(Q45296946)

English

Acute polyglutamine expression in inducible mouse model unravels ubiquitin/proteasome system impairment and permanent recovery attributable to aggregate formation.

scientific article published in March 2010

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20220001%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Acute polyglutamine expression in inducible mouse model unravels ubiquitin/proteasome system impairment and permanent recovery attributable to aggregate formation (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20220001%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

ubiquitin-proteasome system

0 references

Nico P. Dantuma

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20220001%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20220001%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Miguel Diaz-Hernandez

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20220001%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Felix Hernandez

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20220001%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

author name string

Zaira Ortega

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20220001%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Christa J Maynard

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20220001%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

language of work or name

0 references

publication date

1 March 2010

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20220001%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20220001%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

30

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20220001%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

10

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20220001%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

3675-3688

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20220001%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6632247/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Detection of polyglutamine aggregation in mouse models

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Possible involvement of proteasome inhibition in aging: implications for oxidative stress.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased levels of proteasome activity and proteasome expression in aging spinal cord

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aggresomes, inclusion bodies and protein aggregation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impairment of the ubiquitin-proteasome system by protein aggregation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The axial channel of the proteasome core particle is gated by the Rpt2 ATPase and controls both substrate entry and product release

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteasomal-dependent aggregate reversal and absence of cell death in a conditional mouse model of Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Requirement of an intact microtubule cytoskeleton for aggregation and inclusion body formation by a mutant huntingtin fragment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A transgenic mouse model of the ubiquitin/proteasome system

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal induction of the immunoproteasome in Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Testing the ubiquitin-proteasome hypothesis of neurodegeneration in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular pathways to neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein aggregation and neurodegenerative disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generalized brain and skin proteasome inhibition in Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical, ultrastructural, and reversibility studies on huntingtin filaments isolated from mouse and human brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal dysfunction in a polyglutamine disease model occurs in the absence of ubiquitin-proteasome system impairment and inversely correlates with the degree of nuclear inclusion formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of the benzothiazole aggregation inhibitors riluzole and PGL-135 as therapeutics for Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Full motor recovery despite striatal neuron loss and formation of irreversible amyloid-like inclusions in a conditional mouse model of Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteasome impairment does not contribute to pathogenesis in R6/2 Huntington's disease mice: exclusion of proteasome activator REGgamma as a therapeutic target

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of 26S proteasome activity by huntingtin filaments but not inclusion bodies isolated from mouse and human brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trinucleotide Repeat Disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disease-associated prion protein oligomers inhibit the 26S proteasome

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Is the ubiquitin-proteasome system impaired in Huntington's disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Global changes to the ubiquitin system in Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ubiquitin proteasome system in Huntington's disease and the spinocerebellar ataxias

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A common motif targets huntingtin and the androgen receptor to the proteasome

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Compensatory changes in the ubiquitin-proteasome system, brain-derived neurotrophic factor and mitochondrial complex II/III in YAC72 and R6/2 transgenic mice partially model Huntington's disease patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional alterations of the ubiquitin-proteasome system in motor neurons of a mouse model of familial amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

17-DMAG ameliorates polyglutamine-mediated motor neuron degeneration through well-preserved proteasome function in an SBMA model mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single neuron ubiquitin-proteasome dynamics accompanying inclusion body formation in huntington disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ubiquitin-proteasome reporter GFPu does not accumulate in neurons of the R6/2 transgenic mouse model of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A critical evaluation of the ubiquitin-proteasome system in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytomegalovirus promoter up-regulation is the major cause of increased protein levels of unstable reporter proteins after treatment of living cells with proteasome inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of inhibitory synapses among striatal neurons in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Primary culture of identified neurons from the visual cortex of postnatal rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of memory formation through regulated expression of a CaMKII transgene

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intranuclear neuronal inclusions: a common pathogenic mechanism for glutamine-repeat neurodegenerative diseases?

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ubiquitin system

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aggresomes: a cellular response to misfolded proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/20220001

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.5673-09.2010

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20220001%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20220001%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20220001%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q45296946&oldid=1660012366"