(Q34551108)

3 August 2017

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title

Targeting of somatic hypermutation (English)

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3 August 2017

Valerie H Odegard

1

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3 August 2017

David G Schatz

series ordinal

2

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3 August 2017

publication date

1 August 2006

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Nature Reviews Immunology

3 August 2017

published in

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3 August 2017

volume

6

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3 August 2017

issue

8

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3 August 2017

page(s)

573-583

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Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease

3 August 2017

cites work

1 reference

Cutting edge: DGYW/WRCH is a better predictor of mutability at G:C bases in Ig hypermutation than the widely accepted RGYW/WRCY motif and probably reflects a two-step activation-induced cytidine deaminase-triggered process

21 January 2018

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Somatic hypermutation in the heavy chain locus correlates with transcription

21 January 2018

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Increased transcription levels induce higher mutation rates in a hypermutating cell line

21 January 2018

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The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially

21 January 2018

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Targeting of the activation-induced cytosine deaminase is strongly influenced by the sequence and structure of the targeted DNA.

21 January 2018

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The very 5' end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions

21 January 2018

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Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

21 January 2018

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Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

21 January 2018

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Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion

21 January 2018

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AID is essential for immunoglobulin V gene conversion in a cultured B cell line

21 January 2018

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Constitutive expression of AID leads to tumorigenesis

21 January 2018

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AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

21 January 2018

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AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts

21 January 2018

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Separate domains of AID are required for somatic hypermutation and class-switch recombination

21 January 2018

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AID mutant analyses indicate requirement for class-switch-specific cofactors

21 January 2018

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C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion.

21 January 2018

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Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1

21 January 2018

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Activation-induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaks

21 January 2018

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Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase

21 January 2018

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Replication protein A interacts with AID to promote deamination of somatic hypermutation targets

21 January 2018

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PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells

21 January 2018

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The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation

21 January 2018

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Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

21 January 2018

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Transcription-targeted DNA deamination by the AID antibody diversification enzyme

21 January 2018

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Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

21 January 2018

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Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

21 January 2018

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AID mediates hypermutation by deaminating single stranded DNA.

21 January 2018

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DNA substrate length and surrounding sequence affect the activation-induced deaminase activity at cytidine

21 January 2018

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Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

21 January 2018

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Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations

21 January 2018

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Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled

21 January 2018

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Immunity through DNA deamination

21 January 2018

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MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes

21 January 2018

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Uracil in DNA--occurrence, consequences and repair

21 January 2018

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What role for AID: mutator, or assembler of the immunoglobulin mutasome?

21 January 2018

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MRE11/RAD50 cleaves DNA in the AID/UNG-dependent pathway of immunoglobulin gene diversification

21 January 2018

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AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization

21 January 2018

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Nuclear and cytoplasmic AID in extrafollicular and germinal center B cells

21 January 2018

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AID in somatic hypermutation and class switch recombination

21 January 2018

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Class-switch recombination: interplay of transcription, DNA deamination and DNA repair

21 January 2018

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Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes

21 January 2018

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The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process

21 January 2018

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DNA double-strand breaks: prior to but not sufficient in targeting hypermutation

21 January 2018

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AID-dependent generation of resected double-strand DNA breaks and recruitment of Rad52/Rad51 in somatic hypermutation

21 January 2018

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Histone H2A variants H2AX and H2AZ

21 January 2018

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H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation

21 January 2018

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Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin

21 January 2018

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Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation

21 January 2018

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Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

21 January 2018

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Inducible DNA breaks in Ig S regions are dependent on AID and UNG

21 January 2018

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BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci

21 January 2018

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Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes

21 January 2018

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Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction

21 January 2018

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Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

21 January 2018

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Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a).

21 January 2018

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Negative regulation of activation-induced cytidine deaminase in B cells

21 January 2018

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Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.

21 January 2018

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AID is required for c-myc/IgH chromosome translocations in vivo

21 January 2018

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H2AX prevents DNA breaks from progressing to chromosome breaks and translocations

21 January 2018

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The TATA binding protein, c-Myc and survivin genes are not somatically hypermutated, while Ig and BCL6 genes are hypermutated in human memory B cells.

21 January 2018

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Factors and forces controlling V(D)J recombination

21 January 2018

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Somatic hypermutation of an immunoglobulin transgene in kappa transgenic mice.

