(Q34079471)

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Dietary procyanidins enhance transcriptional activity of bile acid-activated FXR in vitro and reduce triglyceridemia in vivo in a FXR-dependent manner.

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19496086%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Dietary procyanidins enhance transcriptional activity of bile acid-activated FXR in vitro and reduce triglyceridemia in vivo in a FXR-dependent manner (English)

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30 January 2020

Marie-Louise Ricketts

2

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30 January 2020

Josep M Del Bas

1

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30 January 2020

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30 January 2020

Josepa Salvadó

7

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30 January 2020

8

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30 January 2020

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30 January 2020

11

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30 January 2020

13

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30 January 2020

Juan Fernandez-Larrea

12

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Juan Fernandez-Larrea

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30 January 2020

Montserrat Vaqué

3

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Montserrat Vaqué

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30 January 2020

5

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Helena Quesada

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30 January 2020

author name string

Esther Sala

4

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30 January 2020

David D Moore

10

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30 January 2020

publication date

1 July 2009

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30 January 2020

Molecular Nutrition and Food Research

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30 January 2020

53

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30 January 2020

7

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30 January 2020

805-814

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19496086%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

Dietary procyanidins lower triglyceride levels signaling through the nuclear receptor small heterodimer partner.

1 reference

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5 July 2018

SREBPs: the crossroads of physiological and pathological lipid homeostasis

1 reference

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5 July 2018

FXR, a target for different diseases

1 reference

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5 July 2018

Phenolics from purple grape, apple, purple grape juice and apple juice prevent early atherosclerosis induced by an atherogenic diet in hamsters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

5 July 2018

FXR signaling in metabolic disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

5 July 2018

Structure and function of the atypical orphan nuclear receptor small heterodimer partner

1 reference

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5 July 2018

Bile acids, farnesoid X receptor, atherosclerosis and metabolic control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

5 July 2018

FXR: a promising target for the metabolic syndrome?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

5 July 2018

Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

5 July 2018

Applications for protein sequence-function evolution data: mRNA/protein expression analysis and coding SNP scoring tools

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

5 July 2018

FXR, a multipurpose nuclear receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

5 July 2018

Concentrated red grape juice exerts antioxidant, hypolipidemic, and antiinflammatory effects in both hemodialysis patients and healthy subjects.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

5 July 2018

Red grape juice polyphenols alter cholesterol homeostasis and increase LDL-receptor activity in human cells in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

5 July 2018

Endocrine functions of bile acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

5 July 2018

Is apolipoprotein A5 a novel regulator of triglyceride-rich lipoproteins?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

5 July 2018

Apolipoprotein B: a clinically important apolipoprotein which assembles atherogenic lipoproteins and promotes the development of atherosclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

5 July 2018

Xanthohumol, the chalcone from beer hops (Humulus lupulus L.), is the ligand for farnesoid X receptor and ameliorates lipid and glucose metabolism in KK-A(y) mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

5 July 2018

The absorption, metabolism and excretion of flavan-3-ols and procyanidins following the ingestion of a grape seed extract by rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

5 July 2018

Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

5 July 2018

The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

5 July 2018

Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

5 July 2018

Dietary proanthocyanidins: occurrence, dietary intake, bioavailability, and protection against cardiovascular disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

5 July 2018

SREBP transcription factors: master regulators of lipid homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

5 July 2018

Apple procyanidins decrease cholesterol esterification and lipoprotein secretion in Caco-2/TC7 enterocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

5 July 2018

Vascular effects of wine polyphenols

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

5 July 2018

The nuclear bile acid receptor FXR is activated by PGC-1alpha in a ligand-dependent manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

5 July 2018

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

5 July 2018

Concentrations of proanthocyanidins in common foods and estimations of normal consumption

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

5 July 2018

The farnesoid X receptor controls gene expression in a ligand- and promoter-selective fashion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

5 July 2018

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

5 July 2018

PANTHER: a library of protein families and subfamilies indexed by function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

5 July 2018

A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

5 July 2018

Nuclear receptor ligands and cofactor recruitment: is there a coactivator "on deck"?

1 reference

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5 July 2018

Red wine polyphenolics increase LDL receptor expression and activity and suppress the secretion of ApoB100 from human HepG2 cells

1 reference

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5 July 2018

Insulin and sterol-regulatory element-binding protein-1c (SREBP-1C) regulation of gene expression in 3T3-L1 adipocytes. Identification of CCAAT/enhancer-binding protein beta as an SREBP-1C target

1 reference

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5 July 2018

Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy status

1 reference

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5 July 2018

Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

5 July 2018

Sterol regulatory element-binding proteins induce an entire pathway of cholesterol synthesis

1 reference

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5 July 2018

Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

5 July 2018

Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

5 July 2018

Activation of the orphan receptor RIP14 by retinoids

1 reference

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5 July 2018

Dietary grape seed tannins affect lipoproteins, lipoprotein lipases and tissue lipids in rats fed hypercholesterolemic diets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

28 October 2018

Grape seed procyanidins improve atherosclerotic risk index and induce liver CYP7A1 and SHP expression in healthy rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

28 October 2018

Phenolics from commercialized grape extracts prevent early atherosclerotic lesions in hamsters by mechanisms other than antioxidant effect

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

28 October 2018

ApoAV reduces plasma triglycerides by inhibiting very low density lipoprotein-triglyceride (VLDL-TG) production and stimulating lipoprotein lipase-mediated VLDL-TG hydrolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

28 October 2018

Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

28 October 2018

A natural product that lowers cholesterol as an antagonist ligand for FXR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

28 October 2018

Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4142053

28 October 2018

Oligomeric procyanidins in apple polyphenol are main active components for inhibition of pancreatic lipase and triglyceride absorption

1 reference

https://pubmed.ncbi.nlm.nih.gov/19496086

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The farnesoid X-activated receptor mediates bile acid activation of phospholipid transfer protein gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/19496086

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TRRAP as a hepatic coactivator of LXR and FXR function

1 reference

https://pubmed.ncbi.nlm.nih.gov/19496086

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apple procyanidin oligomers absorption in rats after oral administration: analysis of procyanidins in plasma using the porter method and high-performance liquid chromatography/tandem mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/19496086

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/MNFR.200800364

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19496086%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19496086%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19496086%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

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