymorphism of phenformin 4-hydroxylation

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

The role of genetically determined polymorphic drug metabolism in the beta-blockade produced by propafenone

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Pharmacokinetics of N-propylajmaline in relation to polymorphic sparteine oxidation

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Plasma levels of the enantiomers of thioridazine, thioridazine 2-sulfoxide, thioridazine 2-sulfone, and thioridazine 5-sulfoxide in poor and extensive metabolizers of dextromethorphan and mephenytoin.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Timolol and atenolol: relationships between oxidation phenotype, pharmacokinetics and pharmacodynamics

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Venlafaxine oxidation in vitro is catalysed by CYP2D6.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Disposition of the neuroleptic zuclopenthixol cosegregates with the polymorphic hydroxylation of debrisoquine in humans

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Formation of morphine from codeine in Chinese subjects of different CYP2D6 genotypes

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Chromosomal assignment of human cytochrome P-450 (debrisoquine/sparteine type) to chromosome 22.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

DNA haplotype-dependent differences in the amino acid sequence of debrisoquine 4-hydroxylase (CYP2D6): evidence for two major allozymes in extensive metabolisers

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Identification of the primary gene defect at the cytochrome P450 CYP2D locus.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Homologous unequal cross-over involving a 2.8 kb direct repeat as a mechanism for the generation of allelic variants of human cytochrome P450 CYP2D6 gene.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

An unequal cross-over event within the CYP2D gene cluster generates a chimeric CYP2D7/CYP2D6 gene which is associated with the poor metabolizer phenotype

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

A novel mutant variant of the CYP2D6 gene (CYP2D6*17) common in a black African population: association with diminished debrisoquine hydroxylase activity

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Frequency of human CYP2D6 mutant alleles in a normal Chinese population

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Debrisoquine/sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European population

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Functional properties of CYP2D6 1 (wild-type) and CYP2D6 7 (His324Pro) expressed by recombinant baculovirus in insect cells

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Polymorphic debrisoquine oxidation and acute neuroleptic-induced adverse effects

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

The pharmacogenetics of the selective serotonin reuptake inhibitors

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Patient-controlled analgesia (PCA) with codeine for postoperative pain relief in ten extensive metabolisers and one poor metaboliser of dextromethorphan

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

A Taq I polymorphism in the human P450IIE1 gene on chromosome 10 (CYP2E).

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Human ethanol-inducible P450IIE1: complete gene sequence, promoter characterization, chromosome mapping, and cDNA-directed expression

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Mspl polymorphism of the human CYP2E gene

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

PstI and RsaI RFLPs in complete linkage disequilibrium at the CYP2E gene

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Genetic polymorphism of cytochrome P4502E1 in a Swedish population. Relationship to incidence of lung cancer

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Genetic Polymorphisms in the 5′-Flanking Region Change Transcriptional Regulation of the Human Cytochrome P450IIE1 Gene1

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Different regulation and expression of the human CYP2E1 gene due to the RsaI polymorphism in the 5'-flanking region.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Nomenclature for human glutathione transferases

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Structure, catalytic mechanism, and evolution of the glutathione transferases

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Glutathione S-transferases: gene structure, regulation, and biological function

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Genetic heterogeneity of the human glutathione transferases: a complex of gene families

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Glutathione S-transferase class Kappa: characterization by the cloning of rat mitochondrial GST and identification of a human homologue

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Intracellular binding and transport of hormones and xenobiotics by glutathione-S-transferases

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Protective role of glutathione and glutathione transferases in mutagenesis and carcinogenesis

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

The role of glutathione and glutathione transferases in chemical carcinogenesis

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

The human liver glutathione S-transferase gene superfamily: expression and chromosome mapping of an Hbsubunit cDNA

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

The human Hb (mu) class glutathione S-transferases are encoded by a dispersed gene family

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Use of site-directed mutagenesis of allele-specific PCR primers to identify the GSTM1 A, GSTM1 B, GSTM1 A,B and GSTM1 null polymorphisms at the glutathione S-transferase, GSTM1 locus.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Heterologous expression of the allelic variant mu-class glutathione transferases mu and psi.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

DNA adducts in human placenta as related to air pollution and to GSTM1 genotype

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Polycyclic aromatic hydrocarbon-DNA adducts in smokers and their relationship to micronutrient levels and the glutathione-S-transferase M1 genotype.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Polycyclic aromatic hydrocarbon-DNA and protein adducts in coal tar treated patients and controls and their relationship to glutathione S-transferase genotype

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

The impact of glutathione s-transferase M1 and cytochrome P450 1A1 genotypes on white-blood-cell polycyclic aromatic hydrocarbon-DNA adduct levels in humans.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Environmental air pollution and DNA adducts in Copenhagen bus drivers--effect of GSTM1 and NAT2 genotypes on adduct levels

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

The human glutathione S-transferase supergene family, its polymorphism, and its effects on susceptibility to lung cancer

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Allelism at the glutathione S-transferase GSTM3 locus: interactions with GSTM1 and GSTT1 as risk factors for astrocytoma

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Chromosomal localization of the gene for the human theta class glutathione transferase (GSTT1)

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Metabolism of dichloromethane (methylene chloride) to formaldehyde in human erythrocytes: influence of polymorphism of glutathione transferase theta (GST T1-1).

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Human glutathione S-transferase T1-1 enhances mutagenicity of 1,2-dibromoethane, dibromomethane and 1,2,3,4-diepoxybutane in Salmonella typhimurium

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Bimodal distribution of sensitivity to SCE induction by diepoxybutane in human lymphocytes. II. Relationship to baseline SCE frequency

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Unsaturated lipids and intestinal bacteria as sources of endogenous production of ethene and ethylene oxide.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Bimodal distribution of sensitivity to SCE induction by diepoxybutane in human lymphocytes. I. Correlation with chromosomal aberrations

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Role of GSTT1 and GSTM1 genotypes in determining individual sensitivity to sister chromatid exchange induction by diepoxybutane in cultured human lymphocytes.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Aflatoxin B1 8,9-epoxide hydrolysis in the presence of rat and human epoxide hydrolase.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Characterization of the microsomal epoxide hydrolase gene in patients with anticonvulsant adverse drug reactions

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Effect of codeine on gastrointestinal motility in relation to CYP2D6 phenotype*

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Susceptibility markers in normal subjects: A pilot study for the investigation of 2,3,7,8-tetrachlorodibenzo-p-dioxin related diseases

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Polymorphic oxidation of sparteine and debrisoquine: Related pharmacogenetic entities

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Genetic analysis of microsomal epoxide hydrolase in patients with carbamazepine hypersensitivity

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

The Substrate Binding Site of Human Liver Cytochrome P450 2C9: An Approach Using Designed Tienilic Acid Derivatives and Molecular Modeling

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

S-mephenytoin hydroxylation phenotype and CYP2C19 genotype among Ethiopians.

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Genetically based N-acetyltransferase metabolic polymorphism and low-level environmental exposure to carcinogens

1 reference

https://api.crossref.org/works/10.1080%2F10408449991349186

21 January 2018

Identifiers

10.1080/10408449991349186

1 reference

Europe PubMed Central

27 July 2017

release_q2pshhjqa5a5fcgp5pnh4rj6na

1 reference

https://api.fatcat.wiki/v0/release/q2pshhjqa5a5fcgp5pnh4rj6na

24 November 2022

based on heuristic

mapped directly with Wikidata item

1 reference

Europe PubMed Central

27 July 2017

ResearchGate publication ID

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