(Q33942265)

30 July 2017

title

Computational design of membrane proteins. (English)

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30 July 2017

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computational biology

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2

Jeffery G Saven

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30 July 2017

author name string

Jose Manuel Perez-Aguilar

series ordinal

1

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30 July 2017

publication date

1 January 2012

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30 July 2017

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30 July 2017

volume

20

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30 July 2017

issue

1

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30 July 2017

page(s)

5-14

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NMR structure and dynamics of a designed water-soluble transmembrane domain of nicotinic acetylcholine receptor

30 July 2017

cites work

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5 July 2018

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Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family

5 July 2018

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Structure of the human histamine H1 receptor complex with doxepin

5 July 2018

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Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation

5 July 2018

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Principles of activation and permeation in an anion-selective Cys-loop receptor

5 July 2018

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Thermostabilisation of an agonist-bound conformation of the human adenosine A(2A) receptor

5 July 2018

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Computational protein design: engineering molecular diversity, nonnatural enzymes, nonbiological cofactor complexes, and membrane proteins

5 July 2018

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The dead-end elimination theorem and its use in protein side-chain positioning

5 July 2018

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Overcoming barriers to membrane protein structure determination

5 July 2018

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X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

5 July 2018

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Theoretical and computational protein design

5 July 2018

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Designing artificial enzymes by intuition and computation

5 July 2018

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Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

5 July 2018

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Membrane protein folding: how important are hydrogen bonds?

5 July 2018

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De novo design and molecular assembly of a transmembrane diporphyrin-binding protein complex.

5 July 2018

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Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists

5 July 2018

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Diffraction cartography: applying microbeams to macromolecular crystallography sample evaluation and data collection

5 July 2018

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Computational design and elaboration of a de novo heterotetrameric alpha-helical protein that selectively binds an emissive abiological (porphinato)zinc chromophore

5 July 2018

1 reference

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New tools for membrane protein research

5 July 2018

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Design of membrane proteins: toward functional systems

5 July 2018

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Computational analysis of membrane proteins: the largest class of drug targets.

5 July 2018

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Mapping the human membrane proteome: a majority of the human membrane proteins can be classified according to function and evolutionary origin

5 July 2018

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Biophysical dissection of membrane proteins.

5 July 2018

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Thermostabilization of the neurotensin receptor NTS1.

5 July 2018

1 reference

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Metal-binding dependent disruption of membranes by designed helices

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

Prediction of membrane protein structures with complex topologies using limited constraints

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

NMR studies of a channel protein without membranes: Structure and dynamics of water-solubilized KcsA

5 July 2018

1 reference

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The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist

5 July 2018

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Using alpha-helical coiled-coils to design nanostructured metalloporphyrin arrays

5 July 2018

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Co-evolving stability and conformational homogeneity of the human adenosine A2a receptor

5 July 2018

1 reference

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Computationally designed peptide inhibitors of protein-protein interactions in membranes

5 July 2018

1 reference

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Structure of a beta1-adrenergic G-protein-coupled receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

GFP-based optimization scheme for the overexpression and purification of eukaryotic membrane proteins in Saccharomyces cerevisiae

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

Conformational thermostabilization of the beta1-adrenergic receptor in a detergent-resistant form

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

Mutations affecting the oligomerization interface of G-protein-coupled receptors revealed by a novel de novo protein design framework

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

Toward high-resolution prediction and design of transmembrane helical protein structures

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

High-throughput fluorescent-based optimization of eukaryotic membrane protein overexpression and purification in Saccharomyces cerevisiae

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

De novo design of a single-chain diphenylporphyrin metalloprotein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

Computational protein design: structure, function and combinatorial diversity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

How many drug targets are there?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

Helix-packing motifs in membrane proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

Computer-based design of novel protein structures

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

Molecular Dynamics Simulation of WSK-3, a Computationally Designed, Water-Soluble Variant of the Integral Membrane Protein KcsA

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

Computational de novo design and characterization of a four-helix bundle protein that selectively binds a nonbiological cofactor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

Computational design of water-soluble analogues of the potassium channel KcsA

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

Computational design and characterization of a monomeric helical dinuclear metalloprotein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

Amphipols: polymeric surfactants for membrane biology research.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

Structure and gating mechanism of the acetylcholine receptor pore

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

Gating the selectivity filter in ClC chloride channels

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

The Calpha ---H...O hydrogen bond: a determinant of stability and specificity in transmembrane helix interactions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

Statistical theory for protein combinatorial libraries. Packing interactions, backbone flexibility, and the sequence variability of a main-chain structure.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

Native protein sequences are close to optimal for their structures

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

Crystal structure of rhodopsin: A G protein-coupled receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

Structure at 2.3 A resolution of the cytochrome bc(1) complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

The GxxxG motif: a framework for transmembrane helix-helix association

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

The role of position a in determining the stability and oligomerization state of alpha-helical coiled coils: 20 amino acid stability coefficients in the hydrophobic core of proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

Genome-wide analysis of integral membrane proteins from eubacterial, archaean, and eukaryotic organisms

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

De novo protein design: fully automated sequence selection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

De novo design of the hydrophobic cores of proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

A new approach to the design of stable proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

A switch between two-, three-, and four-stranded coiled coils in GCN4 leucine zipper mutants

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

Optimal sequence selection in proteins of known structure by simulated evolution

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

Structure at 2.8 A resolution of cytochrome c oxidase from Paracoccus denitrificans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

Computational design of peptides that target transmembrane helices.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

Design of a functional membrane protein by engineering a heme-binding site in glycophorin A.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

Activation of platelet alphaIIbbeta3 by an exogenous peptide corresponding to the transmembrane domain of alphaIIb.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

Effective energy function for proteins in lipid membranes

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

An improved tripod amphiphile for membrane protein solubilization.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

De novo design of integral membrane proteins

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

Ez, a Depth-dependent Potential for Assessing the Energies of Insertion of Amino Acid Side-chains into Membranes: Derivation and Applications to Determining the Orientation of Transmembrane and Interfacial Helices

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4108999

Synthetic amphiphilic peptide models for protein ion channels

29 October 2018

1 reference

12 December 2020

Characterization of a membrane protein folding motif, the Ser zipper, using designed peptides

1 reference

12 December 2020

Stability of 100 homo and heterotypic coiled-coil a-a' pairs for ten amino acids (A, L, I, V, N, K, S, T, E, and R)

1 reference

12 December 2020

Computational design of membrane proteins

1 reference

12 December 2020

Interhelical hydrogen bonding drives strong interactions in membrane proteins

1 reference

12 December 2020

Asparagine-mediated self-association of a model transmembrane helix

1 reference

12 December 2020

Experimental and computational evaluation of forces directing the association of transmembrane helices

1 reference

12 December 2020

10.1016/J.STR.2011.12.003

Identifiers

DOI

1 reference

30 July 2017

1 reference

30 July 2017

1 reference