(Q34049636)

30 July 2017

title

Akt2 phosphorylates ezrin to trigger NHE3 translocation and activation (English)

1 reference

30 July 2017

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4

Eugene B Chang

1 reference

30 July 2017

Harn Shiue

1

1 reference

30 July 2017

Mark W Musch

series ordinal

2

1 reference

30 July 2017

Yingmin Wang

series ordinal

3

1 reference

30 July 2017

Jerrold R Turner

series ordinal

5

1 reference

30 July 2017

language of work or name

English

0 references

publication date

4 November 2004

1 reference

Journal of Biological Chemistry

30 July 2017

published in

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30 July 2017

volume

280

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30 July 2017

issue

2

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30 July 2017

page(s)

1688-1695

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describes a project that uses

30 July 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC1237052/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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The lateral mobility of NHE3 on the apical membrane of renal epithelial OK cells is limited by the PDZ domain proteins NHERF1/2, but is dependent on an intact actin cytoskeleton as determined by FRAP.

28 July 2018

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28 July 2018

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28 July 2018

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The NHE1 Na+/H+ exchanger recruits ezrin/radixin/moesin proteins to regulate Akt-dependent cell survival.

28 July 2018

1 reference

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Akt kinase activation blocks apoptosis in intestinal epithelial cells by inhibiting caspase-3 after polyamine depletion

28 July 2018

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28 July 2018

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Phosphoinositide binding and phosphorylation act sequentially in the activation mechanism of ezrin

28 July 2018

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Cyclic AMP-dependent protein kinase phosphorylates merlin at serine 518 independently of p21-activated kinase and promotes merlin-ezrin heterodimerization

28 July 2018

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28 July 2018

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28 July 2018

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Ca2+-dependent inhibition of NHE3 requires PKC alpha which binds to E3KARP to decrease surface NHE3 containing plasma membrane complexes

28 July 2018

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Lysophosphatidic acid stimulates brush border Na+/H+ exchanger 3 (NHE3) activity by increasing its exocytosis by an NHE3 kinase A regulatory protein-dependent mechanism

28 July 2018

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NHERF-1 uniquely transduces the cAMP signals that inhibit sodium-hydrogen exchange in mouse renal apical membranes

28 July 2018

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28 July 2018

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28 July 2018

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Rho-dependent and -independent activation mechanisms of ezrin/radixin/moesin proteins: an essential role for polyphosphoinositides in vivo.

28 July 2018

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ERM proteins and NF2 tumor suppressor: the Yin and Yang of cortical actin organization and cell growth signaling

28 July 2018

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Na+-H+ exchanger 3 (NHE3) is present in lipid rafts in the rabbit ileal brush border: a role for rafts in trafficking and rapid stimulation of NHE3

28 July 2018

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Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton

28 July 2018

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Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237052

Ezrin binding domain-deficient NHERF attenuates cAMP-mediated inhibition of Na(+)/H(+) exchange in OK cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237052

Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motility

28 July 2018

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Constitutively active phosphatidylinositol 3-kinase and AKT are sufficient to stimulate the epithelial Na+/H+ exchanger 3.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237052

Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10

28 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237052

Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Dbl oncogenes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237052

Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237052

Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237052

Activation of ERM proteins in vivo by Rho involves phosphatidyl-inositol 4-phosphate 5-kinase and not ROCK kinases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237052

The role of NHERF and E3KARP in the cAMP-mediated inhibition of NHE3.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237052

NHE3 kinase A regulatory protein E3KARP binds the epithelial brush border Na+/H+ exchanger NHE3 and the cytoskeletal protein ezrin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237052

Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+ exchanger

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237052

Association of the myosin-binding subunit of myosin phosphatase and moesin: dual regulation of moesin phosphorylation by Rho-associated kinase and myosin phosphatase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237052

RhoA-dependent phosphorylation and relocalization of ERM proteins into apical membrane/actin protrusions in fibroblasts

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237052

Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237052

Mechanism of activation of protein kinase B by insulin and IGF-1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237052

Carboxy-terminal vesicular stomatitis virus G protein-tagged intestinal Na+-dependent glucose cotransporter (SGLT1): maintenance of surface expression and global transport function with selective perturbation of transport kinetics and polarized expr

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237052

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237052

Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein family

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237052

Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237052

Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association

28 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409471200

Morphogenic effects of ezrin require a phosphorylation-induced transition from oligomers to monomers at the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409471200

Moesin functions antagonistically to the Rho pathway to maintain epithelial integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409471200

Ezrin regulates NHE3 translocation and activation after Na+-glucose cotransport.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409471200

Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409471200

A dileucine motif targets the sulfate anion transporter sat-1 to the basolateral membrane in renal cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409471200

Inhibition and redistribution of NHE3, the apical Na+/H+ exchanger, by Clostridium difficile toxin B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409471200

Role of p38 MAPK and MAPKAPK-2 in angiotensin II-induced Akt activation in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409471200

An inhibitor of p38 mitogen-activated protein kinase prevents insulin-stimulated glucose transport but not glucose transporter translocation in 3T3-L1 adipocytes and L6 myotubes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409471200

Differential effects of phosphatidylinositol 3-kinase inhibition on intracellular signals regulating GLUT4 translocation and glucose transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409471200

Lipid Raft targeting of the TC10 amino terminal domain is responsible for disruption of adipocyte cortical actin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409471200

Requirement of the epidermal growth factor receptor in renal epithelial cell proliferation and migration

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237052

NHE3-dependent cytoplasmic alkalinization is triggered by Na(+)-glucose cotransport in intestinal epithelia

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237052

Phosphoinositide 3-kinase is required for insulin-induced but not for growth hormone- or hyperosmolarity-induced glucose uptake in 3T3-L1 adipocytes

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1237052

Protein kinase C-theta phosphorylation of moesin in the actin-binding sequence

28 October 2018

1 reference

12 December 2020

RhoA and rho kinase regulate the epithelial Na+/H+ exchanger NHE3. Role of myosin light chain phosphorylation

1 reference

12 December 2020

Cutting edge: negative regulation of immune synapse formation by anchoring lipid raft to cytoskeleton through Cbp-EBP50-ERM assembly

1 reference

12 December 2020

The apical Na(+)/H(+) exchanger isoform NHE3 is regulated by the actin cytoskeleton

1 reference

12 December 2020

Soluble ezrin purified from placenta exists as stable monomers and elongated dimers with masked C-terminal ezrin-radixin-moesin association domains

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M409471200

1 reference

30 July 2017

1 reference

30 July 2017

1 reference