21 January 2018

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Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: implications for the location of cis-acting elements required for somatic mutation

21 January 2018

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The transcriptional promoter regulates hypermutation of the antibody heavy chain locus

21 January 2018

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A lambda 1 transgene under the control of a heavy chain promoter and enhancer does not undergo somatic hypermutation

21 January 2018

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Somatic hypermutation of an immunoglobulin mu heavy chain transgene

21 January 2018

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Targeting of non-Ig sequences in place of the V segment by somatic hypermutation.

21 January 2018

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Fine Mapping of an Immunoglobulin Gene Activator

21 January 2018

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Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers.

21 January 2018

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Reevaluation of 3'Ekappa function in stage- and lineage-specific rearrangement and somatic hypermutation

21 January 2018

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Roles of the Ig kappa light chain intronic and 3' enhancers in Igk somatic hypermutation

21 January 2018

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Complex regulation of somatic hypermutation by cis-acting sequences in the endogenous IgH gene in hybridoma cells

21 January 2018

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Elucidation of IgH intronic enhancer functions via germ-line deletion

21 January 2018

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Chromatin structural analyses of the mouse Igkappa gene locus reveal new hypersensitive sites specifying a transcriptional silencer and enhancer

21 January 2018

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Regulation of activation and recombination of the murine Igkappa locus

21 January 2018

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Immunoglobulin gene transcription

21 January 2018

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The role of E-proteins in B- and T-lymphocyte development

21 January 2018

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A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression

21 January 2018

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The chicken Ig light chain 3'-enhancer is essential for gene expression and regulates gene conversion via the transcription factor E2A.

21 January 2018

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Histone acetylation and deacetylation in yeast

21 January 2018

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Transcription-coupled events associating with immunoglobulin switch region chromatin

21 January 2018

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Differential regulation of histone acetylation and generation of mutations in switch regions is associated with Ig class switching

21 January 2018

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Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome.

21 January 2018

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Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase

21 January 2018

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Sterile 20 kinase phosphorylates histone H2B at serine 10 during hydrogen peroxide-induced apoptosis in S. cerevisiae

21 January 2018

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Phosphorylation of histone H2B at DNA double-strand breaks.

21 January 2018

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Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites

21 January 2018

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A role for Saccharomyces cerevisiae histone H2A in DNA repair.

21 January 2018

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Genome-wide somatic hypermutation

21 January 2018

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AID mutates a non-immunoglobulin transgene independent of chromosomal position.

21 January 2018

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Transcription-dependent somatic hypermutation occurs at similar levels on functional and nonfunctional rearranged IgH alleles.

21 January 2018

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Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development

21 January 2018

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Interchromosomal associations between alternatively expressed loci

21 January 2018

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DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation

21 January 2018

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Effects of Sequence and Structure on the Hypermutability of Immunoglobulin Genes

21 January 2018

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Hypermutation: give us a break

21 January 2018

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Progress in understanding the mechanism and consequences of somatic hypermutation

21 January 2018

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Somatic hypermutation of immunoglobulin genes is linked to transcription initiation

31 March 2020

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Histone modifications associated with somatic hypermutation

31 March 2020

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The Bcl6 locus is not mutated in mouse B-cell lineage lymphomas

31 March 2020

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Monitoring and interpreting the intrinsic features of somatic hypermutation

31 March 2020

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Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes.

31 March 2020

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Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

31 March 2020

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Multiple sequences from downstream of the J kappa cluster can combine to recruit somatic hypermutation to a heterologous, upstream mutation domain

31 March 2020

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Somatic hypermutation of immunoglobulin kappa transgenes: association of mutability with demethylation

31 March 2020

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The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription

31 March 2020

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The Ig(kappa) enhancer influences the ratio of Ig(kappa) versus Ig(lambda) B lymphocytes

31 March 2020

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Evaluation of the role of the 3'alpha heavy chain enhancer [3'alpha E(hs1,2)] in Vh gene somatic hypermutation

31 March 2020

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Transcriptional regulation during B cell development

31 March 2020

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Gcn4 activator targets Gcn5 histone acetyltransferase to specific promoters independently of transcription

31 March 2020

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Analysis of hypermutation in immunoglobulin heavy chain passenger transgenes

31 March 2020

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A pivotal role for DNase I-sensitive regions 3b and/or 4 in the induction of somatic hypermutation of IgH genes

31 March 2020

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The immunoglobulin heavy-chain locus hs3b and hs4 3' enhancers are dispensable for VDJ assembly and somatic hypermutation

31 March 2020

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Lessons in transcriptional regulation learned from studies on immunoglobulin genes.

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI1896

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3 August 2017

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