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AID and somatic hypermutation.
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1 reference
stated in
Europe PubMed Central
PMC publication ID
2954419
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20510733%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 February 2020
review article
1 reference
stated in
Europe PubMed Central
title
AID and somatic hypermutation
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
2954419
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20510733%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 February 2020
author
Robert W. Maul
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
2954419
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20510733%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 February 2020
author name string
Patricia J Gearhart
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
2954419
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20510733%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 February 2020
publication date
1 January 2010
1 reference
stated in
Europe PubMed Central
PMC publication ID
2954419
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20510733%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 February 2020
published in
Advances in Immunology
1 reference
stated in
Europe PubMed Central
PMC publication ID
2954419
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20510733%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 February 2020
volume
105
1 reference
stated in
Europe PubMed Central
PMC publication ID
2954419
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20510733%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 February 2020
page(s)
159-191
1 reference
stated in
Europe PubMed Central
PMC publication ID
2954419
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20510733%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 February 2020
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Interference of mismatch and base excision repair during the processing of adjacent U/G mispairs may play a key role in somatic hypermutation
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Pol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability
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Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination.
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Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice
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Estrogen directly activates AID transcription and function
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A cis-acting diversification activator both necessary and sufficient for AID-mediated hypermutation
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Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression
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Analysis of intergenic transcription and histone modification across the human immunoglobulin heavy-chain locus
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Transcriptional pausing and stalling causes multiple clustered mutations by human activation-induced deaminase
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miR-181b negatively regulates activation-induced cytidine deaminase in B cells
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Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1
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5 July 2018
Proteasomal degradation restricts the nuclear lifespan of AID
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5 July 2018
MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation
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5 July 2018
The Downstream Transcriptional Enhancer, Ed, positively regulates mouse Ig kappa gene expression and somatic hypermutation
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5 July 2018
MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
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5 July 2018
DNA polymerases in adaptive immunity
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5 July 2018
Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions
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5 July 2018
G4-forming sequences in the non-transcribed DNA strand pose blocks to T7 RNA polymerase and mammalian RNA polymerase II.
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5 July 2018
Cutting edge: a cis-acting DNA element targets AID-mediated sequence diversification to the chicken Ig light chain gene locus
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5 July 2018
B-cell receptor activation inhibits AID expression through calmodulin inhibition of E-proteins
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5 July 2018
Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA.
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5 July 2018
Dependence of antibody gene diversification on uracil excision.
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5 July 2018
microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells
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5 July 2018
APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination.
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5 July 2018
Activation-induced deaminase-mediated class switch recombination is blocked by anti-IgM signaling in a phosphatidylinositol 3-kinase-dependent fashion
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5 July 2018
Role of activation-induced deaminase protein kinase A phosphorylation sites in Ig gene conversion and somatic hypermutation
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5 July 2018
A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification
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5 July 2018
DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
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5 July 2018
Sequence dependence of chromosomal R-loops at the immunoglobulin heavy-chain Smu class switch region
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
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5 July 2018
The role of activation-induced deaminase in antibody diversification and chromosome translocations
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
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5 July 2018
Regulation of the germinal center response by microRNA-155
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
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5 July 2018
Regulation of AID expression in the immune response
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
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5 July 2018
Nucleotide excision repair in an immunoglobulin variable gene is less efficient than in a housekeeping gene
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
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5 July 2018
Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
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5 July 2018
DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
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5 July 2018
Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
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5 July 2018
A role for PCNA ubiquitination in immunoglobulin hypermutation
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
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5 July 2018
Somatic hypermutation and class switch recombination in Msh6(-/-)Ung(-/-) double-knockout mice
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
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5 July 2018
The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
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5 July 2018
Absence of DNA polymerase theta results in decreased somatic hypermutation frequency and altered mutation patterns in Ig genes
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
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5 July 2018
Involvement of Rad18 in somatic hypermutation
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
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5 July 2018
Targeting of somatic hypermutation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
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5 July 2018
E2A expression stimulates Ig hypermutation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
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5 July 2018
Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
