(Q34096649)

31 July 2017

Coupling mammalian cell surface display with somatic hypermutation for the discovery and maturation of human antibodies (English)

1 reference

31 July 2017

1 reference

Peter M Bowers

1

1 reference

31 July 2017

Robert A Horlick

2

1 reference

31 July 2017

Tamlyn Y Neben

3

1 reference

31 July 2017

Rachelle M Toobian

4

1 reference

31 July 2017

Geoffrey L Tomlinson

5

1 reference

31 July 2017

Jennifer L Dalton

6

1 reference

31 July 2017

Heather A Jones

7

1 reference

31 July 2017

Andy Chen

8

1 reference

31 July 2017

Laurence Altobell

9

1 reference

31 July 2017

Xue Zhang

10

1 reference

31 July 2017

John L Macomber

11

1 reference

31 July 2017

Irina P Krapf

12

1 reference

31 July 2017

Betty F Wu

13

1 reference

31 July 2017

Audrey McConnell

14

1 reference

31 July 2017

Betty Chau

15

1 reference

31 July 2017

Trevin Holland

16

1 reference

31 July 2017

Ashley D Berkebile

17

1 reference

31 July 2017

Steven S Neben

18

1 reference

31 July 2017

William J Boyle

19

1 reference

31 July 2017

David J King

20

1 reference

31 July 2017

language of work or name

English

0 references

publication date

7 December 2011

1 reference

Proceedings of the National Academy of Sciences of the United States of America

31 July 2017

1 reference

31 July 2017

108

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31 July 2017

20455-20460

1 reference

31 July 2017

51

1 reference

Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

31 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

Antagonism of nerve growth factor-TrkA signaling and the relief of pain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

An Insertion Mutation That Distorts Antibody Binding Site Architecture Enhances Function of a Human Antibody

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

Development of a novel mammalian cell surface antibody display platform

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

AID and somatic hypermutation.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

Generation of stable monoclonal antibody-producing B cell receptor-positive human memory B cells by genetic programming

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

A coming-of-age story: activation-induced cytidine deaminase turns 10.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

High-throughput sequencing of the zebrafish antibody repertoire

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

Isolation of human monoclonal antibodies by mammalian cell display

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

Human monoclonal antibodies by immortalization of memory B cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

Humanization of antibodies.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

AID-initiated purposeful mutations in immunoglobulin genes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

An ex vivo method for rapid generation of monoclonal antibodies (ADLib system).

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

Codon insertion and deletion functions as a somatic diversification mechanism in human antibody repertoires

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

Potent antibody therapeutics by design

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

Darwinian evolution can follow only very few mutational paths to fitter proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

Human antibodies from transgenic animals

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

Selecting and screening recombinant antibody libraries

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

Rapid generation of specific antibodies by enhanced homologous recombination

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

Intricate targeting of immunoglobulin somatic hypermutation maximizes the efficiency of affinity maturation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

The evolutionary and structural 'logic' of antigen receptor diversity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

Directed molecular evolution by somatic hypermutation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

Diversification of the Ig variable region gene repertoire of synovial B lymphocytes by nucleotide insertion and deletion

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

Generation and iterative affinity maturation of antibodies in vitro using hypermutating B-cell lines

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

Somatic hypermutation of the AID transgene in B and non-B cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

Combinatorial gene expression using multiple episomal vectors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

The creation of diversity in the human immunoglobulin V(lambda) repertoire

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

Targeting vectors for intracellular immunisation.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

Sequence and evolution of the human germline V lambda repertoire

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

The structure of an antigenic determinant in a protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

Expression of a foreign gene in a line of transgenic mice is modulated by a chromosomal position effect

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251138

Analysis of 6912 unselected somatic hypermutations in human VDJ rearrangements reveals lack of strand specificity and correlation between phase II substitution rates and distance to the nearest 3' activation-induced cytidine deaminase target.

5 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1114010108

Generation of high-affinity human antibodies by combining donor-derived and synthetic complementarity-determining-region diversity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1114010108

Gene segments encoding transmembrane carboxyl termini of immunoglobulin gamma chains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1114010108

Nerve growth factor mediates hyperalgesia and cachexia in auto-immune arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1114010108

Tanezumab for the treatment of pain from osteoarthritis of the knee.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1114010108

Somatic insertions and deletions shape the human antibody repertoire.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1114010108

21 January 2018

Identifiers

DOI

10.1073/PNAS.1114010108

1 reference

31 July 2017

0 references

1 reference

31 July 2017

1 reference