(Q34044464)

30 July 2017

title

G alpha q-containing G proteins regulate B cell selection and survival and are required to prevent B cell-dependent autoimmunity (English)

1 reference

30 July 2017

Ravi S Misra

1

1 reference

30 July 2017

Guixiu Shi

2

1 reference

30 July 2017

Miguel E Moreno-Garcia

3

1 reference

30 July 2017

Anil Thankappan

4

1 reference

30 July 2017

Michael Tighe

5

1 reference

30 July 2017

Betty Mousseau

6

1 reference

30 July 2017

Kim Kusser

7

1 reference

30 July 2017

Shirly Becker-Herman

8

1 reference

30 July 2017

Kelly L Hudkins

9

1 reference

30 July 2017

Robert Dunn

10

1 reference

30 July 2017

Marilyn R Kehry

11

1 reference

30 July 2017

Thi-Sau Migone

12

1 reference

30 July 2017

Ann Marshak-Rothstein

13

1 reference

30 July 2017

Melvin Simon

14

1 reference

30 July 2017

Troy D Randall

15

1 reference

30 July 2017

Charles E Alpers

16

1 reference

30 July 2017

Denny Liggitt

17

1 reference

30 July 2017

David J Rawlings

18

1 reference

30 July 2017

Frances E Lund

19

1 reference

30 July 2017

language of work or name

English

0 references

publication date

12 July 2010

1 reference

Journal of Experimental Medicine

30 July 2017

published in

1 reference

30 July 2017

volume

207

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30 July 2017

issue

8

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30 July 2017

page(s)

1775-1789

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Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy

30 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916136

PI3 kinase signals BCR-dependent mature B cell survival

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916136

Signalling crosstalk in B cells: managing worth and need

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916136

Heterotrimeric G proteins and apoptosis: intersecting signaling pathways leading to context dependent phenotypes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916136

The AKT axis as a therapeutic target in autoimmune diseases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916136

Fine tuning the immune response with PI3K.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916136

B cells and immunological tolerance.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916136

Renal involvement in the antiphospholipid syndrome (APS)-APS nephropathy.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916136

Tonic B cell antigen receptor signals supply an NF-kappaB substrate for prosurvival BLyS signaling.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916136

Repertoire-based selection into the marginal zone compartment during B cell development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916136

Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916136

Identification of an alternative G{alpha}q-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916136

The recirculating B cell pool contains two functionally distinct, long-lived, posttransitional, follicular B cell populations

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916136

Multistep pathogenesis of autoimmune disease.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916136

AKT/PKB signaling: navigating downstream

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916136

BAFF controls B cell metabolic fitness through a PKC beta- and Akt-dependent mechanism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916136

Galphaq expression activates EGFR and induces Akt mediated cardiomyocyte survival: dissociation from Galphaq mediated hypertrophy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916136

Characterization of marginal zone B cell precursors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916136

Cell signalling diversity of the Gqalpha family of heterotrimeric G proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916136

Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916136

Mouse models to study G-protein-mediated signaling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916136

Akt-mediated cardiomyocyte survival pathways are compromised by G alpha q-induced phosphoinositide 4,5-bisphosphate depletion

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916136

Activated Gαq Inhibits p110α Phosphatidylinositol 3-Kinase and Akt

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916136

Dual regulation of Akt/protein kinase B by heterotrimeric G protein subunits

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916136

B cell antigen receptor-induced activation of Akt promotes B cell survival and is dependent on Syk kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916136

Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916136

Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916136

Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking Galphaq

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916136

Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916136

Characterization of G-protein alpha subunits in the Gq class: expression in murine tissues and in stromal and hematopoietic cell lines

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916136

Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function

5 July 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092735

B cell developmental requirement for the G alpha i2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092735

Characterization of the GNAQ promoter and association of increased Gq expression with cardiac hypertrophy in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092735

Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092735

A functional polymorphism of the Galphaq (GNAQ) gene is associated with accelerated mortality in African-American heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092735

Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092735

The heterotrimeric G-protein alpha-subunit Galphaq regulates TCR-mediated immune responses through an Lck-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092735

Transitional B lymphocyte subsets operate as distinct checkpoints in murine splenic B cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092735

Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20092735

21 January 2018

Galphaq and its Aktions

1 reference

12 December 2020

Generation of peripheral B cells occurs via two spatially and temporally distinct pathways

1 reference

12 December 2020

Suppression of proteoglycan-induced arthritis by anti-CD20 B Cell depletion therapy is mediated by reduction in autoantibodies and CD4+ T cell reactivity

1 reference

12 December 2020

B cell depletion inhibits spontaneous autoimmune thyroiditis in NOD.H-2h4 mice

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20092735

1 reference

30 July 2017

1 reference

30 July 2017

1 reference