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5 July 2018
The mismatch repair protein Msh6 influences the in vivo AID targeting to the Ig locus
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
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5 July 2018
Downstream boundary of chromosomal R-loops at murine switch regions: implications for the mechanism of class switch recombination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Negative regulation of activation-induced cytidine deaminase in B cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Normal hypermutation in antibody genes from congenic mice defective for DNA polymerase iota.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
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5 July 2018
AID-dependent histone acetylation is detected in immunoglobulin S regions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Uracil DNA glycosylase disruption blocks Ig gene conversion and induces transition mutations
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
The catalytic activity of REV1 is employed during immunoglobulin gene diversification in DT40.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Elucidation of IgH intronic enhancer functions via germ-line deletion
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
DNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Inducible DNA breaks in Ig S regions are dependent on AID and UNG
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Identification of a ubiquitously active promoter of the murine activation-induced cytidine deaminase (AICDA) gene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
AID to overcome the limitations of genomic information
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Normal immunoglobulin gene somatic hypermutation in Pol kappa-Pol iota double-deficient mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Differential regulation of histone acetylation and generation of mutations in switch regions is associated with Ig class switching
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Replication protein A interacts with AID to promote deamination of somatic hypermutation targets
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
A role for Msh6 but not Msh3 in somatic hypermutation and class switch recombination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Activation-induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaks
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Absence of DNA polymerase eta reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID-mediated deoxycytidine deamination.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
DNA polymerase eta is involved in hypermutation occurring during immunoglobulin class switch recombination.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
The balance between Pax5 and Id2 activities is the key to AID gene expression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
AID mediates hypermutation by deaminating single stranded DNA.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Mlh1 Can Function in Antibody Class Switch Recombination Independently of Msh2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Transcription-targeted DNA deamination by the AID antibody diversification enzyme
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
DNA polymerase kappa deficiency does not affect somatic hypermutation in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Regulation of B-cell fate by antigen-receptor signals
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Chromatin structural analyses of the mouse Igkappa gene locus reveal new hypersensitive sites specifying a transcriptional silencer and enhancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
B cell antigen receptor signaling: roles in cell development and disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Regulation of B-cell signal transduction by adaptor proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Error rate and specificity of human and murine DNA polymerase eta
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Increased transcription levels induce higher mutation rates in a hypermutating cell line
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
The mu switch region tandem repeats are important, but not required, for antibody class switch recombination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Normal isotype switching in B cells lacking the I mu exon splice donor site: evidence for multiple I mu-like germline transcripts.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
E2A activity is induced during B-cell activation to promote immunoglobulin class switch recombination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Hypermutation in Ig V genes from mice deficient in the MLH1 mismatch repair protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Processing of switch transcripts is required for targeting of antibody class switch recombination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Reevaluation of 3'Ekappa function in stage- and lineage-specific rearrangement and somatic hypermutation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
The transcriptional promoter regulates hypermutation of the antibody heavy chain locus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
The immunoglobulin heavy chain locus contains another B-cell-specific 3' enhancer close to the alpha constant region
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Targeting of non-Ig sequences in place of the V segment by somatic hypermutation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
The chicken immunoglobulin λ light chain gene is transcriptionally controlled by a modularly organized enhancer and an octamer-dependent silencer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Repetitive sequences in class-switch recombination regions of immunoglobulin heavy chain genes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
The immunoglobulin kappa locus contains a second, stronger B-cell-specific enhancer which is located downstream of the constant region
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
An enhancer at the 3' end of the mouse immunoglobulin heavy chain locus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
5 July 2018
Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
Multiple layers of B cell memory with different effector functions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
A critical role for REV1 in regulating the induction of C:G transitions and A:T mutations during Ig gene hypermutation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
Progesterone inhibits activation-induced deaminase by binding to the promoter.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
A backup role of DNA polymerase kappa in Ig gene hypermutation only takes place in the complete absence of DNA polymerase eta.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
Active nuclear import and cytoplasmic retention of activation-induced deaminase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
Toll-like receptor 7 cooperates with IL-4 in activated B cells through antigen receptor or CD38 and induces class switch recombination and IgG1 production
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
Aging down-regulates the transcription factor E2A, activation-induced cytidine deaminase, and Ig class switch in human B cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
PI3K is a negative regulator of IgE production
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
Two levels of protection for the B cell genome during somatic hypermutation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
B-cell receptor cross-linking delays activation-induced cytidine deaminase induction and inhibits class-switch recombination to IgE.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
Requirement of non-canonical activity of uracil DNA glycosylase for class switch recombination.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
Regulation of class-switch recombination and plasma cell differentiation by phosphatidylinositol 3-kinase signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
Roles of the Ig kappa light chain intronic and 3' enhancers in Igk somatic hypermutation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
The mutation spectrum of purified AID is similar to the mutability index in Ramos cells and in ung(-/-)msh2(-/-) mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
Comment on "Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch".
