(Q34059822)

English

Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines (English)

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

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protein structure

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object named as

Peter J Brown

18

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object named as

Ajit Jadhav

13

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Cheryl Arrowsmith

object named as

Cheryl H Arrowsmith

16

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Gregory A Wasney

6

object named as

Gregory A Wasney

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

19

object named as

Anton Simeonov

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30 July 2017

author name string

Feng Liu

1

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Europe PubMed Central

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30 July 2017

Xin Chen

2

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30 July 2017

Abdellah Allali-Hassani

3

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Europe PubMed Central

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30 July 2017

Amy M Quinn

4

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30 July 2017

Tim J Wigle

5

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Europe PubMed Central

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30 July 2017

Aiping Dong

7

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30 July 2017

Guillermo Senisterra

8

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30 July 2017

Irene Chau

9

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30 July 2017

Alena Siarheyeva

10

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30 July 2017

Jacqueline L Norris

11

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Europe PubMed Central

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30 July 2017

Dmitri B Kireev

12

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Europe PubMed Central

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30 July 2017

J Martin Herold

14

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30 July 2017

William P Janzen

15

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30 July 2017

Stephen V Frye

17

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30 July 2017

Masoud Vedadi

20

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30 July 2017

Jian Jin

21

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30 July 2017

language of work or name

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publication date

1 August 2010

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Europe PubMed Central

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30 July 2017

Journal of Medicinal Chemistry

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Europe PubMed Central

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30 July 2017

53

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Europe PubMed Central

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30 July 2017

15

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Europe PubMed Central

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30 July 2017

5844-5857

1 reference

Europe PubMed Central

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30 July 2017

Accessing protein methyltransferase and demethylase enzymology using microfluidic capillary electrophoresis

1 reference

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5 July 2018

A chemiluminescence-based method for identification of histone lysine methyltransferase inhibitors

1 reference

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Involvement of histone H3 lysine 9 (H3K9) methyltransferase G9a in the maintenance of HIV-1 latency and its reactivation by BIX01294.

1 reference

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The art of the chemical probe

1 reference

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G9a and Glp methylate lysine 373 in the tumor suppressor p53

1 reference

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A miniaturized screen for inhibitors of Jumonji histone demethylases

1 reference

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Essential role of the histone methyltransferase G9a in cocaine-induced plasticity

1 reference

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Control of cognition and adaptive behavior by the GLP/G9a epigenetic suppressor complex

1 reference

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5 July 2018

Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920043

5 July 2018

The emerging therapeutic potential of histone methyltransferase and demethylase inhibitors

1 reference

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Protein methyltransferases as a target class for drug discovery

1 reference

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A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity

1 reference

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5 July 2018

Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920043

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Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds

1 reference

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Chemical probes for histone-modifying enzymes

1 reference

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5 July 2018

Cancer treatment of the future: inhibitors of histone methyltransferases

1 reference

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5 July 2018

Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-kappaB-dependent inflammatory genes. Relevance to diabetes and inflammation

1 reference

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5 July 2018

Downregulation of histone H3 lysine 9 methyltransferase G9a induces centrosome disruption and chromosome instability in cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920043

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Epigenetics in cancer

1 reference

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Role of histone modifications in defining chromatin structure and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920043

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Chromatin-modifying proteins in cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920043

5 July 2018

L3MBTL1 recognition of mono- and dimethylated histones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920043

5 July 2018

The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920043

5 July 2018

Chromatin modifications and their function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920043

5 July 2018

The mammalian epigenome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920043

5 July 2018

Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920043

5 July 2018

Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination

1 reference

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Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state

1 reference

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The diverse functions of histone lysine methylation

1 reference

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DNA methyltransferase inhibitors and the development of epigenetic cancer therapies

1 reference

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G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis

1 reference

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Translating the Histone Code

1 reference

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Regulation of chromatin structure by site-specific histone H3 methyltransferases

1 reference

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The language of covalent histone modifications

1 reference

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Kinetics of the reversible inhibition of enzyme-catalysed reactions by tight-binding inhibitors

1 reference

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17 The kinetics of reversible tight-binding inhibition

1 reference

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Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9.

1 reference

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A coupled fluorescent assay for histone methyltransferases

1 reference

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A combined chemical and genetic approach for the generation of induced pluripotent stem cells

1 reference

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12 December 2020

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10.1021/JM100478Y

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PMC publication ID

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Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

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