(Q34060224)

30 July 2017

title

ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice (English)

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30 July 2017

5

Ku-Lung Hsu

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30 July 2017

16

Benjamin F Cravatt

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30 July 2017

Alipi V Naydenov

1

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30 July 2017

Eric A Horne

2

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30 July 2017

Christine S Cheah

3

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30 July 2017

Katie Swinney

4

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30 July 2017

Jessica K Cao

6

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30 July 2017

William Marrs

7

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30 July 2017

Jacqueline L Blankman

8

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30 July 2017

Sarah Tu

9

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30 July 2017

Allison E Cherry

10

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30 July 2017

Susan Fung

11

1 reference

30 July 2017

Andy Wen

12

1 reference

30 July 2017

Weiwei Li

13

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30 July 2017

Michael S Saporito

14

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30 July 2017

Dana E Selley

15

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30 July 2017

John C Oakley

17

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30 July 2017

Nephi Stella

18

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30 July 2017

language of work or name

English

0 references

publication date

1 July 2014

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30 July 2017

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30 July 2017

volume

83

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30 July 2017

issue

2

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30 July 2017

page(s)

361-371

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describes a project that uses

30 July 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4136499/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6)

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Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis

5 July 2018

1 reference

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The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome

5 July 2018

1 reference

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Molecular analysis of the site for 2-arachidonylglycerol (2-AG) on the β₂ subunit of GABA(A) receptors

5 July 2018

1 reference

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Sudden unexpected death in a mouse model of Dravet syndrome

5 July 2018

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5 July 2018

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Downregulation of cannabinoid receptor 1 from neuropeptide Y interneurons in the basal ganglia of patients with Huntington's disease and mouse models.

5 July 2018

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Seizures in juvenile Huntington's disease: frequency and characterization in a multicenter cohort

5 July 2018

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DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses

5 July 2018

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Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12)

5 July 2018

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Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome

5 July 2018

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5 July 2018

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R6/2 Huntington's disease mice develop early and progressive abnormal brain metabolism and seizures

5 July 2018

1 reference

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Multiple functions of endocannabinoid signaling in the brain.

5 July 2018

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The major central endocannabinoid directly acts at GABA(A) receptors

5 July 2018

1 reference

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Dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons.

5 July 2018

1 reference

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Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening

5 July 2018

1 reference

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Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

5 July 2018

1 reference

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Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy.

5 July 2018

1 reference

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The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

5 July 2018

1 reference

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Key factors in the discovery and development of new antiepileptic drugs

5 July 2018

1 reference

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Prolonged exposure to WIN55,212-2 causes downregulation of the CB1 receptor and the development of tolerance to its anticonvulsant effects in the hippocampal neuronal culture model of acquired epilepsy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

Altered CB1 receptor and endocannabinoid levels precede motor symptom onset in a transgenic mouse model of Huntington's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

Temperature- and age-dependent seizures in a mouse model of severe myoclonic epilepsy in infancy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

High-frequency oscillations: what is normal and what is not?

5 July 2018

1 reference

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Enzymatic pathways that regulate endocannabinoid signaling in the nervous system

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol

5 July 2018

1 reference

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Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex

5 July 2018

1 reference

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Prevention of plasticity of endocannabinoid signaling inhibits persistent limbic hyperexcitability caused by developmental seizures.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

Discovery of antiepileptic drugs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

CB1 cannabinoid receptors and on-demand defense against excitotoxicity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

Preclinical development of antiepileptic drugs: past, present, and future directions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

Early identification of refractory epilepsy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

Role of the Y5 neuropeptide Y receptor in limbic seizures

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

Neuropeptide Y: emerging evidence for a functional role in seizure modulation.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

Hippocampal and entorhinal cortex high-frequency oscillations (100--500 Hz) in human epileptic brain and in kainic acid--treated rats with chronic seizures

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

Knock-out mice reveal a critical antiepileptic role for neuropeptide Y.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

A second endogenous cannabinoid that modulates long-term potentiation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

Neuropeptide Y inhibits hippocampal seizures and wet dog shakes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

Formation and inactivation of endogenous cannabinoid anandamide in central neurons

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

Modification of seizure activity by electrical stimulation. II. Motor seizure

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

Neuropeptide Y action in the rat hippocampal slice: site and mechanism of presynaptic inhibition.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

Inverse relationship of cannabimimetic (R+)WIN 55, 212 on behavior and seizure threshold during the juvenile period

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

Abnormal sensitivity to cannabinoid receptor stimulation might contribute to altered gamma-aminobutyric acid transmission in the striatum of R6/2 Huntington's disease mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

Requirement of alpha5-GABAA receptors for the development of tolerance to the sedative action of diazepam in mice.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

Increased Seizure Susceptibility and Proconvulsant Activity of Anandamide in Mice Lacking Fatty Acid Amide Hydrolase

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

The endogenous cannabinoid system controls extinction of aversive memories

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

Receptor-dependent formation of endogenous cannabinoids in cortical neurons

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

Mapping loci for pentylenetetrazol-induced seizure susceptibility in mice.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

Loss of cannabinoid receptors in the substantia nigra in Huntington's disease.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136499

Repeated administration of subconvulsant doses of GABA antagonist drugs

28 October 2018

1 reference

12 December 2020

Enhanced neuropeptide Y release in the hippocampus is associated with chronic seizure susceptibility in kainic acid treated rats

1 reference

12 December 2020

Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y

1 reference

12 December 2020

Powerful inhibition of kainic acid seizures by neuropeptide Y via Y5-like receptors

1 reference

12 December 2020

Endocannabinoid signaling in the brain: biosynthetic mechanisms in the limelight

1 reference

12 December 2020

10.1016/J.NEURON.2014.06.030

Identifiers

DOI

1 reference

30 July 2017

1 reference

30 July 2017

1 reference