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
An evolutionarily conserved target motif for immunoglobulin class-switch recombination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
Separate domains of AID are required for somatic hypermutation and class-switch recombination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
Immunoglobulin class-switch recombination in mice devoid of any S mu tandem repeat.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
Transcription-coupled events associating with immunoglobulin switch region chromatin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
DNA substrate length and surrounding sequence affect the activation-induced deaminase activity at cytidine
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
E-proteins directly regulate expression of activation-induced deaminase in mature B cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
The absence of DNA polymerase kappa does not affect somatic hypermutation of the mouse immunoglobulin heavy chain gene.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
PMS2-deficiency diminishes hypermutation of a lambda1 transgene in young but not older mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
Somatic hypermutation in the heavy chain locus correlates with transcription
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
DNA sequences mediating class switching in alpha-immunoglobulins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
An immunoglobulin deletion mutant with implications for the heavy-chain switch and RNA splicing.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
The mouse IgH 3'-enhancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
A second B cell-specific enhancer 3' of the immunoglobulin heavy-chain locus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954419
retrieved
28 October 2018
Cutting edge: DNA polymerases mu and lambda are dispensable for Ig gene hypermutation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905006-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905006-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Decreased Frequency of Somatic Hypermutation and Impaired Affinity Maturation but Intact Germinal Center Formation in Mice Expressing Antisense RNA to DNA Polymerase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905006-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tristetraprolin, a negative regulator of mRNA stability, is increased in old B cells and is involved in the degradation of E47 mRNA
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905006-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Involvement of the E2A basic helix-loop-helix protein in immunoglobulin heavy chain class switching
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905006-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The immunoglobulin heavy-chain locus hs3b and hs4 3' enhancers are dispensable for VDJ assembly and somatic hypermutation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905006-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA polymerases eta and theta function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905006-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905006-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Histone modifications associated with somatic hypermutation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905006-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Somatic hypermutation of immunoglobulin genes is linked to transcription initiation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905006-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Impact of age on hypermutation of immunoglobulin variable genes in humans
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905006-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cross-Linking Surface Ig Delays CD40 Ligand- and IL-4-Induced B Cell Ig Class Switching and Reveals Evidence for Independent Regulation of B Cell Proliferation and Differentiation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905006-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905006-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The 3' Igkappa enhancer contains RNA polymerase II promoters: implications for endogenous and transgenic kappa gene expression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905006-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Codon bias targets mutation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905006-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Insertion of 2 kb of bacteriophage DNA between an immunoglobulin promoter and leader exon stops somatic hypermutation in a kappa transgene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905006-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0065-2776(10)05006-6
1 reference
stated in
Europe PubMed Central
PMC publication ID
2954419
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20510733%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 February 2020
PMC publication ID
2954419
1 reference
stated in
Europe PubMed Central
PMC publication ID
2954419
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20510733%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 February 2020
PubMed publication ID
20510733
1 reference
stated in
Europe PubMed Central
PMC publication ID
2954419
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20510733%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 February 2020
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