(Q34040248)

30 July 2017

1 reference

title

Virulence and pathogenesis of HIV-1 infection: an evolutionary perspective (English)

1 reference

30 July 2017

0 references

7

1 reference

30 July 2017

Gabriel E Leventhal

3

0 references

Deirdre Hollingsworth

T Déirdre Hollingsworth

5

0 references

Christophe Fraser

Christophe Fraser

1

0 references

Samuel Alizon

Samuel Alizon

6

0 references

Katrina A Lythgoe

Katrina Lythgoe

2

0 references

author name string

George Shirreff

4

1 reference

PubMed ID

24653038

30 July 2017

language of work or name

English

0 references

publication date

1 March 2014

1 reference

30 July 2017

1 reference

30 July 2017

343

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30 July 2017

6177

1 reference

30 July 2017

1243727

1 reference

How effectively can HIV phylogenies be used to measure heritability?

30 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Is HIV short-sighted? Insights from a multistrain nested model

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Within-host and between-host evolutionary rates across the HIV-1 genome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Phenotypic properties of transmitted founder HIV-1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Role of transmitted Gag CTL polymorphisms in defining replicative capacity and early HIV-1 pathogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Modelling the course of an HIV infection: insights from ecology and evolution

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Have the explosive HIV epidemics in sub-Saharan Africa been driven by higher community viral load?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Cumulative impact of host and viral factors on HIV-1 viral-load control during early infection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Partner characteristics predicting HIV-1 set point in sexually acquired HIV-1 among African seroconverters

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Previously transmitted HIV-1 strains are preferentially selected during subsequent sexual transmissions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Exploring the complexity of the HIV-1 fitness landscape

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Rational design of vaccines to elicit broadly neutralizing antibodies to HIV-1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Origins of HIV and the AIDS pandemic

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Copy number variation of KIR genes influences HIV-1 control

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Is the virulence of HIV changing? A meta-analysis of trends in prognostic markers of HIV disease progression and transmission

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Assessing predicted HIV-1 replicative capacity in a clinical setting

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Recurrent signature patterns in HIV-1 B clade envelope glycoproteins associated with either early or chronic infections

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Prevention of HIV-1 infection with early antiretroviral therapy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

5 July 2018

Acute HIV-1 Infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Preexposure chemoprophylaxis for HIV prevention in men who have sex with men

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Phylogenetic approach reveals that virus genotype largely determines HIV set-point viral load

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Impaired replication capacity of acute/early viruses in persons who become HIV controllers

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

HIV-1 transmitting couples have similar viral load set-points in Rakai, Uganda

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

HIV RNA level in early infection is predicted by viral load in the transmission source

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Common genetic variation and the control of HIV-1 in humans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

HIV-1 viral subtype differences in the rate of CD4+ T-cell decline among HIV seroincident antiretroviral naive persons in Rakai district, Uganda

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

HIV-1 subtypes and differences in heterosexual HIV transmission among HIV-discordant couples in Rakai, Uganda

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Finding the missing heritability of complex diseases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Viral load levels measured at set-point have risen over the last decade of the HIV epidemic in the Netherlands

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Evolutionary analysis of the dynamics of viral infectious disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Virulence evolution and the trade-off hypothesis: history, current state of affairs and the future

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Has HIV evolved to induce immune pathogenesis?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Variation in HIV-1 set-point viral load: epidemiological analysis and an evolutionary hypothesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Microbial translocation is a cause of systemic immune activation in chronic HIV infection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Human immunodeficiency virus type 1 fitness is a determining factor in viral rebound and set point in chronic infection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Glancing behind virus load variation in HIV-1 infection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Immunologic and virologic status after 14 to 18 years of infection with an attenuated strain of HIV-1. A report from the Sydney Blood Bank Cohort

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

The extent of early viral replication is a critical determinant of the natural history of simian immunodeficiency virus infection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

HIV-1 Vpr suppresses immune activation and apoptosis through regulation of nuclear factor kappa B.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Short-sighted evolution and the virulence of pathogenic microorganisms

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71)

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Viral dynamics in human immunodeficiency virus type 1 infection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Coevolution of hosts and parasites

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

Long-term cultures of HTLV-III--infected T cells: a model of cytopathology of T-cell depletion in AIDS.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

HIV-1 replication is controlled at the level of T cell activation and proviral integration

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034889

AIDS prognosis based on HIV-1 RNA, CD4+ T-cell count and function: markers with reciprocal predictive value over time after seroconversion.

5 July 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1243727

Early protective effect of CCR-5 delta 32 heterozygosity on HIV-1 disease progression: relationship with viral load. The SEROCO Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1243727

HLA allele sharing and HIV type 1 viremia in seroconverting Zambians with known transmitting partners

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1243727

A dual infection/competition assay shows a correlation between ex vivo human immunodeficiency virus type 1 fitness and disease progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1243727

HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1243727

Viral dynamics in primary HIV-1 infection. Karolinska Institutet Primary HIV Infection Study Group.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1243727

Interpretation of correlations in setpoint viral load in transmitting couples

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1243727

HIV-1 transmission, by stage of infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1243727

Estimating the impact of plasma HIV-1 RNA reductions on heterosexual HIV-1 transmission risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1243727

The Relative Importance of Heredity and Environment in Determining the Piebald Pattern of Guinea-Pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1243727

The Method of Path Coefficients

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1243727

New insights into the evolutionary rate of HIV-1 at the within-host and epidemiological levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1243727

HIV RNA levels in transmission sources only weakly predict plasma viral load in recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1243727

A systems analysis of mutational effects in HIV-1 protease and reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1243727

Sexual Transmission and Propagation of SIV and HIV in Resting and Activated CD4+ T Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1243727

Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1243727

Immune Hyperactivation of HIV-1-Infected T Cells Mediated by Tat and the CD28 Pathway

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24653038

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24653038

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCIENCE.1243727

1 reference

30 July 2017

1 reference

30 July 2017

1 reference

PubMed ID

24653038