(Q34024636)

30 July 2017

title

Gating-pore currents demonstrate selective and specific modulation of individual sodium channel voltage-sensors by biological toxins (English)

1 reference

30 July 2017

0 references

Yucheng Xiao

1

1 reference

30 July 2017

Kenneth Blumenthal

series ordinal

2

1 reference

30 July 2017

Theodore R Cummins

series ordinal

3

1 reference

30 July 2017

language of work or name

English

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publication date

4 June 2014

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30 July 2017

published in

Molecular Pharmacology

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30 July 2017

volume

86

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30 July 2017

issue

2

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30 July 2017

page(s)

159-167

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Domain IV voltage-sensor movement is both sufficient and rate limiting for fast inactivation in sodium channels.

30 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127926

Gating transitions in the selectivity filter region of a sodium channel are coupled to the domain IV voltage sensor

5 July 2018

1 reference

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A sodium channel knockin mutant (NaV1.4-R669H) mouse model of hypokalemic periodic paralysis

5 July 2018

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Common molecular determinants of tarantula huwentoxin-IV inhibition of Na+ channel voltage sensors in domains II and IV

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127926

The tarantula toxins ProTx-II and huwentoxin-IV differentially interact with human Nav1.7 voltage sensors to inhibit channel activation and inactivation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127926

Ion permeation and block of the gating pore in the voltage sensor of NaV1.4 channels with hypokalemic periodic paralysis mutations

5 July 2018

1 reference

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Depolarization-activated gating pore current conducted by mutant sodium channels in potassium-sensitive normokalemic periodic paralysis

5 July 2018

1 reference

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Deconstructing voltage sensor function and pharmacology in sodium channels

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127926

ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action potential propagation in nociceptors.

5 July 2018

1 reference

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Evidence for multiple effects of ProTxII on activation gating in Na(V)1.5.

5 July 2018

1 reference

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Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configuration

5 July 2018

1 reference

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How membrane proteins sense voltage

5 July 2018

1 reference

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Inhibition of sodium channel gating by trapping the domain II voltage sensor with protoxin II.

5 July 2018

1 reference

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A Na+ channel mutation linked to hypokalemic periodic paralysis exposes a proton-selective gating pore

5 July 2018

1 reference

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Molecular interactions of the gating modifier toxin ProTx-II with NaV 1.5: implied existence of a novel toxin binding site coupled to activation

5 July 2018

1 reference

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Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes

5 July 2018

1 reference

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Inherited disorders of voltage-gated sodium channels

5 July 2018

1 reference

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Voltage-gated sodium channel toxins: poisons, probes, and future promise

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127926

Two tarantula peptides inhibit activation of multiple sodium channels

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127926

Molecular basis of an inherited epilepsy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127926

Molecular mechanisms of gating and drug block of sodium channels

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127926

Sodium channels and their genes: dynamic expression in the normal nervous system, dysregulation in disease states(1).

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127926

Molecular mechanisms of neurotoxin action on voltage-gated sodium channels.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127926

The Na channel voltage sensor associated with inactivation is localized to the external charged residues of domain IV, S4.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127926

A specific interaction between the cardiac sodium channel and site-3 toxin anthopleurin B.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127926

A unique role for the S4 segment of domain 4 in the inactivation of sodium channels

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127926

Cloning and expression of wild-type and mutant forms of the cardiotonic polypeptide anthopleurin B.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127926

A mutant of TTX-resistant cardiac sodium channels with TTX-sensitive properties

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127926

Inactivation of the sodium channel. I. Sodium current experiments

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127926

Gating pore current in an inherited ion channelopathy.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127926

The twisted ion-permeation pathway of a resting voltage-sensing domain

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127926

Ion permeation through a voltage- sensitive gating pore in brain sodium channels having voltage sensor mutations

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127926

Voltage-sensing arginines in a potassium channel permeate and occlude cation-selective pores

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127926

A proton pore in a potassium channel voltage sensor reveals a focused electric field

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127926

The position of the fourth segment of domain 4 determines status of the inactivation gate in Na+ channels.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4127926

Differential phospholipid binding by site 3 and site 4 toxins. Implications for structural variability between voltage-sensitive sodium channel domains

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24898004

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A reinterpretation of mammalian sodium channel gating based on single channel recording

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24898004

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1124/MOL.114.092338

1 reference

30 July 2017

1 reference

30 July 2017

1 reference