(Q34049938)

30 July 2017

title

Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index (English)

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25

Gail P Jarvik

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Jyotishman Pathak

16

Jyotishman Pathak

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Jonathan D Mosley

6

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Sarah Pendergrass

Sarah A Pendergrass

13

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Paul K. Crane

Paul K Crane

12

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Gerard Tromp

Gerard Tromp

22

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Catherine A. McCarty

Catherine A McCarty

28

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Erwin Böttinger

31

Erwin Bottinger

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14

Marylyn D Ritchie

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15

Dana C Crawford

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7

Lisa Bastarache

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11

Lucia A Hindorff

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Christopher G Chute

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8

Todd L Edwards

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35

Joshua C Denny

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34

Dan M Roden

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23

Marc S Williams

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5

Robert J Carroll

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32

Rex Chisholm

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19

David R Crosslin

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30

Iftikhar J Kullo

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17

Suzette J Bielinski

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18

David S Carrell

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27

Murray H Brilliant

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9

Scott J Hebbring

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2

Julie R Field

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26

Peggy L Peissig

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3

Yuki Bradford

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20

David H Ledbetter

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1

Robert M Cronin

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Christian M Shaffer

4

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Simon Lin

10

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David J Carey

21

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Eric B Larson

24

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Maureen E Smith

33

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30 July 2017

publication date

5 August 2014

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30 July 2017

published in

Frontiers in Genetics

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30 July 2017

volume

5

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30 July 2017

page(s)

250

1 reference

describes a project that uses

30 July 2017

ggplot2

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pmc&rettype=xml&id=4134007

ggplot2

2 references

10 June 2022

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

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R PheWAS: data analysis and plotting tools for phenome-wide association studies in the R environment

1 reference

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Obesity-associated variants within FTO form long-range functional connections with IRX3

28 July 2018

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Associations of genetic variants in/near body mass index-associated genes with type 2 diabetes: a systematic meta-analysis

28 July 2018

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28 July 2018

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Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data

28 July 2018

1 reference

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A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects

28 July 2018

1 reference

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Association of the FTO obesity risk variant rs8050136 with percentage of energy intake from fat in multiple racial/ethnic populations: the PAGE study

28 July 2018

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Pleiotropy in complex traits: challenges and strategies

28 July 2018

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28 July 2018

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Genetic variants that confer resistance to malaria are associated with red blood cell traits in African-Americans: an electronic medical record-based genome-wide association study

28 July 2018

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Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk

28 July 2018

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A PheWAS approach in studying HLA-DRB1*1501.

28 July 2018

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Genetic variation associated with circulating monocyte count in the eMERGE Network

28 July 2018

1 reference

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Mining the human phenome using semantic web technologies: a case study for Type 2 Diabetes

28 July 2018

1 reference

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Statistical and biological gene-lifestyle interactions of MC4R and FTO with diet and physical activity on obesity: new effects on alcohol consumption

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

Genetic variants in the Fat and Obesity Associated (FTO) gene and risk of Alzheimer's disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

FTO at rs9939609, food responsiveness, emotional control and symptoms of ADHD in preschool children

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

The impact of intronic single nucleotide polymorphisms and ethnic diversity for studies on the obesity gene FTO.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

A model of developmental evolution: selection, pleiotropy and compensation.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

Abundant pleiotropy in human complex diseases and traits.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

Complement receptor 1 gene variants are associated with erythrocyte sedimentation rate

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

Mapping clinical phenotype data elements to standardized metadata repositories and controlled terminologies: the eMERGE Network experience

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

The use of phenome-wide association studies (PheWAS) for exploration of novel genotype-phenotype relationships and pleiotropy discovery

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

FTO, type 2 diabetes, and weight gain throughout adult life: a meta-analysis of 41,504 subjects from the Scandinavian HUNT, MDC, and MPP studies

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

The obesity-associated polymorphisms FTO rs9939609 and MC4R rs17782313 and endometrial cancer risk in non-Hispanic white women

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

The pleiotropic structure of the genotype-phenotype map: the evolvability of complex organisms.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

An FTO variant is associated with Type 2 diabetes in South Asian populations after accounting for body mass index and waist circumference

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

Quality control procedures for genome-wide association studies

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

Progress and promise of genome-wide association studies for human complex trait genetics

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

A map of human genome variation from population-scale sequencing

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

The origins and evolution of genetic disease risk in modern humans

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

Genetic studies of common types of obesity: a critique of the current use of phenotypes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

Regulation and function of FTO mRNA expression in human skeletal muscle and subcutaneous adipose tissue

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

Avoiding the high Bonferroni penalty in genome-wide association studies

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

Comparison of body mass index with waist circumference, waist-to-hip ratio, and waist-to-stature ratio as a predictor of hypertension incidence in Mauritius

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

Regulation of Fto/Ftm gene expression in mice and humans

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

PLINK: a tool set for whole-genome association and population-based linkage analyses

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

A new multipoint method for genome-wide association studies by imputation of genotypes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

Comparison of body mass index, waist circumference, and waist/hip ratio in predicting incident diabetes: a meta-analysis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

Principal components analysis corrects for stratification in genome-wide association studies

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

Failure of ICD-9-CM codes to identify patients with comorbid chronic kidney disease in diabetes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

Early life factors and incidence of proliferative benign breast disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

Risk factors for benign proliferative breast disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

Comparison of ICD-9-based, retrospective, and prospective assessments of perioperative complications: assessment of accuracy in reporting

28 July 2018

1 reference

https://api.crossref.org/works/10.3389%2FFGENE.2014.00250

PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFGENE.2014.00250

Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFGENE.2014.00250

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFGENE.2014.00250

Fine Mapping and Identification of BMI Loci in African Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFGENE.2014.00250

The FTO gene and obesity in a large Eastern European population sample: the HAPIEE study

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFGENE.2014.00250

Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFGENE.2014.00250

Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFGENE.2014.00250

Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein (CBP)-associated factor and CBP

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFGENE.2014.00250

BMI compared with central obesity indicators as a predictor of diabetes incidence in Mauritius

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFGENE.2014.00250

Phenome-wide association study (PheWAS) for detection of pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFGENE.2014.00250

Inverse association of the obesity predisposing FTO rs9939609 genotype with alcohol consumption and risk for alcohol dependence.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

Inference of population structure using multilocus genotype data

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4134007

Meta-analysis Added Power to Identify Variants in FTO Associated With Type 2 Diabetes and Obesity in the Asian Population

28 October 2018

1 reference

https://api.crossref.org/works/10.3389%2FFGENE.2014.00250

Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFGENE.2014.00250

Dietary and other risk factors in women having fibrocystic breast conditions with and without concurrent breast cancer: a nested case-control study in Shanghai, China

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25177340

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

FTO polymorphisms are associated with obesity but not with diabetes in East Asian populations: a meta-analysis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25177340

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3389/FGENE.2014.00250

1 reference

release_unbwjqmhwja3vpzokslmkmbdpm

30 July 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/unbwjqmhwja3vpzokslmkmbdpm

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

4134007

1 reference

30 July 2017

1 reference