(Q36492162)

14 August 2017

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title

Inhibitors of alpha-synuclein oligomerization and toxicity: a future therapeutic strategy for Parkinson's disease and related disorders (English)

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14 August 2017

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Dena A M Amer

1

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14 August 2017

G Brent Irvine

series ordinal

2

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14 August 2017

Omar M A El-Agnaf

series ordinal

3

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14 August 2017

publication date

30 May 2006

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Experimental Brain Research

14 August 2017

published in

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14 August 2017

volume

173

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14 August 2017

issue

2

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14 August 2017

page(s)

223-233

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alpha-synuclein promotes mitochondrial deficit and oxidative stress

14 August 2017

cites work

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Crossref

https://api.crossref.org/works/10.1007%2FS00221-006-0539-Y

Properties of NACP/alpha-synuclein and its role in Alzheimer's disease

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00221-006-0539-Y

Beta-synuclein gene alterations in dementia with Lewy bodies

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00221-006-0539-Y

Oligomerization and toxicity of beta-amyloid-42 implicated in Alzheimer's disease.

21 January 2018

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12 December 2020

Review: formation and properties of amyloid-like fibrils derived from alpha-synuclein and related proteins

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12 December 2020

alpha-Synuclein shares physical and functional homology with 14-3-3 proteins

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12 December 2020

Identification of the region of non-Abeta component (NAC) of Alzheimer's disease amyloid responsible for its aggregation and toxicity

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12 December 2020

Inhibition of fibril formation and toxicity of a fragment of alpha-synuclein by an N-methylated peptide analogue

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12 December 2020

Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma

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12 December 2020

Identification of two distinct synucleins from human brain

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12 December 2020

Overexpression of synuclein-gamma in pancreatic adenocarcinoma

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12 December 2020

A structural and functional role for 11-mer repeats in alpha-synuclein and other exchangeable lipid binding proteins

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12 December 2020

Alpha-synuclein aggregation in neurodegenerative diseases and its inhibition as a potential therapeutic strategy

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12 December 2020

Characterization of a novel protein regulated during the critical period for song learning in the zebra finch.

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12 December 2020

Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization

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12 December 2020

The human NACP/α-synuclein gene: chromosome assignment to 4q21.3–q22 and TaqI RFLP analysis

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12 December 2020

Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

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12 December 2020

Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

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12 December 2020

Immunoelectron-microscopic demonstration of NACP/alpha-synuclein-epitopes on the filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies

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12 December 2020

Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain

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12 December 2020

Inhibition of toxicity in the beta-amyloid peptide fragment beta -(25-35) using N-methylated derivatives: a general strategy to prevent amyloid formation.

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12 December 2020

Chaperone-like activity of synucleins

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12 December 2020

Expression and structural analysis of 14-3-3 proteins.

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12 December 2020

Fe(II)‐induced DNA damage in α‐synuclein‐transfected human dopaminergic BE(2)‐M17 neuroblastoma cells: detection by the Comet assay

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12 December 2020

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

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12 December 2020

Beta-synuclein displays an antiapoptotic p53-dependent phenotype and protects neurons from 6-hydroxydopamine-induced caspase 3 activation: cross-talk with alpha-synuclein and implication for Parkinson's disease

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12 December 2020

Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells.

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12 December 2020

Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal

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12 December 2020

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

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12 December 2020

Parkinson's disease. Second of two parts

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12 December 2020

Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration

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12 December 2020

Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing

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12 December 2020

Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration

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12 December 2020

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

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12 December 2020

Conformational properties of alpha-synuclein in its free and lipid-associated states

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12 December 2020

Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease

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12 December 2020

Inhibition of Alzheimer's amyloidosis by peptides that prevent beta-sheet conformation

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12 December 2020

beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor

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12 December 2020

Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease

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12 December 2020

Alpha-synuclein regulates neuronal survival via Bcl-2 family expression and PI3/Akt kinase pathway

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12 December 2020

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

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12 December 2020

Synthetic filaments assembled from C-terminally truncated alpha-synuclein

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12 December 2020

Stimulation of breast cancer invasion and metastasis by synuclein gamma

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12 December 2020

Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments

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12 December 2020

Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons

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12 December 2020

Non-fibrillar oligomeric species of the amyloid ABri peptide, implicated in familial British dementia, are more potent at inducing apoptotic cell death than protofibrils or mature fibrils

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12 December 2020

Synucleins in ocular tissues

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12 December 2020

alpha-Synuclein promoter confers susceptibility to Parkinson's disease.

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12 December 2020

alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease

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12 December 2020

Tat-mediated delivery of heterologous proteins into cells

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12 December 2020

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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12 December 2020

A Truncated HIV-1 Tat Protein Basic Domain Rapidly Translocates through the Plasma Membrane and Accumulates in the Cell Nucleus

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12 December 2020

alpha-Synuclein locus triplication causes Parkinson's disease

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12 December 2020

Assignment of human alpha-synuclein (SNCA) and beta-synuclein (SNCB) genes to chromosomes 4q21 and 5q35.

