(Q34030874)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22373667%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

title

A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22373667%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

1 reference

1 reference

1 reference

2

1 reference

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24 January 2020

Mark Stahl

11

1 reference

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24 January 2020

author name string

Shubhangi Prabhudesai

1

1 reference

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24 January 2020

Aida Attar

3

1 reference

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24 January 2020

Aswani Kotagiri

4

1 reference

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24 January 2020

Arthur G Fitzmaurice

5

1 reference

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24 January 2020

Rajeswari Lakshmanan

6

1 reference

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24 January 2020

Magdalena I Ivanova

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22373667%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Joseph A Loo

8

1 reference

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24 January 2020

Frank-Gerrit Klärner

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22373667%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Thomas Schrader

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22373667%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Gal Bitan

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22373667%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Jeff M Bronstein

13

1 reference

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24 January 2020

publication date

1 April 2012

1 reference

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24 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22373667%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

volume

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22373667%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22373667%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

page(s)

464-476

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22373667%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1007/s13311-012-0105-1

24 January 2020

exact match

0 references

cites work

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28 July 2018

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Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

1 reference

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C-terminal peptides coassemble into Abeta42 oligomers and protect neurons against Abeta42-induced neurotoxicity

28 July 2018

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28 July 2018

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Design of an N-methylated peptide inhibitor of alpha-synuclein aggregation guided by solid-state NMR.

28 July 2018

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Curcumin inhibits aggregation of alpha-synuclein

28 July 2018

1 reference

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Impairment of the ubiquitin-proteasome pathway is a downstream endoplasmic reticulum stress response induced by extracellular human islet amyloid polypeptide and contributes to pancreatic beta-cell apoptosis

28 July 2018

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Abeta inhibits the proteasome and enhances amyloid and tau accumulation

28 July 2018

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Proteasome inhibition and Parkinson's disease modeling

28 July 2018

1 reference

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Inhibitors of alpha-synuclein oligomerization and toxicity: a future therapeutic strategy for Parkinson's disease and related disorders

28 July 2018

1 reference

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Small molecule inhibitors of alpha-synuclein filament assembly

28 July 2018

1 reference

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Inhibitory effects of pesticides on proteasome activity: implication in Parkinson's disease

28 July 2018

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Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Alpha-synuclein in Lewy bodies

28 July 2018

1 reference

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Acute polyglutamine expression in inducible mouse model unravels ubiquitin/proteasome system impairment and permanent recovery attributable to aggregate formation.

28 July 2018

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Seeding induced by alpha-synuclein oligomers provides evidence for spreading of alpha-synuclein pathology

29 October 2018

1 reference

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Inhibition of alpha-synuclein fibril assembly by small molecules: analysis using epitope-specific antibodies.

29 October 2018

1 reference

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Characterization of housekeeping genes in zebrafish: male-female differences and effects of tissue type, developmental stage and chemical treatment

29 October 2018

1 reference

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Ziram causes dopaminergic cell damage by inhibiting E1 ligase of the proteasome.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337029

Cell-produced alpha-synuclein oligomers are targeted to, and impair, the 26S proteasome

29 October 2018

1 reference

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Characterization of alpha-synuclein interactions with selected aggregation-inhibiting small molecules

29 October 2018

1 reference

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Aggregator compounds confound amyloid fibrillization assay

29 October 2018

1 reference

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Small-molecule aggregates inhibit amyloid polymerization

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337029

Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337029

Proteasomal inhibition causes loss of nigral tyrosine hydroxylase neurons.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337029

Reproducible nigral cell loss after systemic proteasomal inhibitor administration to rats.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337029

Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeys.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337029

Lack of nigrostriatal pathology in a rat model of proteasome inhibition.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337029

A molecular tweezer for lysine and arginine

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337029

Neurotoxic protein oligomers--what you see is not always what you get.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337029

Rifampicin inhibits alpha-synuclein fibrillation and disaggregates fibrils

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337029

Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337029

Dopamine and L-dopa disaggregate amyloid fibrils: implications for Parkinson's and Alzheimer's disease

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337029

Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337029

Failure of the ubiquitin-proteasome system in Parkinson's disease

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337029

Impairment of the ubiquitin-proteasome system by protein aggregation

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337029

Proteasomal function is impaired in substantia nigra in Parkinson's disease

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3337029

Dark-induced changes in activity and compartmentalization of retinal calmodulin kinase in the rat

29 October 2018

1 reference

12 December 2020

Genetics of Parkinson's disease

1 reference

12 December 2020

[18] Quantification of β-sheet amyloid fibril structures with thioflavin T

1 reference

12 December 2020

Proteasome inhibitor-induced model of Parkinson's disease

1 reference

12 December 2020

alpha-Synuclein protofibrils inhibit 26 S proteasome-mediated protein degradation: understanding the cytotoxicity of protein protofibrils in neurodegenerative disease pathogenesis.

1 reference

12 December 2020

Clues to how alpha-synuclein damages neurons in Parkinson's disease

1 reference

12 December 2020

10.1007/S13311-012-0105-1

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22373667%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22373667%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22373667%20AND%20SRC:MED&resulttype=core&format=json