(Q34032001)

English

Insulin stimulates human skeletal muscle protein synthesis via an indirect mechanism involving endothelial-dependent vasodilation and mammalian target of rapamycin complex 1 signaling

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scholarly article

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Europe PubMed Central

PubMed publication ID

30 July 2017

Insulin stimulates human skeletal muscle protein synthesis via an indirect mechanism involving endothelial-dependent vasodilation and mammalian target of rapamycin complex 1 signaling (English)

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

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1 reference

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1 reference

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Micah J Drummond

7

object named as

Micah J Drummond

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Blake B. Rasmussen

9

object named as

Blake B Rasmussen

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Europe PubMed Central

PubMed publication ID

30 July 2017

Kyle L Timmerman

1

object named as

Kyle L Timmerman

1 reference

Europe PubMed Central

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30 July 2017

5

object named as

Erin L Glynn

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Christopher S Fry

6

object named as

Christopher S Fry

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

3

object named as

Hans C Dreyer

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Shaheen Dhanani

4

object named as

Shaheen Dhanani

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

author name string

Jessica L Lee

2

1 reference

Europe PubMed Central

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30 July 2017

Melinda Sheffield-Moore

8

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Europe PubMed Central

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30 July 2017

Elena Volpi

10

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Europe PubMed Central

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30 July 2017

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publication date

19 May 2010

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Europe PubMed Central

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30 July 2017

The Journal of Clinical Endocrinology and Metabolism

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Europe PubMed Central

PubMed publication ID

30 July 2017

95

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

3848-3857

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Golgi and sarcolemmal neuronal NOS differentially regulate contraction-induced fatigue and vasoconstriction in exercising mouse skeletal muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

NOS inhibition blunts and delays the compensatory dilation in hypoperfused contracting human muscles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

Supraphysiological hyperinsulinaemia is necessary to stimulate skeletal muscle protein anabolism in older adults: evidence of a true age-related insulin resistance of muscle protein metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

Endotoxin and interferon-gamma inhibit translation in skeletal muscle cells by stimulating nitric oxide synthase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

Differential regulation of protein synthesis by amino acids and insulin in peripheral and visceral tissues of neonatal pigs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

Signaling in muscle atrophy and hypertrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

Insulin signaling stimulates insulin transport by bovine aortic endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

Aerobic exercise overcomes the age-related insulin resistance of muscle protein metabolism by improving endothelial function and Akt/mammalian target of rapamycin signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

Effect of insulin on human skeletal muscle protein synthesis is modulated by insulin-induced changes in muscle blood flow and amino acid availability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

Obesity blunts insulin-mediated microvascular recruitment in human forearm muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

The vascular endothelial cell mediates insulin transport into skeletal muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

Insulin resistance of muscle protein metabolism in aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

Regulation of the small GTPase Rheb by amino acids.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

Rheb binds and regulates the mTOR kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

Microvascular recruitment is an early insulin effect that regulates skeletal muscle glucose uptake in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

The vasodilatory actions of insulin on resistance and terminal arterioles and their impact on muscle glucose uptake

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

Molecular and physiologic actions of insulin related to production of nitric oxide in vascular endothelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

Inhibiting NOS blocks microvascular recruitment and blunts muscle glucose uptake in response to insulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

Regulation of mammalian translation factors by nutrients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

Skeletal muscle microvascular recruitment by physiological hyperinsulinemia precedes increases in total blood flow

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

Extreme hyperinsulinemia unmasks insulin's effect to stimulate protein synthesis in the human forearm.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

Quantification of myocardial blood flow with ultrasound-induced destruction of microbubbles administered as a constant venous infusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

Mechanism of activation of protein kinase B by insulin and IGF-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

Physiologic hyperinsulinemia stimulates protein synthesis and enhances transport of selected amino acids in human skeletal muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

Leg Blood Flow during Exercise in Man

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

Effects of acute systemic hyperinsulinemia on forearm muscle proteolysis in healthy man.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

Protein Anabolic Actions of Insulin in the Human Body

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

Effect of hyperinsulinemia on whole body and skeletal muscle leucine carbon kinetics in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

5 July 2018

The role of FOXO in the regulation of metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

29 October 2018

Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

29 October 2018

Mixed meal and light exercise each recruit muscle capillaries in healthy humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

29 October 2018

Differential regulation of protein dynamics in splanchnic and skeletal muscle beds by insulin and amino acids in healthy human subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

29 October 2018

Endothelin contributes to basal vascular tone and endothelial dysfunction in human obesity and type 2 diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

29 October 2018

Insulin and amino acids independently stimulate skeletal muscle protein synthesis in neonatal pigs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

29 October 2018

Insulin-mediated increase in blood flow is impaired in the elderly.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913031

29 October 2018

Euglycemic hyperinsulinemia augments amino acid uptake by human leg tissues during hyperaminoacidemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/20484484

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolysis in skeletal muscle and whole body in response to euglycemic hyperinsulinemia in normal adults

1 reference

https://pubmed.ncbi.nlm.nih.gov/20484484

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth hormone and insulin combine to improve whole-body and skeletal muscle protein kinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/20484484

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of systemic hyperinsulinemia with concomitant amino acid infusion on skeletal muscle protein turnover in the human forearm

1 reference

https://pubmed.ncbi.nlm.nih.gov/20484484

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin selectively attenuates breakdown of nonmyofibrillar proteins in peripheral tissues of normal men

1 reference

https://pubmed.ncbi.nlm.nih.gov/20484484

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction between insulin sensitivity and muscle perfusion on glucose uptake in human skeletal muscle: evidence for capillary recruitment

1 reference

https://pubmed.ncbi.nlm.nih.gov/20484484

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin and diabetes cause reciprocal changes in the association of eIF-4E and PHAS-I in rat skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/20484484

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct vasodilator effects of physiological hyperinsulin-aemia in human skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/20484484

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin stimulates protein synthesis in skeletal muscle by enhancing the association of eIF-4E and eIF-4G

1 reference

https://pubmed.ncbi.nlm.nih.gov/20484484

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1210/JC.2009-2696

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

ResearchGate publication ID

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