(Q34013802)

30 July 2017

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title

Hypoxia modulated gene expression: angiogenesis, metastasis and therapeutic exploitation (English)

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30 July 2017

0 references

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Dachs GU

1

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30 July 2017

Tozer GM

series ordinal

2

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30 July 2017

publication date

1 August 2000

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European Journal of Cancer

30 July 2017

published in

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30 July 2017

volume

36

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30 July 2017

issue

13 Spec No

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30 July 2017

page(s)

1649-1660

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Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck

30 July 2017

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Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

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Regulation of c-jun expression during hypoxic and low-glucose stress

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7 January 2021

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

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7 January 2021

A 24-base-pair sequence 3' to the human erythropoietin gene contains a hypoxia-responsive transcriptional enhancer

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7 January 2021

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

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7 January 2021

Hypoxic induction of vascular endothelial growth factor (VEGF) in human epithelial cells is mediated by increases in mRNA stability

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7 January 2021

Prolonged in vivo hypoxia enhances nitric oxide synthase type I and type III gene expression in adult rat lung

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7 January 2021

A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter

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7 January 2021

Functional requirement of the hypoxia-responsive element in the activation of the inducible nitric oxide synthase promoter by the iron chelator desferrioxamine

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7 January 2021

Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand

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7 January 2021

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7 January 2021

Microenvironmental control of gene expression: implications for tumor angiogenesis, progression, and metastasis

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7 January 2021

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

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7 January 2021

General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia

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7 January 2021

Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism

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7 January 2021

In vivo expression of mRNAs encoding hypoxia-inducible factor 1

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7 January 2021

Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor

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7 January 2021

An essential role for p300/CBP in the cellular response to hypoxia

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7 January 2021

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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7 January 2021

Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein

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7 January 2021

Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha

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7 January 2021

Hypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction

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7 January 2021

Hypoxia-inducible protein binding to vascular endothelial growth factor mRNA and its modulation by the von Hippel-Lindau protein

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7 January 2021

aHIF: a natural antisense transcript overexpressed in human renal cancer and during hypoxia

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7 January 2021

Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha

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7 January 2021

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

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7 January 2021

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

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7 January 2021

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

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7 January 2021

Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway

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7 January 2021

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

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7 January 2021

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

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7 January 2021

Oxygen-regulated erythropoietin gene expression is dependent on a CpG methylation-free hypoxia-inducible factor-1 DNA-binding site

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7 January 2021

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

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7 January 2021

p53 inhibits hypoxia-inducible factor-stimulated transcription

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7 January 2021

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo.

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7 January 2021

Enhanced expression of vascular endothelial growth factor in metastatic melanoma

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7 January 2021

Vascular endothelial growth factor is up-regulated in the early pre-malignant stage of colorectal tumour progression

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7 January 2021

Clinical significance of microvessel density and vascular endothelial growth factor expression in hepatocellular carcinoma and surrounding liver: possible involvement of vascular endothelial growth factor in the angiogenesis of cirrhotic liver

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7 January 2021

Vascular endothelial growth factor increased by pulmonary surgery accelerates the growth of micrometastases in metastatic lung cancer

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7 January 2021

Stimulatory interaction between vascular endothelial growth factor and endothelin-1 on each gene expression

1 reference

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7 January 2021

Vascular endothelial growth factor expression is independent of hypoxia in human malignant glioma spheroids and tumours

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900159-3

7 January 2021

Hypoxia is a strong inducer of vascular endothelial growth factor mRNA expression in the heart

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900159-3

7 January 2021

Post-transcriptional regulation of vascular endothelial growth factor by hypoxia

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900159-3

7 January 2021

Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR

1 reference

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7 January 2021

Hypoxic regulation of vascular endothelial growth factor mRNA stability requires the cooperation of multiple RNA elements

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900159-3

7 January 2021

Translation of vascular endothelial growth factor mRNA by internal ribosome entry: implications for translation under hypoxia

1 reference

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7 January 2021

Regulation of vascular endothelial growth factor (VEGF) expression is mediated by internal initiation of translation and alternative initiation of transcription.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900159-3

7 January 2021

The vascular endothelial growth factor mRNA contains an internal ribosome entry site.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900159-3

7 January 2021

Prevention of hypoxia-induced apoptosis by the angiogenic factor thymidine phosphorylase.