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12 December 2020

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease

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12 December 2020

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12 December 2020

Soluble oligomers for the diagnosis of neurodegenerative diseases

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12 December 2020

Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion

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12 December 2020

Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease

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12 December 2020

The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

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12 December 2020

Metal-catalyzed oxidation of alpha-synuclein in the presence of Copper(II) and hydrogen peroxide.

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12 December 2020

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12 December 2020

Wild-type but not Parkinson's disease-related ala-53 --> Thr mutant alpha -synuclein protects neuronal cells from apoptotic stimuli

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12 December 2020

Polyarginine enters cells more efficiently than other polycationic homopolymers

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12 December 2020

Stages in the development of Parkinson's disease-related pathology

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12 December 2020

Copper(II)-induced self-oligomerization of alpha-synuclein.

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12 December 2020

TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors

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12 December 2020

Diagnostic potential in bladder cancer of a panel of tumor markers (calreticulin, gamma -synuclein, and catechol-o-methyltransferase) identified by proteomic analysis

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12 December 2020

Prevalence of parkinsonism and Parkinson's disease in Europe: the EUROPARKINSON Collaborative Study. European Community Concerted Action on the Epidemiology of Parkinson's disease

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12 December 2020

Development of a new treatment for Alzheimer's disease and Parkinson's disease using anti-aggregatory beta-synuclein-derived peptides

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12 December 2020

The NACP/synuclein gene: chromosomal assignment and screening for alterations in Alzheimer disease

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12 December 2020

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

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12 December 2020

Distinct roles of the N-terminal-binding domain and the C-terminal-solubilizing domain of alpha-synuclein, a molecular chaperone

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12 December 2020

Immunohistochemistry of neuronal inclusions in the cerebral cortex and brain-stem in Lewy body disease

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12 December 2020

A high-efficiency protein transduction system demonstrating the role of PKA in long-lasting long-term potentiation.

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12 December 2020

Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta- and gamma-synucleins

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12 December 2020

The expression of alpha-, beta-, and gamma-synucleins in olfactory mucosa from patients with and without neurodegenerative diseases

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12 December 2020

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

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12 December 2020

The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters

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12 December 2020

Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

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12 December 2020

Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy

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12 December 2020

Alpha-synuclein and Parkinson's disease

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12 December 2020

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12 December 2020

Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

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12 December 2020

Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells.

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12 December 2020

Human recombinant NACP/alpha-synuclein is aggregated and fibrillated in vitro: relevance for Lewy body disease

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12 December 2020

Ultrastructural observations in Parkinsonism

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12 December 2020

alpha-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress-signaling pathway in neuronal cells

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12 December 2020

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

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12 December 2020

Structural and functional implications of C-terminal regions of alpha-synuclein

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12 December 2020

Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro

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12 December 2020

A Drosophila model of Parkinson's disease

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12 December 2020

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

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12 December 2020

Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

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12 December 2020

Ageing and Parkinson's disease: substantia nigra regional selectivity

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12 December 2020

alpha-Synuclein is phosphorylated in synucleinopathy lesions

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12 December 2020

Dopamine promotes alpha-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway

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12 December 2020

Characterization of the human alpha-synuclein gene: Genomic structure, transcription start site, promoter region and polymorphisms.

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12 December 2020

A broken alpha -helix in folded alpha -Synuclein

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12 December 2020

Alpha-synuclein and neurodegenerative diseases

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12 December 2020

Persyn, a member of the synuclein family, has a distinct pattern of expression in the developing nervous system

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12 December 2020

Gamma synuclein, a novel heat-shock protein-associated chaperone, stimulates ligand-dependent estrogen receptor alpha signaling and mammary tumorigenesis

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12 December 2020

Transcriptional suppression of synuclein gamma (SNCG) expression in human breast cancer cells by the growth inhibitory cytokine oncostatin M.

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12 December 2020

Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity

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12 December 2020

alpha-Synuclein implicated in Parkinson's disease catalyses the formation of hydrogen peroxide in vitro

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12 December 2020

14-3-3 proteins are involved in the regulation of mammalian cell proliferation.

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12 December 2020

Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations

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12 December 2020

beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease

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12 December 2020

Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies

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12 December 2020

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12 December 2020

Identification, localization and characterization of the human gamma-synuclein gene

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12 December 2020

Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death.

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12 December 2020

Evidence for a partially folded intermediate in alpha-synuclein fibril formation

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12 December 2020

A strategy for designing inhibitors of alpha-synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders

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12 December 2020

Depression in alpha-synucleinopathies: prevalence, pathophysiology and treatment

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12 December 2020

Reduced and oxidized glutathione in the substantia nigra of patients with Parkinson's disease

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12 December 2020

Organization, expression and polymorphism of the human persyn gene

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12 December 2020

Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies

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12 December 2020

Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery

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12 December 2020

10.1007/S00221-006-0539-Y

Identifiers

DOI

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14 August 2017

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