(Q34036225)

30 July 2017

title

CpG site degeneration triggered by the loss of functional constraint created a highly polymorphic macaque drug-metabolizing gene, CYP1A2. (English)

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30 July 2017

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2

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30 July 2017

Yasuhiro Uno

1

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ORCID Public Data File 2021

publication date

1 October 2011

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30 July 2017

published in

BMC Evolutionary Biology

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30 July 2017

volume

11

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30 July 2017

page(s)

283

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MEGA5: Molecular Evolutionary Genetics Analysis Using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods

30 July 2017

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1 reference

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CYP1D1, pseudogenized in human, is expressed and encodes a functional drug-metabolizing enzyme in cynomolgus monkey

5 July 2018

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5 July 2018

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Mutations of different molecular origins exhibit contrasting patterns of regional substitution rate variation

5 July 2018

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Expressed sequence tags from cynomolgus monkey (Macaca fascicularis) liver: a systematic identification of drug-metabolizing enzymes

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Adaptation or biased gene conversion? Extending the null hypothesis of molecular evolution

5 July 2018

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Rate of evolution in brain-expressed genes in humans and other primates

5 July 2018

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Higher intensity of purifying selection on >90% of the human genes revealed by the intrinsic replacement mutation rates

5 July 2018

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Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412

5 July 2018

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Balancing selection and its effects on sequences in nearby genome regions

5 July 2018

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A map of recent positive selection in the human genome

5 July 2018

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Concerted and birth-and-death evolution of multigene families

5 July 2018

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CYP3A variation and the evolution of salt-sensitivity variants

5 July 2018

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Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants

5 July 2018

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The effect of gene conversion on the divergence between duplicated genes

5 July 2018

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5 July 2018

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Structural and functional divergence of insect CYP6B proteins: From specialist to generalist cytochrome P450

5 July 2018

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Neutral Substitutions Occur at a Faster Rate in Exons Than in Noncoding DNA in Primate Genomes

5 July 2018

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Gene conversion drives GC content evolution in mammalian histones

5 July 2018

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5 July 2018

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Evolutionary recruitment of a flavin-dependent monooxygenase for the detoxification of host plant-acquired pyrrolizidine alkaloids in the alkaloid-defended arctiid moth Tyria jacobaeae

5 July 2018

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5 July 2018

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Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation

5 July 2018

1 reference

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5 July 2018

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Concise review of the cytochrome P450s and their roles in toxicology

5 July 2018

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When less is more: gene loss as an engine of evolutionary change

5 July 2018

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5 July 2018

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5 July 2018

CpG islands and genes

1 reference

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A test of neutral molecular evolution based on nucleotide data

5 July 2018

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5 July 2018

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Host factors in lung cancer risk: a review of interdisciplinary studies

5 July 2018

1 reference

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CYP1A2 is more variable than previously thought: a genomic biography of the gene behind the human drug-metabolizing enzyme

5 July 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2148-11-283

Ancient genome-wide admixture extends beyond the current hybrid zone between Macaca fascicularis and M. mulatta

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2148-11-283

Molecular cloning and functional analysis of cynomolgus monkey CYP1A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2148-11-283

A revised evolutionary history of the CYP1A subfamily: gene duplication, gene conversion, and positive selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2148-11-283

Evolution of the CYP2D gene cluster in humans and four non-human primates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2148-11-283

The effect of reciprocal active site mutations in human cytochromes P450 1A1 and 1A2 on alkoxyresorufin metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2148-11-283

Genetic variants of CYP3A4 and CYP3A5 in cynomolgus and rhesus macaques.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2148-11-283

A newly developed DNA microarray is useful to assess induction of cytochromes p450 in the cynomolgus monkey.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-2148-11-283

Contribution of CYP1A1 and CYP1A2 to the activation of heterocyclic amines in monkeys and human

21 January 2018

1 reference

12 December 2020

Molecular cloning of CYP1A from the estuarine fish Fundulus heteroclitus and phylogenetic analysis of CYP1 genes: update with new sequences

1 reference

12 December 2020

Selection to maintain paralogous amino acid differences under the pressure of gene conversion in the heat-shock protein genes in yeast

1 reference

12 December 2020

Comparison of inducibility of CYP1A and CYP3A mRNAs by prototypical inducers in primary cultures of human, cynomolgus monkey, and rat hepatocytes

1 reference

12 December 2020

Identifiers

DOI

10.1186/1471-2148-11-283

1 reference

Dimensions Publication ID

30 July 2017

0 references

1 reference

30 July 2017

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