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7 January 2021

The influence of elevated levels of platelet-derived endothelial cell growth factor/thymidine phosphorylase on tumourigenicity, tumour growth, and oxygenation

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7 January 2021

Platelet-derived endothelial cell growth factor expression correlates with tumour angiogenesis and prognosis in non-small-cell lung cancer

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7 January 2021

Nitric oxide in tumour biology and cancer therapy. Part 1: Physiological aspects

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7 January 2021

Nitric oxide in tumor biology and cancer therapy. Part 2: Therapeutic implications

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7 January 2021

Neuronal expression of inducible nitric oxide synthase after oxygen and glucose deprivation in rat forebrain slices.

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7 January 2021

Regulation of endothelial nitric-oxide synthase during hypoxia.

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7 January 2021

Regulation of bovine endothelial constitutive nitric oxide synthase by oxygen

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7 January 2021

Hypoxia decreases constitutive nitric oxide synthase transcript and protein in cultured endothelial cells

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7 January 2021

Endothelial cell responses to hypoxic stress

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7 January 2021

Oxygen tension regulates the nitric oxide pathway. Physiological role in penile erection

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7 January 2021

Nitric oxide binding to the heme of neuronal nitric-oxide synthase links its activity to changes in oxygen tension

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7 January 2021

Nitric oxide synthase activity in human breast cancer

1 reference

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7 January 2021

NG-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthesis, ameliorates interleukin 2-induced capillary leakage and reduces tumour growth in adenocarcinoma-bearing mice

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7 January 2021

Roles of nitric oxide in tumor growth

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7 January 2021

Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells

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7 January 2021

Role of nitric oxide in tumor progression: lessons from experimental tumors

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7 January 2021

Liver endothelial cells participate in T‐cell‐dependent host resistance to lymphoma metastasis by production of nitric oxide in vivo

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7 January 2021

Inhibitors of nitric oxide synthase selectively reduce flow in tumor-associated neovasculature

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https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900159-3

7 January 2021

Nitric oxide synthase inhibition irreversibly decreases perfusion in the R3230Ac rat mammary adenocarcinoma

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7 January 2021

Nitric oxide synthase inhibition by N(G)-nitro-L-arginine methyl ester inhibits tumor-induced angiogenesis in mammary tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900159-3

7 January 2021

Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900159-3

7 January 2021

Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis

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7 January 2021

Vascular endothelial growth factor-induced endothelial cell migration and proliferation depend on a nitric oxide-mediated decrease in protein kinase Cdelta activity

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7 January 2021

Role of endothelial nitric oxide synthase in endothelial cell migration

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7 January 2021

Vascular endothelial growth factor signals endothelial cell production of nitric oxide and prostacyclin through flk-1/KDR activation of c-Src

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7 January 2021

Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5' enhancer

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7 January 2021

Differential regulation of cardiac heme oxygenase-1 and vascular endothelial growth factor mRNA expressions by hemin, heavy metals, heat shock and anoxia

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900159-3

7 January 2021

Expression of heme oxygenase isozyme mRNAs in the human brain and induction of heme oxygenase-1 by nitric oxide donors

1 reference

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7 January 2021

The comparative effects of the NOS inhibitor, Nomega-nitro-L-arginine, and the haemoxygenase inhibitor, zinc protoporphyrin IX, on tumour blood flow.

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7 January 2021

An examination of the effects of hypoxia, acidosis, and glucose starvation on the expression of metastasis-associated genes in murine tumor cells.

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7 January 2021

Hypoxia stimulates proximal tubular cell matrix production via a TGF-beta1-independent mechanism

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7 January 2021

Significance of membrane type 1 matrix metalloproteinase expression in breast cancer.

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7 January 2021

Studies of type IV collagenase regulation by hypoxia

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7 January 2021

Hypoxia-mediated stimulation of carcinoma cell invasiveness via upregulation of urokinase receptor expression

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7 January 2021

Gene delivery to hypoxic cells in vitro

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7 January 2021

Targeting gene expression to hypoxic tumor cells

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7 January 2021

An adenoviral vector regulated by hypoxia for the treatment of ischaemic disease and cancer

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7 January 2021

Characterization of physiologically regulated vectors for the treatment of ischemic disease

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7 January 2021

Development of a hypoxia-responsive vector for tumor-specific gene therapy

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7 January 2021

Molecular chemotherapy for breast cancer

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7 January 2021

The macrophage - a novel system to deliver gene therapy to pathological hypoxia

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7 January 2021

10.1016/S0959-8049(00)00159-3

Identifiers

DOI

1 reference

30 July 2017

1 reference