(Q34659146)

3 August 2017

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title

Regulation of B-cell signal transduction by adaptor proteins (English)

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3 August 2017

Tomohiro Kurosaki

1

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3 August 2017

1 May 2002

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Nature Reviews Immunology

3 August 2017

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3 August 2017

2

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3 August 2017

354-363

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3 August 2017

5

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Adapters in lymphocyte signalling

3 August 2017

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Signal transduction from the B cell antigen-receptor

21 January 2018

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Regulation of B cell function by linker proteins

21 January 2018

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Antigen-dependent B-cell development

21 January 2018

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Lipid rafts and B-cell activation

21 January 2018

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The complexity of signaling pathways activated by the BCR.

21 January 2018

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Molecular mechanisms in B cell antigen receptor signaling

21 January 2018

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Initiation and processing of signals from the B cell antigen receptor

21 January 2018

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Antigen receptor signaling: integration of protein tyrosine kinase functions.

21 January 2018

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Lipid rafts and signal transduction

21 January 2018

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Floating the raft hypothesis: lipid rafts play a role in immune cell activation

21 January 2018

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A role for lipid rafts in B cell antigen receptor signaling and antigen targeting

21 January 2018

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Cutting edge: differential sequestration of plasma membrane-associated B cell antigen receptor in mature and immature B cells into glycosphingolipid-enriched domains.

21 January 2018

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Cutting edge: B cell antigen receptor signaling occurs outside lipid rafts in immature B cells

21 January 2018

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Entry of B cell receptor into signaling domains is inhibited in tolerant B cells.

21 January 2018

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Genetic analysis of B cell antigen receptor signaling

21 January 2018

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Functional analysis of Csk in signal transduction through the B-cell antigen receptor.

21 January 2018

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Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases

21 January 2018

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Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation

21 January 2018

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Ubiquitin-dependent degradation of active Src.

21 January 2018

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Ubiquitin-mediated degradation of active Src tyrosine kinase

21 January 2018

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Bruton's tyrosine kinase controls a sustained calcium signal essential for B lineage development and function

21 January 2018

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PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization

21 January 2018

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Direct inhibition of Bruton's tyrosine kinase by IBtk, a Btk-binding protein

21 January 2018

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Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein

21 January 2018

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Cutting edge: essential role of phospholipase C-gamma 2 in B cell development and function

21 January 2018

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Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase.

21 January 2018

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Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.

21 January 2018

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The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling

21 January 2018

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Cholesterol depletion delocalizes phosphatidylinositol bisphosphate and inhibits hormone-stimulated phosphatidylinositol turnover

21 January 2018

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A requirement for lipid rafts in B cell receptor induced Ca(2+) flux

21 January 2018

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Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase

21 January 2018

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SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation

21 January 2018

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bca: an activation-related B-cell gene

21 January 2018

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Involvement of LAT, Gads, and Grb2 in compartmentation of SLP-76 to the plasma membrane

21 January 2018

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Recruitment of SLP-76 to the membrane and glycolipid-enriched membrane microdomains replaces the requirement for linker for activation of T cells in T cell receptor signaling

21 January 2018

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Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alpha

21 January 2018

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Interaction of SLP adaptors with the SH2 domain of Tec family kinases

21 January 2018

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BLNK mediates Syk-dependent Btk activation

21 January 2018

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Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT

21 January 2018

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Requirement for B cell linker protein (BLNK) in B cell development

21 January 2018

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Cd19-dependent activation of Akt kinase in B-lymphocytes

21 January 2018

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Molecular cloning of a novel murine cell-surface glycoprotein homologous to killer cell inhibitory receptors.

21 January 2018

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A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells

21 January 2018

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The paired Ig-like receptor PIR-B is an inhibitory receptor that recruits the protein-tyrosine phosphatase SHP-1.

21 January 2018

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Requirement of SH2-containing protein tyrosine phosphatases SHP-1 and SHP-2 for paired immunoglobulin-like receptor B (PIR-B)-mediated inhibitory signal

21 January 2018

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Paired immunoglobulin-like receptor B (PIR-B) inhibits BCR-induced activation of Syk and Btk by SHP-1

21 January 2018

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Constitutive tyrosine phosphorylation of the inhibitory paired Ig-like receptor PIR-B.

21 January 2018

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Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex

21 January 2018

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The Gab1 protein is a docking site for multiple proteins involved in signaling by the B cell antigen receptor.

21 January 2018

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Essential role for Gab2 in the allergic response

21 January 2018

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Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells.

21 January 2018

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Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation

21 January 2018

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Rac GTPase interacts specifically with phosphatidylinositol 3-kinase

21 January 2018

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Regulatory and signaling properties of the Vav family

21 January 2018

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Transient translocation of the B cell receptor and Src homology 2 domain-containing inositol phosphatase to lipid rafts: evidence toward a role in calcium regulation.

21 January 2018

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The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation

21 January 2018

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A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade.

21 January 2018

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The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways

21 January 2018

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Essential immunoregulatory role for BCAP in B cell development and function

21 January 2018

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Transmembrane Phosphoprotein Cbp Positively Regulates the Activity of the Carboxyl-terminal Src Kinase, Csk

21 January 2018

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T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

21 January 2018

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Xid-like phenotypes: a B cell signalosome takes shape

21 January 2018

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Regulation of B cell fates by BCR signaling components

31 March 2020

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Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex

31 March 2020

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The CD19/CD21 complex functions to prolong B cell antigen receptor signaling from lipid rafts

31 March 2020

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Epstein-Barr virus coopts lipid rafts to block the signaling and antigen transport functions of the BCR.

31 March 2020

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The when and how of Src regulation

31 March 2020

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CD45 modulates phosphorylation of both autophosphorylation and negative regulatory tyrosines of Lyn in B cells

31 March 2020

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Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage

31 March 2020

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A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2.

31 March 2020

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Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors

31 March 2020

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BLNK: a central linker protein in B cell activation

31 March 2020

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BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells

31 March 2020

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LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

31 March 2020

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LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation

31 March 2020

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Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65

31 March 2020

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Fc gammaRIIB1 inhibition of BCR-mediated phosphoinositide hydrolysis and Ca2+ mobilization is integrated by CD19 dephosphorylation

31 March 2020

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Molecular basis of the motheaten phenotype

31 March 2020

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Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection.

31 March 2020

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CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification

31 March 2020

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Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule.

31 March 2020

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Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice.

31 March 2020

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31 March 2020

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SHIP modulates immune receptor responses by regulating membrane association of Btk.

31 March 2020

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Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc(gamma)RIIB.

31 March 2020

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Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling

31 March 2020

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The RasGAP-binding protein p62dok is a mediator of inhibitory FcgammaRIIB signals in B cells

31 March 2020

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Regulation of the TRP Ca2+ channel by INAD in Drosophila photoreceptors

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI801

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3 August 2017

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PubMed ID

12033741